4-oxo-5-methyl-4,5,6,7-tetrahydrobenzothiophene | 19995-43-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-oxo-5-methyl-4,5,6,7-tetrahydrobenzothiophene
• 英文别名: 6,7-dihydro-5-methyl-benzo[b]thiophen-4(5H)-one；5-methyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-one；5-methyl-6,7-dihydro-1-benzothiophen-4(5H)-one；5-methyl-6,7-dihydro-5H-benzo[b]thiophen-4-one；5-Methyl-6,7-dihydro-5H-benzo[b]thiophen-4-on；5-methyl-6,7-dihydro-5H-1-benzothiophen-4-one
• CAS: 19995-43-8
• 化学式: C₉H₁₀OS
• 分子量: 166.244
• InChiKey: VMIZWBVAJZOOAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-oxo-5-methyl-4,5,6,7-tetrahydrobenzothiophene 在 sulfur 作用下， 生成 5-methyl-benzo[b]thiophen-4-ol
  参考文献：
  名称：

  The Synthesis of 5-Methyl-4,7-thionaphthenequinone and Related Compounds

  摘要：

  DOI：

  10.1021/ja01226a006
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 作用下， 生成 4-oxo-5-methyl-4,5,6,7-tetrahydrobenzothiophene
  参考文献：
  名称：

  The Synthesis of 5-Methyl-4,7-thionaphthenequinone and Related Compounds

  摘要：

  DOI：

  10.1021/ja01226a006

文献信息

• Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or
  申请人：American Cyanamid Company

  公开号：US04036979A1

  公开（公告）日：1977-07-19

  This disclosure describes a novel method for improving feed efficiency and accelerating the growth rate of veterinary homothermic animals by administering to said animals a growth-promoting amount of a cycloalkano[b]thien-4-ylurea or thiourea.

  这份披露描述了一种新颖的方法，通过向兽医同温动物投予一定量的环戊烷基硫代脲或硫脲，以提高饲料效率并加快生长速度。
• Substituted aryl 1,4-pyrazine derivatives
  申请人：——

  公开号：US20030144297A1

  公开（公告）日：2003-07-31

  Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.

  揭示了替代基苯基1,4-吡嗪衍生物及其在治疗焦虑症、抑郁症和与压力有关的疾病中的用途。
• [EN] NOVEL PYRDAZINONE HERBICIDES<br/>[FR] NOUVEAUX HERBICIDES À BASE DE PYRIDAZINONE
  申请人：DU PONT

  公开号：WO2017074992A1

  公开（公告）日：2017-05-04

  Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, agricultural compositions containing them and their use as herbicides wherein R1, R2, G and W are as defined in the disclosure, and A is selected from A-1, A-2, A-3, and A-4 and X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, Y1, Y2, and Y4 are as defined in the disclosure.

  公开了Formula 1的化合物，包括所有立体异构体、N-氧化物和盐，含有它们的农业组合物以及它们作为除草剂的用途，其中R1、R2、G和W如披露中所定义，A从A-1、A-2、A-3和A-4中选择，X1、X2、X3、X4、X5、X6、X7、X8、X9、X10、Y1、Y2和Y4如披露中所定义。
• Substituted aryl 1, 4-pyrazine derivatives
  申请人：Verhoest R. Patrick

  公开号：US20050049257A1

  公开（公告）日：2005-03-03

  Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.

  本发明揭示了替代芳基1,4-吡嗪衍生物及其在治疗焦虑症、抑郁症和与压力相关的疾病中的应用。
• SPIRO TETRAHYDRO - BENZOTHIOPHEN DERIVATIVES USEFUL FOR THE TREATMENT NEURODEGENERATIVE DISEASES
  申请人：Ares Trading S.A.

  公开号：US20150111882A1

  公开（公告）日：2015-04-23

  The present invention provide compounds of Formula (I) used as BACE inhibitors for the treatment of neurodegenerative diseases.

  本发明提供了化合物(I)的方案，用作BACE抑制剂，用于治疗神经退行性疾病。