4-bromo-1-methoxy-2-(γ-chlorobutanoyl)benzene | 69639-78-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-bromo-1-methoxy-2-(γ-chlorobutanoyl)benzene
• 英文别名: 5-Brom-2-methoxyphenyl-3-chlorpropylketon；1-(5-Bromo-2-methoxyphenyl)-4-chloro-1-butanone；1-(5-bromo-2-methoxyphenyl)-4-chlorobutan-1-one
• CAS: 69639-78-7
• 化学式: C₁₁H₁₂BrClO₂
• 分子量: 291.572
• InChiKey: LTRIZOKXRWVWNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-bromo-1-methoxy-2-(γ-chlorobutanoyl)benzene 以16%的产率得到
  参考文献：
  名称：

  APSIMON J. W.; DURHAM D. G.; REES A. H., J. CHEM. SOC. PERKIN. TRANS., 1978, PART 1, NO 12, 1588-1594

  摘要：

  DOI：
• 作为产物：
  描述：

  4-溴苯甲醚 、 4-氯丁酰氯 以 aluminium chloride 为溶剂， 以55%的产率得到4-bromo-1-methoxy-2-(γ-chlorobutanoyl)benzene
  参考文献：
  名称：

  Novel compounds

  摘要：

  提供了一种化合物，其化学式为（I）1，其中R1、R2、R3、X和Z的定义如规范中所述，以及其光学异构体、消旋体和互变异构体，以及其药用可接受的盐；以及它们的制备过程、含有它们的组合物和它们在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂。

  公开号：

  US20020137736A1

文献信息

• Amidine derivatives which are inhibitors of nitric oxide synthase
  申请人：——

  公开号：US20020137750A1

  公开（公告）日：2002-09-26

  There are provided novel compounds of formula (I) 1 wherein R 1 , R 2 , X, Y and Z are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; tocether with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.

  提供了式(I)1的新化合物，其中R1、R2、X、Y和Z如规范中定义，并其光学异构体、消旋体和互变异构体以及其药学上可接受的盐；以及它们的制备过程、含有它们的组合物以及它们在治疗中的应用。这些化合物是一氧化氮合酶的抑制剂。
• Novel compounds
  申请人：——

  公开号：US20020137736A1

  公开（公告）日：2002-09-26

  There are provided novel compounds of formula (I) 1 wherein R 1 , R 2 , R 3 , X and Z are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.

  提供了一种化合物，其化学式为（I）1，其中R1、R2、R3、X和Z的定义如规范中所述，以及其光学异构体、消旋体和互变异构体，以及其药用可接受的盐；以及它们的制备过程、含有它们的组合物和它们在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂。
• Synthesis of derivatives of dihydro-1,2-oxazine and tetrahydro-1,2-diazine from (4-chlorobutanoyl)-alkoxybenzenes
  作者：N. N. Yusubov、Shaban Radvan、V. M. Ismailov、N. F. Dzhanibekov

  DOI：10.1007/bf00864209

  日期：1992.7

  The reaction of (4-chlorobutanoyl)alkoxybenzenes with hydroxylamine and 2,4-dinitrophenylhydrazine gave dihydro-1,2-oxazines and tetrahydro-1,2-diazines, respectively.
• [EN] AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] DERIVES D'AMIDINE INHIBITEURS DE L'OXYDE NITRIQUE SYNTHASE
  申请人：ASTRAZENECA AB

  公开号：WO2001046170A1

  公开（公告）日：2001-06-28

  There are provided novel compounds of formula (I) wherein R?1, R2, R3¿, X and Z are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.
• [EN] AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] DERIVES D'AMIDINE INHIBITEURS D'OXYDE NITRIQUE SYNTHASE
  申请人：ASTRAZENECA AB

  公开号：WO2001046171A1

  公开（公告）日：2001-06-28

  There are provided novel compounds of formula (I) wherein R1, R2, X, Y and Z are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.