hydroxyethyl methyl fumarate | 16062-94-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: hydroxyethyl methyl fumarate
• 英文别名: 2-hydroxyethyl methyl fumarate；4-O-(2-hydroxyethyl) 1-O-methyl (E)-but-2-enedioate
• CAS: 16062-94-5
• 化学式: C₇H₁₀O₅
• 分子量: 174.153
• InChiKey: GCTWZXLKCMVCKS-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  hydroxyethyl methyl fumarate 在 sodium dihydrogenphosphate 盐酸 、 4 A molecular sieve 作用下， 以 四氢呋喃 、 水 、 苯 为溶剂， 反应 18.0h， 生成 (1S,2S,4aR,8aR)-4-Oxo-decahydro-naphthalene-1,2-dicarboxylic acid 2-(2-hydroxy-ethyl) ester 1-methyl ester
  参考文献：
  名称：

  2型分子内Diels-Alder环加成反应中的一次性系链。在立体化学控制中的应用

  摘要：

  2型分子内Diels-Alder环加成反应中二烯和亲二烯体的临时结合提供了控制环加成反应的区域化学和立体化学的一般策略。

  DOI：

  10.1016/s0040-4039(00)97985-1
• 作为产物：
  描述：

  环氧乙烷 、 monomethyl fumarate 、 叔丁胺氢溴酸盐 在 水 、 氯仿 、 magnesium sulfate 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以to give the product, 2-hydroxyethyl methyl fumarate (but-2-enedioic acid 2-hydroxyethyl ester methyl ester)的产率得到hydroxyethyl methyl fumarate
  参考文献：
  名称：

  PRODRUGS OF MONOMETHYL FUMARATE (MMF)

  摘要：

  本发明涉及新型化合物作为药物的用途。具体而言，本发明涉及新型丙烯酸单甲酯（MMF）的前药，适用于药物，优选用于治疗和/或预防全身性疾病，自身免疫性疾病，炎症性疾病，例如多发性硬化和牛皮癣。

  公开号：

  US20150299103A1

文献信息

• A paper coating composition and its production
  申请人：Sumitomo Naugatuck Co., Ltd.

  公开号：EP0013031A1

  公开（公告）日：1980-07-09

  A coating composition for paper comprising a mineral pigment and a polymer latex prepared by emulsion polymerization of an aliphatic conjugated diene monomer, an ethylenically unsaturated carboxylic acid monomer and a monoolefinic monomer in a weight proportion of 24.5 - 50 : 0.5 -5 : 45 - 75 in the presence of a chain transfer agent, characterized in that the chain transfer agent is carbon tetrachloride and an alkylmercaptan in combination.

  一种用于纸张的涂料组合物，包括矿物颜料和聚合物胶乳，聚合物胶乳是由脂肪族共轭二烯单体、乙烯基不饱和羧酸单体和单烯烃单体在有链转移剂存在的情况下，以 24.5 - 50 : 0.5 -5 : 45 - 75 的重量比例进行乳液聚合制备而成，其特征在于链转移剂是四氯化碳和烷基硫醇的混合物。
• Azlactone-functional silicon containing compounds and derivatives thereof
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0419283A2

  公开（公告）日：1991-03-27

  Azlactone functional silicon containing compounds are prepared from alkenyl azlactones and SiH containing compounds in a hydrosilation reaction. The resulting compounds can be reacted with nucleophilic compounds to group containing silicon compounds. When the amidoacyl group containing silicon compounds contain ethylenic unsaturated they can be polymerized to provide polymeric networks useful as pressure sensitive adhesives release compositions, or elastomeric materials.

  含硅的氮内酯官能团化合物是由烯基氮内酯和含 SiH 的化合物通过加氢反应制备而成。生成的化合物可与亲核化合物反应生成含硅化合物基团。当酰胺酰基含硅化合物含有乙烯不饱和时，它们可以聚合成聚合物网络，用作压敏粘合剂释放组合物或弹性材料。
• Process for preparing copolymer latex and use of copolymer latex
  申请人：Sumitomo Dow Limited

  公开号：EP0496925A1

  公开（公告）日：1992-08-05

  A copolymer latex which is useful in an adhesive composition, a paper coating composition, an adhesive composition for carpet lining and an adhesive composition for a rock fiber substrate is prepared by emulsion copolymerizing an aliphatic conjugated diene monomer and at least one other monomer copolymerizable therewith in the presence of a chain transfer agent and at least one compound having no copolymerizing reactivity selected from the group consisting of hydrocarbons having 5 to 12 carbon atoms, halogenated aromatic hydrocarbons, five or six membered ring heterocyclic compounds, aliphatic ethers and aliphatic esters in an amount of 1 to 100 parts by weight per 100 parts by weight of a total amounts of the aliphatic conjugated diene monomer and the other monomer.

