Macolidine | 66288-77-5

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: Macolidine
• 英文别名: (1S,14R)-20,25-dimethoxy-15,30-dimethyl-8,23-dioxa-15,30-diazaheptacyclo[22.6.2.29,12.13,7.114,18.027,31.022,33]hexatriaconta-3(36),4,6,9(35),10,12(34),18,20,22(33),24,26,31-dodecaene-6,21-diol
• CAS: 66288-77-5
• 化学式: C₃₆H₃₈N₂O₆
• 分子量: 594.7
• InChiKey: LFFQVHXIFJLJSP-WUFINQPMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  44
• 可旋转键数：
  2
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• NF-kB activity inhibitor
  申请人：Kaken Shoyaku Co., Ltd.

  公开号：EP0931544A2

  公开（公告）日：1999-07-28

  This invention relates to an NF-κB activity inhibitor which contains alkaloids originated from a plant belonging to the genus Stephania of the family Menspermaceae, derivatives thereof and salts thereof, as the active components, to an agent for use in the treatment and prevention of diseases upon which the NF-κB activity inhibiting action is effective and to an inhibitor of the expression of related genes. Since said active components exert an action to inhibit transcription of DNA having an NF-κB recognition sequence by inhibiting the activity of NF-κB, the drug of the present invention can inhibit expression of genes of certain substances such as cytokines, inflammatory cytokine receptor antagonists, MHC class I, MHC class II, β2 microglobulin, immunoglobulin light chain, serum amyloid A, angiotensinogen, complement B, complement C4, C-myc gene, HIV, SV40, CMV, adenovirus and the like, so that the inventive drug is useful in treating and/or preventing various diseases in which these substances are taking roles.

  本发明涉及一种NF-κB活性抑制剂，其活性成分含有源自一种属于孟婆子科斯蒂芬尼亚属植物的生物碱、其衍生物及其盐类，涉及一种用于治疗和预防NF-κB活性抑制作用有效的疾病的药物，还涉及一种相关基因表达抑制剂。MHCⅠ类、MHCⅡ类、β2微球蛋白、免疫球蛋白轻链、血清淀粉样蛋白A、血管紧张素原、补体B、补体C4、C-myc基因、HIV、SV40、CMV、腺病毒等，因此本发明药物可用于治疗和/或预防这些物质起作用的各种疾病。
• Association between neopterin concentration and neurovascular charges in type-2 diabetes patients—effect of an Ayurvedic formulation mainly containing Berberis aristata
  申请人：Gill Harinder Singh

  公开号：US10149879B2

  公开（公告）日：2018-12-11

  Provided herein are plant based formulations for the prevention and management of diabetic vascular complication The formulation include hydro-alcoholic extract of Berberis Aristata, Trigonella foenum-graceum and Salacia parviflora in an effective dose. Also provided herein are methods of using such formulations.

  本文提供了用于预防和治疗糖尿病血管并发症的植物制剂，该制剂包括有效剂量的小檗、毛蕊花和侧柏的水醇提取物。本文还提供了使用此类制剂的方法。
• Synergistic antipyretic formulation
  申请人：Pushpangadan Palpu

  公开号：US20060141069A1

  公开（公告）日：2006-06-29

  The present invention relates to a synergistic antipyretic formulation comprising extracts of plants Berberis aristata, Tinospora cordifolia, Alstonia scholaris, Andrographis paniculata and Hedychium spicatum , optionally along with pharmaceutically acceptable additives; its use in treating fever, and lastly, a process for the preparation said synergistic antipyretic formulation.

  本发明涉及一种协同解热配方，包括以下植物的提取物 小檗、虎杖、穿心莲、穿心莲 和 植物提取物 最后是制备所述协同解热配方的工艺。
• Modulating plant alkaloids
  申请人：Apuya Nestor

  公开号：US20060195934A1

  公开（公告）日：2006-08-31

  Materials and methods are provided for identifying regulatory region-regulatory protein associations and modulating expression of a sequence of interest. For example, a plant cell is provided containing a regulatory protein that can modulate expression of one or more genes involved in alkaloid biosynthesis in plants, which, in turn, can modulate the amount and/or rate of biosynthesis of one or more alkaloid compounds.

  本文提供了用于识别调控区-调控蛋白关联和调节相关序列表达的材料和方法。例如，提供了一种含有调控蛋白的植物细胞，该调控蛋白可调节参与植物生物碱生物合成的一个或多个基因的表达，进而调节一个或多个生物碱化合物的生物合成量和/或速率。
• Secondary metabolite production via manipulation of genome methylation
  申请人：Pennell I. Roger

  公开号：US20060236421A1

  公开（公告）日：2006-10-19

  Methods for modulating the rate of production and accumulation of secondary metabolites, e.g., alkaloid, terpenoid or phenylpropanoid compounds, are disclosed. Also disclosed are compositions useful in such methods, e.g., a plant containing a recombinant nucleic acid that is effective for reducing the level of general DNA methylation.

  本发明公开了调节次生代谢物（如生物碱、萜类或苯丙类化合物）产生和积累速度的方法。还公开了用于此类方法的组合物，例如含有重组核酸的植物，该核酸可有效降低一般 DNA 甲基化水平。