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    首页 分子通 按物质功能分类 原料药 循环系统用药 抗心律失常药

    抗心律失常药

    抗心律失常药物主要用于防治过速性心律失常。近年来，随着电生理学研究的深入，对抗心律失常药物的作用机制有了更深刻的认识；同时，体内含量微量测定法的应用使得我们能够依据药代动力学原则制定有效的用药方案。通过连续监测心电图并借助计算机技术评估血药浓度与临床疗效的关系，这些进展极大地促进了新药的研发及心律失常的治疗。

    根据抗心律失常药物的电生理学特点，人们提出了多种分类方法。目前通常将其分为四类：膜稳定剂、动作电位时程和不应期延长剂、β-受体阻断药以及钙拮抗剂。也有学者将前两类称为非特异性抗心律失常药，而后两类则归为特异性抗心律失常药。

    中文名称 英文名称 CAS号 化学式 结构式图片
    普萘洛尔 propranolol 525-66-6 C16H21NO2
    普萘洛尔
    普拉洛尔 practolol 6673-35-4 C14H22N2O3
    普拉洛尔
    左布诺洛尔 levobunolol 47141-42-4 C17H25NO3
    左布诺洛尔
    尼非卡兰 Nifekalant 130636-43-0 C19H27N5O5
    尼非卡兰
    富马酸比索洛尔 bisoprolol Fumarate 104344-23-2 C4H4O4*C18H31NO4
    富马酸比索洛尔
    安他唑啉 antazoline 91-75-8 C17H19N3
    安他唑啉
    妥卡尼 tocainide 41708-72-9 C11H16N2O
    妥卡尼
    奎尼丁硫酸盐 quinidine sulfate 747-45-5 2C20H24N2O2*H2O4S
    奎尼丁硫酸盐
    奎尼丁 quinidine 56-54-2 C20H24N2O2
    奎尼丁
    多非利特 dofetilide 115256-11-6 C19H27N3O5S2
    多非利特
    塞利洛尔 celiprolol 56980-93-9 C20H33N3O4
    塞利洛尔
    噻吗洛尔 timolol 26839-75-8 C13H24N4O3S
    噻吗洛尔
    吲哚洛尔 1-(1H-indol-4-yloxy)-3-(isopropylamino)-2-propanol 13523-86-9 C14H20N2O2
    吲哚洛尔
    吡西卡尼 pilsicainide 88069-67-4 C17H24N2O
    吡西卡尼
    去甲基衡州乌药碱 higenamine 5843-65-2 C16H17NO3
    去甲基衡州乌药碱
    卡替洛尔 carteolol 51781-06-7 C16H24N2O3
    卡替洛尔
    决奈达隆 dronedarone 141626-36-0 C31H44N2O5S
    决奈达隆
    倍他索洛尔 betaxolol 63659-18-7 C18H29NO3
    倍他索洛尔
    伊布利特 ibutilide 122647-31-8 C20H36N2O3S
    伊布利特
    N-乙酰普鲁卡因胺 N-acetylprocainamide 32795-44-1 C15H23N3O2
    N-乙酰普鲁卡因胺
    N-(4-氯苯基)-n-(1-异丙基-4-哌啶)苯乙酰胺盐酸盐 Lorcainide hydrochloride 58934-46-6 C22H27ClN2O*ClH
    N-(4-氯苯基)-n-(1-异丙基-4-哌啶)苯乙酰胺盐酸盐
    5-对甲苯基-1H-四氮唑 5-(p-tolyl)-1H-tetrazole 24994-04-5 C8H8N4
    5-对甲苯基-1H-四氮唑
    1-[2-[2-羟基-3-(丙氨基)-丙氧基]苯基]-3-苯基-1-丙酮 propafenone 54063-53-5 C21H27NO3
    1-[2-[2-羟基-3-(丙氨基)-丙氧基]苯基]-3-苯基-1-丙酮
    (+)-鹰爪豆碱 sparteine 492-08-0 C15H26N2
    (+)-鹰爪豆碱
    —— (R)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid 50-54-4 C40H50N4O8S
    (R)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid
    —— (S)-[(2R,5R)-5-ethylquinuclidin-2-yl]-(6-methoxy-4-quinolyl)methanol 1435-55-8 C20H26N2O2
    (S)-[(2R,5R)-5-ethylquinuclidin-2-yl]-(6-methoxy-4-quinolyl)methanol
    —— (S)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid 7054-25-3 C26H36N2O9
    (S)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
    —— Quinaglute (TN) 7054-25-3 C26H36N2O9
    Quinaglute (TN)
    —— (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid 50-54-4 C40H50N4O8S
    (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid
    —— (+)-sparteine 90-39-1 C15H26N2
    (+)-sparteine
    —— (R)-Timolol (maleate) 26791-17-3 C17H28N4O7S
    (R)-Timolol (maleate)
    —— (2R,3R)-2,3-dihydroxybutanedioate;[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-propan-2-ylazanium 56392-17-7 C34H56N2O12
    (2R,3R)-2,3-dihydroxybutanedioate;[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-propan-2-ylazanium
    —— Quinidine Sulfate 50-54-4 C40H50N4O8S
    Quinidine Sulfate
    —— β-isosparteine 90-39-1 C15H26N2
    β-isosparteine
    —— Spartein 90-39-1 C15H26N2
    Spartein
    —— α-Isospartein 90-39-1 C15H26N2
    α-Isospartein
    —— (+)-sparteine 90-39-1 C15H26N2
    (+)-sparteine
    —— Quinidine sulfate dihydrate 6591-63-5 C40H54N4O10S
    Quinidine sulfate dihydrate
    —— (-)-sparteine 90-39-1 C15H26N2
    (-)-sparteine
    —— bis{1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol} (2E)-but-2-enedioic acid 104344-23-2 C40H66N2O12
    bis{1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol} (2E)-but-2-enedioic acid
    —— (S)-[(4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid 7054-25-3 C26H36N2O9
    (S)-[(4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
    —— (S)-(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol;sulfuric acid 50-54-4 C40H50N4O8S
    (S)-(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol;sulfuric acid
    —— Bisoprolol; butenedioic acid 104344-23-2 C22H35NO8
    Bisoprolol; butenedioic acid
    —— R-Timolol 2-butenedioate 26839-77-0 C17H28N4O7S
    R-Timolol 2-butenedioate
    —— (2R,3S)-2,3-dihydroxybutanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol 56392-17-7 C34H56N2O12
    (2R,3S)-2,3-dihydroxybutanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
    —— (1R,2R,9S,10S)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane;sulfuric acid 6160-12-9 C15H28N2O4S
    (1R,2R,9S,10S)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane;sulfuric acid
    —— Azimilide hydrochloride 149888-94-8 C23H30Cl3N5O3
    Azimilide hydrochloride
    —— Isosparteine, alpha 90-39-1 C15H26N2
    Isosparteine, alpha
    —— 1-(Isopropylamino)-3-(p-[beta-methoxyethyl]phenoxy)-2-propanol tartrate 56392-17-7 C34H56N2O12
    1-(Isopropylamino)-3-(p-[beta-methoxyethyl]phenoxy)-2-propanol tartrate
    —— quinine 50-54-4 C20H24N2O2
    quinine