N-[N_α,N_α-bis(carboxymethyl)-L-lysine]-16-mercaptohexadecanamide | 681239-94-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[N_α,N_α-bis(carboxymethyl)-L-lysine]-16-mercaptohexadecanamide
• 英文别名: N~2~,N~2~-Bis(carboxymethyl)-N~6~-(16-sulfanylhexadecanoyl)-L-lysine；(2S)-2-[bis(carboxymethyl)amino]-6-(16-sulfanylhexadecanoylamino)hexanoic acid
• CAS: 681239-94-1
• 化学式: C₂₆H₄₈N₂O₇S
• 分子量: 532.742
• InChiKey: GIASYAZZSODPPA-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  36
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  16-巯基十六烷基酸 在 乙酸肼 、 碳酸氢钠 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 、 锌 作用下， 以 乙二醇二甲醚 、 乙醇 、 氯仿 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 74.25h， 生成 N-[N_α,N_α-bis(carboxymethyl)-L-lysine]-16-mercaptohexadecanamide
  参考文献：
  名称：

  Nitrilotriacetic Acid-Modified Magnetic Nanoparticles as a General Agent to Bind Histidine-Tagged Proteins

  摘要：

  Using Nalpha,Nalpha-bis(carboxymethyl)lysine to react with FePt magnetic nanoparticles, we synthesized the FePt-NTA conjugate, which immobilizes Ni2+ ions and selectively binds to histidine-tagged proteins at concentration as low as 0.5 pM. This simple system serves as a useful alternative to existing protocols for protein separation and also acts as a versatile agent for transporting and anchoring proteins.

  DOI：

  10.1021/ja031776d

文献信息

• Controlled stoichiometric synthesis of DNA–quantum dot conjugates using Ni-mediated coordination chemistry
  作者：Haejin Kwon、Sukmin Hong、Heeyeon Kim、Youngseon Choi、Jaeseung Kim、Rita Song

  DOI：10.1039/c0cc03462b

  日期：——

  An oligonucleotide modified with Ni-nitrilotriacetate (NTA) was successfully synthesized and used for the stoichiometric functionalization of QDs. This synthetic approach allowed for the facile preparation of DNA–QD conjugates with a defined DNA/QD ratio using well-known Ni–histidine coordination chemistry. A FRET based DNA–QD nanoprobe was prepared using this method highlighting the great potential of this synthetic strategy.

  一种用镍-三乙酸（NTA）修饰的寡核苷酸被成功合成，并用于量子点的化学计量功能化。这种合成方法利用众所周知的镍-组氨酸配位化学，可以轻松制备具有特定DNA/QD比的DNA-QD共轭物。使用这种方法制备了一种基于荧光共振能量转移（FRET）的DNA-QD纳米探针，凸显了这种合成策略的巨大潜力。
• Nitrilotriacetic Acid-Modified Magnetic Nanoparticles as a General Agent to Bind Histidine-Tagged Proteins
  作者：Chenjie Xu、Keming Xu、Hongwei Gu、Xiaofen Zhong、Zhihong Guo、Rongkun Zheng、Xixiang Zhang、Bing Xu

  DOI：10.1021/ja031776d

  日期：2004.3.1

  Using Nalpha,Nalpha-bis(carboxymethyl)lysine to react with FePt magnetic nanoparticles, we synthesized the FePt-NTA conjugate, which immobilizes Ni2+ ions and selectively binds to histidine-tagged proteins at concentration as low as 0.5 pM. This simple system serves as a useful alternative to existing protocols for protein separation and also acts as a versatile agent for transporting and anchoring proteins.