(2Z)-2-benzylidenebutanamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2Z)-2-benzylidenebutanamide
• 化学式: C₁₁H₁₃NO
• 分子量: 175.23
• InChiKey: XQJLGXMAEVIFDR-NTMALXAHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS<br/>[FR] DÉRIVÉS DE QUINOLONE À UTILISER EN TANT QU'INHIBITEURS DE FACTEUR DE CROISSANCE DES FIBROBLASTES
  申请人：PRINCIPIA BIOPHARMA INC

  公开号：WO2014182829A1

  公开（公告）日：2014-11-13

  Compounds of formula (Ι') that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  公式（Ι'）的化合物是成纤维细胞生长因子抑制剂（FGFR），因此可用于治疗可以通过抑制FGFR治疗的疾病。还披露了包含此类化合物的药物组合物以及制备此类化合物的过程。
• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• [EN] CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS<br/>[FR] DERIVES DE LA CINNAMIDE MODULATEURS DU CANAL POTASSIQUE KCNQ
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002096858A1

  公开（公告）日：2002-12-05

  There is provided novel cinnamide derivatives of Formula I wherein R is C1-4 alkyl or trifluoromethyl, R1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chromanyl, indanyl, biphenylyl, phenyl and substituted phenyl which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.

  提供了一种新的苯甲酰胺衍生物，其化学式为I，其中R为C1-4烷基或三氟甲基，R1选自吡啶基，喹啉基，噻吩基，呋喃基，1,4-苯并二氧杂环基，1,3-苯并二氧杂环基，色甘醇基，茚基，联苯基，苯基和取代苯基，这些化合物是KCNQ钾通道的开放剂，可用于治疗对KCNQ钾通道的开放反应的疾病。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• Transdermal drug delivery device including an occlusive backing
  申请人：Noven Pharmaceuticals, Inc.

  公开号：US10231938B2

  公开（公告）日：2019-03-19

  A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer.

  一种透皮给药系统，用于局部应用一种或多种活性剂，这些活性剂包含在一个或多个聚合物和/或粘合剂载体层中，靠近一个不含药物的聚合物背层，该背层可通过调节聚合物背层的湿气透过率来控制透皮给药系统的给药速率和概况。