  一种可用于粘合剂组合物、纸张涂层组合物、地毯衬里粘合剂组合物和岩石纤维基材粘合剂组合物的共聚乳胶，是在链转移剂和至少一种不具有共聚反应活性的化合物的存在下，通过乳液共聚脂肪族共轭二烯单体和至少一种可与之共聚的其他单体而制备的，这些化合物选自由具有 5 至 12 个碳原子的碳氢化合物组成的组、卤代芳香烃、五或六元环杂环化合物、脂肪族醚和脂肪族酯，其用量为脂肪族共轭二烯单体和另一种单体的总量每 100 重量份中含 1 至 100 重量份。
• Flame retardant polymer emulsion
  申请人：Zakikhani, Mohsen

  公开号：EP1739109A1

  公开（公告）日：2007-01-03

  The invention provides a flame retardant material which comprises a flame retardant polymer emulsion obtained by the polymerisation of at least one unsaturated monomer comprising at least one phosphorus atom. Preferably, said monomer is copolymerised with at least one co-monomer. The flame retardant material may be used for the preparation of flame retardant formulations which find particular application in the preparation of intumescent coatings, back coating layers for fabrics, flame retardant finishes for wood, textile fibres and polymer castings. The flame retardant materials of the invention show significant advantages over the materials of the prior art in terms of ease and cost of preparation and with regard to health, safety and environmental considerations.

  本发明提供了一种阻燃材料，它由至少一种含有至少一个磷原子的不饱和单体聚合而成的阻燃聚合物乳液组成。上述单体最好与至少一种共聚单体共聚。这种阻燃材料可用于制备阻燃配方，尤其适用于制备膨胀涂料、织物背面涂层、木材阻燃整理剂、纺织纤维和聚合物铸件。与现有技术的材料相比，本发明的阻燃材料在制备的简便性和成本方面，以及在健康、安全和环保方面都具有显著优势。
• BINDER COMPOSITION FOR LITHIUM ION SECONDARY CELL ELECTRODE, SLURRY COMPOSITION FOR LITHIUM ION SECONDARY CELL ELECTRODE, LITHIUM ION SECONDARY CELL ELECTRODE, AND LITHIUM ION SECONDARY CELL
  申请人：Zeon Corporation

  公开号：EP3154113A1

  公开（公告）日：2017-04-12

  Provided is a binder composition for lithium ion secondary battery electrode-use that reduces internal resistance of a lithium ion secondary battery while also providing the lithium ion secondary battery with excellent life characteristics. The binder composition contains a copolymer X and a solvent. The copolymer X is obtained from a monomer composition X that contains at least 20.0 mass% and no greater than 75.0 mass% of an ethylenically unsaturated carboxylic acid compound (A) composed of either or both of an ethylenically unsaturated carboxylic acid and an ethylenically unsaturated carboxylic acid salt, and at least 20.0 mass% and no greater than 75.0 mass% of a copolymerizable compound (B) that has an ethylenically unsaturated bond and a solubility of at least 7 g in 100 g of water at 20°C. The copolymer X has a degree of swelling in electrolysis solution of less than 120 mass%.

  本发明提供了一种用于锂离子二次电池电极的粘结剂组合物，它能降低锂离子二次电池的内阻，同时还能使锂离子二次电池具有出色的寿命特性。该粘结剂组合物包含共聚物 X 和溶剂。共聚物 X 由单体组合物 X 获得，该单体组合物含有至少 20.0 质量％但不大于 75.0 质量％的乙烯基不饱和羧酸化合物 (A)，该化合物由乙烯基不饱和羧酸和乙烯基不饱和羧酸盐中的一种或两种组成，以及至少 20.0质量％但不大于75.0质量％的可共聚化合物(B)，该化合物具有乙烯基不饱和键，且在20℃时在100克水中的溶解度至少为7克。共聚物 X 在电解溶液中的溶胀度小于 120 质量％。