ethyl 6,8-difluoro-1,4-dihydro-1-(1-hydroxyprop-2-yl)-7-(4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylate | 113933-54-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 6,8-difluoro-1,4-dihydro-1-(1-hydroxyprop-2-yl)-7-(4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylate
• 英文别名: Ethyl 6,8-difluoro-1-(1-hydroxypropan-2-yl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylate
• CAS: 113933-54-3
• 化学式: C₂₀H₂₅F₂N₃O₄
• 分子量: 409.433
• InChiKey: LOMPAYMKESMQFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  73.3
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  ethyl 6,8-difluoro-1,4-dihydro-1-(1-hydroxyprop-2-yl)-7-(4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylate 以47%的产率得到
  参考文献：
  名称：

  EGAWA HIROSHI; MIYAMOTO TERUYUKI; MATSUMOTO JUN-ICHI, CHEM. AND PHARM. BULL., 34,(1986) N 10, 4098-4102

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl (Z)-3-(1-hydroxypropan-2-ylamino)-2-[2,3,5-trifluoro-4-(4-methylpiperazin-1-yl)benzoyl]prop-2-enoate 以51%的产率得到
  参考文献：
  名称：

  EGAWA HIROSHI; MIYAMOTO TERUYUKI; MATSUMOTO JUN-ICHI, CHEM. AND PHARM. BULL., 34,(1986) N 10, 4098-4102

  摘要：

  DOI：

文献信息

• A new synthesis of 7H-pyrido(1,2,3-de)(1,4)benzoxazine derivatives including an antibacterial agent, ofloxacin.
  作者：HIROSHI EGAWA、TERUYUKI MIYAMOTO、JUN-ICHI MATSUMOTO

  DOI：10.1248/cpb.34.4098

  日期：——

  A new method for the synthesis of 7H-pyrido[1, 2, 3-de][1, 4]benzoxazine derivatives was developed. The method is characterized by the intramolecular cyclization of 1-(1-hydroxyprop-2-yl)-8-fluoro-4-quinolones which are prepared in three or four steps from ethyl 2, 3, 4, 5-tetrafluoro-benzoylacetate. As an application of this method, ofloxacin, an antibacterial agent, was synthesized.

  一种合成 7H-吡啶并[1，2，3-de][1，4]苯并恶嗪衍生物的新方法被开发出来。该方法的特点是 1-(1-羟基丙-2-基)-8-氟-4-喹诺酮的分子内环化，而这些喹诺酮是由 2, 3, 4, 5-四氟苯甲酰基乙酸乙酯分三或四步制备的。应用这种方法合成了抗菌剂氧氟沙星。
• EGAWA HIROSHI; MIYAMOTO TERUYUKI; MATSUMOTO JUN-ICHI, CHEM. AND PHARM. BULL., 34,(1986) N 10, 4098-4102
  作者：EGAWA HIROSHI、 MIYAMOTO TERUYUKI、 MATSUMOTO JUN-ICHI

  DOI：——

  日期：——
• EHGAVA, XIROSI;MIYAMOTO, AKIYUKI;MATSUMOTO, DZYUNITI
  作者：EHGAVA, XIROSI、MIYAMOTO, AKIYUKI、MATSUMOTO, DZYUNITI

  DOI：——

  日期：——
• PROCESS FOR OBTAINING LEVOFLOXACIN FREE FROM SALTS
  申请人：Quimica Sintetica, S.A.

  公开号：EP1831230B1

  公开（公告）日：2008-12-03
• Process For Obtaining Levofloxacin Free From Salts
  申请人：Palomo Nicolau Francisco

  公开号：US20090069560A1

  公开（公告）日：2009-03-12

  This invention relates to a process for obtaining levofloxacin free from salts. In this process the starting product used is the compound (V), alkaline hydrolysis of which within a water-(C 1 -C 4 )alcohol mixture, and subsequent neutralisation and separation of the salts, leads to levofloxacin free from salts, without need to carry out any final step of extraction and without using halogenated solvents. One characteristic of the process described is that no extractions are necessary in the final step of the process.