3-(4-methoxy-10-nitro-8,14,15-triazatetracyclo[7.6.1.02,7.013,16]hexadeca-1,3,5,7,9,11,13(16)-heptaen-14-yl)-N,N-dimethylpropan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(4-methoxy-10-nitro-8,14,15-triazatetracyclo[7.6.1.02,7.013,16]hexadeca-1,3,5,7,9,11,13(16)-heptaen-14-yl)-N,N-dimethylpropan-1-amine
• 化学式: C19H21N5O3
• 分子量: 367.4
• InChiKey: HVRZAFDJOWIDMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  86.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Use of topoisomerase inhibitors and heat shock protein 90 inhibitors for use in chemotherapy
  申请人：Jenkins John

  公开号：US20050245466A1

  公开（公告）日：2005-11-03

  The present invention relates to the use of a first agent that attenuates topoisomerase II (Topo II) activity and a second agent that inhibits Heat Shock Protein 90 (HSP90) for use in chemotherapy. The agents are particularly useful in the treatment of cancer and destruction of micro-organisms. The invention also relates to screening methods, diagnostic methods and methods for evaluating or monitoring chemotherapy regimens.

  本发明涉及第一种减弱拓扑异构酶 II（Topo II）活性的药剂和第二种抑制热休克蛋白 90（HSP90）的药剂在化疗中的应用。这些制剂特别适用于治疗癌症和消灭微生物。本发明还涉及筛选方法、诊断方法和评估或监测化疗方案的方法。
• USE OF TOPOISOMERASE INHIBITORS AND HEAT SHOCK PROTEIN 90 INHIBITORS FOR USE IN CHEMOTHERAPY
  申请人：THE UNIVERSITY OF LIVERPOOL

  公开号：EP1490051A1

  公开（公告）日：2004-12-29
• [EN] USE OF TOPOISOMERASE INHIBITORS AND HEAT SHOCK PROTEIN 90 INHIBITORS FOR USE IN CHEMOTHERAPY<br/>[FR] UTILISATION D'INHIBITEURS DE TOPOISOMERASE ET D'INHIBITEURS DE PROTEINE DU STRESS 90, EN VUE DE LEUR EMPLOI EN CHIMIOTHERAPIE
  申请人：UNIV LIVERPOOL

  公开号：WO2003082266A1

  公开（公告）日：2003-10-09

  The present invention relates to the use of a first agent that attenuates Topoisomerase II (Topo II) activity and a second agent that inhibits Heat Shock Protein 90 (HSP90) for use in chemotherapy. The agents are particularly useful in the treatment of cancer and destruction of micro-organisms. The invention also relates to screening methods, diagnostic methods and methods for evaluating or monitoring chemotherapy regimens.