6-[2-[(1E,3E)-4-anilinobuta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]hexanoic acid;bromide | 1164240-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-[2-[(1E,3E)-4-anilinobuta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]hexanoic acid;bromide
• CAS: 1164240-62-3；1235585-98-4
• 化学式: Br*C₂₆H₃₁N₂O₂
• 分子量: 483.448
• InChiKey: GESNUHFWTABBBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.89
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-[2-[(1E,3E)-4-anilinobuta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]hexanoic acid;bromide 、 1,2,3,3-四甲基-3H-吲哚鎓碘化物 在 吡啶 、 溶剂黄146 作用下， 反应 2.0h， 以361 mg的产率得到CY5羧基
  参考文献：
  名称：

  Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia

  摘要：

  Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

  DOI：

  10.1021/ja105937q
• 作为产物：
  描述：

  6-(2,3,3-三甲基吲哚-1-鎓-1-基)己酸溴化物 、 丙二醛双苯亚胺单盐酸盐 在 乙酸酐 、 溶剂黄146 作用下， 反应 4.0h， 生成 6-[2-[(1E,3E)-4-anilinobuta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]hexanoic acid;bromide
  参考文献：
  名称：

  Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia

  摘要：

  Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

  DOI：

  10.1021/ja105937q

文献信息

• Luminescent compounds
  申请人：Terpetschnig Ewald A.

  公开号：US08552027B2

  公开（公告）日：2013-10-08

  Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkage are selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye, or a styryl dye.

  基于聚甲烯染料的染料和光致发光化合物，其中至少含有一个烷基膦酸酯或取代烷基膦酸酯基团，包括合成前体、合成方法及其应用。某些实施例包括选择杂环环系统和聚甲烯链结构，以使得所得的聚甲烯染料为青菁染料、美洛青菁染料或偶氮染料。
• LUMINESCENT COMPOUNDS
  申请人：Terpetschnig Ewald A.

  公开号：US20120035346A1

  公开（公告）日：2012-02-09

  Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkage are selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye, or a styryl dye.

  基于聚甲烯染料的染料和光致发光化合物，其中至少含有一个烷基膦酸酯或取代烷基膦酸酯基团，包括合成前体、合成方法及其应用。某些实施例包括选择杂环环系统和聚甲烯链结构，以使得所得的聚甲烯染料为青菁染料、美洛青菁染料或偶氮染料。
• Synthesis and Photostability of Unimolecular Submersible Nanomachines: Toward Single-Molecule Tracking in Solution
  作者：Víctor García-López、Jonathan Jeffet、Shunsuke Kuwahara、Angel A. Martí、Yuval Ebenstein、James M. Tour

  DOI：10.1021/acs.orglett.6b00506

  日期：2016.5.20

  The synthesis and photophysical properties of a series of photostable unimolecular submersible nanomachines (USNs) are reported as a first step toward the analysis of their trajectories in solution. The USNs have a light-driven rotatory motor for propulsion in solution and photostable cy5-COT fluorophores for their tracking. These cy5-COT fluorophores are found to provide an almost 2-fold increase

  报道了一系列光稳定单分子潜水纳米机器 (USN) 的合成和光物理特性，这是分析它们在溶液中的轨迹的第一步。USN 具有用于在溶液中推进的光驱动旋转电机和用于跟踪的光稳定 cy5-COT 荧光团。与以前的 USN 版本相比，这些 cy5-COT 荧光团的光稳定性提高了近 2 倍，并且不影响电机的旋转。
• US8552027B2
  申请人：——

  公开号：US8552027B2

  公开（公告）日：2013-10-08
• US9110069B2
  申请人：——

  公开号：US9110069B2

  公开（公告）日：2015-08-18