1-Cyclopropyl-7-(1,7-diaza-spiro[4.4]non-7-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid | 128244-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Cyclopropyl-7-(1,7-diaza-spiro[4.4]non-7-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
• 英文别名: 1-Cyclopropyl-7-(1,7-diazaspiro[4.4]nonan-7-yl)-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
• CAS: 128244-07-5
• 化学式: C₂₀H₂₁F₂N₃O₃
• 分子量: 389.402
• InChiKey: LIEVRCWTSGGDMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,7-二氮杂螺[4.4]壬烷 、 1-环丙基-6,7,8-三氟-4-氧代-1,4-二氢喹啉-3-羧酸 生成 1-Cyclopropyl-7-(1,7-diaza-spiro[4.4]non-7-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
  参考文献：
  名称：

  CULBERTSON, TOWNLEY P.;SANCHEZ, JOSEPH P.;GAMBINO, LAURA;SESNIE, JOSEPHIN+, J. MED. CHEM., 33,(1990) N, C. 2270-2275

  摘要：

  DOI：

文献信息

• Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships
  作者：Townley P. Culbertson、Joseph P. Sanchez、Laura Gambino、Josephine A. Sesnie

  DOI：10.1021/jm00170a035

  日期：1990.8

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.
• CULBERTSON, TOWNLEY P.;SANCHEZ, JOSEPH P.;GAMBINO, LAURA;SESNIE, JOSEPHIN+, J. MED. CHEM., 33,(1990) N, C. 2270-2275
  作者：CULBERTSON, TOWNLEY P.、SANCHEZ, JOSEPH P.、GAMBINO, LAURA、SESNIE, JOSEPHIN+

  DOI：——

  日期：——