Vermiculin

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Vermiculin
• 英文别名: (7E)-2-acetyl-2,3,4,5-tetrahydrooxonine-6,9-dione
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: ZZNRQUMEJUAXMD-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Vermiculin 在 溶剂黄146 、 锌 作用下， 生成 4,9-dioxodecanoic acid
  参考文献：
  名称：

  信函：ver石的修订结构。一种来自ver青霉的新型大环内酯二内酯抗生素。

  摘要：

  DOI：

  10.1021/ja00825a054

文献信息

• NOVEL ANTIBIOTIC
  申请人：Koninklijke Nederlandse Akademie Van Wetenschappen

  公开号：US20170210722A1

  公开（公告）日：2017-07-27

  The present invention relates to novel compounds, comprising an 8-or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said cyclic structure and to pharmaceutical compositions comprising these compounds. The compounds may be used as medicaments, in particular as medicaments for treating and preventing microbial infections, such as infections by multidrug resistant and/or Gram-positive bacteria. The invention further relates to fermentation processes wherein fungi of the genus Ulocladium are used for producing the novel compounds.
• Novel antibiotic
  申请人：Koninklijke Nederlandse Akademie van Wetenschappen

  公开号：US20190040033A1

  公开（公告）日：2019-02-07

  The present invention relates to novel compounds, comprising an 8- or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said cyclic structure and to pharmaceutical compositions comprising these compounds. The compounds may be used as medicaments, in particular as medicaments for treating and preventing microbial infections, such as infections by multidrug resistant and/or Gram-positive bacteria. The invention further relates to fermentation processes wherein fungi of the genus Ulocladium are used for producing the novel compounds.
• US9920025B2
  申请人：——

  公开号：US9920025B2

  公开（公告）日：2018-03-20
• Revised structure of vermiculine. Novel macrolide dilactone antibiotic from Penicillium vermiculatum
  作者：Robert K. Boeckman、Jose Fayos、Jon Clardy

  DOI：10.1021/ja00825a054

  日期：1974.9