4-[(1Z)-1-(4-methoxyphenyl)penta-1,4-dien-3-yl]phenol

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 4-[(1Z)-1-(4-methoxyphenyl)penta-1,4-dien-3-yl]phenol
• 化学式: C₁₈H₁₈O₂
• 分子量: 266.3
• InChiKey: MTYGOTBQCBXZQD-DAXSKMNVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Nyasol and Analogs Thereof for the Treatment of Estrogen Receptor Beta-Mediated Diseases
  申请人：Cohen Isaac

  公开号：US20090312274A1

  公开（公告）日：2009-12-17

  Estrogenic compositions comprising nyasol and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.

  提供了包含尼阿索尔及其类似物的雌激素组合物。还提供了使用这些提取物以实现雌激素效应的方法，特别是在人类中，例如女性。在某些实施例中，这些方法包括治疗更年期症状。在某些实施例中，这些方法包括治疗雌激素受体阳性癌症，如对雌激素敏感的乳腺癌。在某些实施例中，这些方法包括治疗或预防骨质疏松症。
• NYASOL AND ANALOGS THEREOF FOR THE TREATMENT OF ESTROGEN RECEPTOR BETA-MEDIATED DISEASES
  申请人：Cohen Isaac

  公开号：US20120277169A1

  公开（公告）日：2012-11-01

  Estrogenic compositions comprising nyasol and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.

  提供了包含nyasol及其类似物的雌激素组合物。还提供了使用该提取物以达到雌激素效应的方法，特别是在人类中，例如女性。在某些实施例中，该方法包括治疗更年期症状。在某些实施例中，该方法包括治疗雌激素受体阳性癌症，例如雌激素敏感性乳腺癌。在某些实施例中，该方法包括治疗或预防骨质疏松症。
• [EN] NYASOL AND ANALOGS THEREOF FOR THE TREATMENT OF ESTROGEN RECEPTOR BETA-MEDIATED DISEASES<br/>[FR] NYASOL ET SES ANALOGUES POUR LE TRAITEMENT DE MALADIES À MÉDIATION PAR LE RÉCEPTEUR BÊTA DES OESTROGÈNES
  申请人：BIONOVO INC

  公开号：WO2010053600A2

  公开（公告）日：2010-05-14

  Estrogenic compositions comprising nyasol and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.