(E)-4-quinolin-2-ylbut-3-en-2-one;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-4-quinolin-2-ylbut-3-en-2-one;hydrochloride
• 化学式: C13H12ClNO
• 分子量: 233.69
• InChiKey: FJQZIZCRUCJZIA-WVLIHFOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.74
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  31.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• THREE-DIMENSIONAL CAVITIES OF DENDRITIC CELL IMMUNORECEPTOR (DCIR), COMPOUNDS BINDING THERETO AND THERAPEUTIC APPLICATIONS RELATED TO INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1)
  申请人：Universite Laval

  公开号：US20150157705A1

  公开（公告）日：2015-06-11

  The invention is concerned with compounds, pharmaceutical compositions, screening methods, and therapeutic methods for preventing or reducing a human immunodeficiency virus type-1 (HIV-1) infection and/or propagation associated with dendritic cell immunoreceptor (DCIR). Described herein are compounds which bind on at least one three-dimensional cavity of the DCIR, the cavity(ies) being involved in the interaction between HIV-1 and DCIR. Also described are screening methods for identifying active inhibitors and method of using such inhibitors for the prevention or treatment of virus infections, and more particularly for reducing human immunodeficiency virus type-1 (HIV-1) binding, entry and/or replication in human cells.
• US9731001B2
  申请人：——

  公开号：US9731001B2

  公开（公告）日：2017-08-15