叠氮(N3)是一种含氮的化合物,通常作为中间体在有机合成中使用。叠氮化合物具有较强的亲核性,在化学反应中可以与金属、碳氢键等发生反应。此外,叠氮还可以用于制备其他重要的有机分子和药物。值得注意的是,叠氮本身是剧毒物质,处理时需要特别小心,避免吸入其蒸气或误食。
在生物医药领域,叠氮化合物被应用于多种研究和技术中,例如,在叠氮化物标记技术(Azide-Click Chemistry)中,叠氮基团可以在温和条件下与炔烃发生环加成反应形成1,2-二取代的四氢呋喃衍生物。这项技术常用于蛋白质、核酸和细胞膜表面的标记。
此外,叠氮化合物还被用作抑制剂研究潜在药物靶点,如对病毒复制酶的作用等。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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2,6-二(4-叠氮苯亚甲基)-4甲基环己酮 | 2,6-bis(4-azidobenzylidene-yl)-4-methylcyclohenxanone | 5284-79-7 | C21H18N6O |
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2,5-脱水-1-叠氮-1-脱氧-D-葡萄糖醇 | 2,5-anhydro-1-azido-1-deoxy-D-glucitol | 243469-59-2 | C6H11N3O4 |
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2,4,6-三异丙基苯磺酰叠氮化物 | 2,4,6-Triisopropylbenzenesulfonyl azide | 36982-84-0 | C15H23N3O2S |
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2'-叠氮-2'-脱氧-5-甲基尿苷 | 2′-azido-2′-deoxy-5-methyluridine | 97748-75-9 | C10H13N5O5 |
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1H-咪唑-1-磺酰叠氮 | 1H-imidazole-1-sulfonyl azide | 952234-37-6 | C3H3N5O2S |
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17-叠氮-3,6,9,12,15-五氧杂十七烷-1-胺 | 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-amine | 516493-93-9 | C12H26N4O5 |
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1-氨基-11-叠氮-3,6,9-三氧杂十一烷 | 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine | 134179-38-7 | C8H18N4O3 |
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1-叠氮烷(4-哌啶基)甲酮 | 1-(Piperidin-4-ylcarbonyl)azepane | 86542-89-4 | C12H22N2O |
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1-叠氮-4-氯苯 | 1-azido-4-chlorobenzene | 3296-05-7 | C6H4ClN3 |
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1-[(3-叠氮基丙氧基)磺酰基]-4-甲基苯 | 3-azidopropyl 4-methylbenzenesulfonate | 153207-76-2 | C10H13N3O3S |
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1,5-二叠氮-9-壬烯[5.5]十一烷 | 1,5-dioxa-9-azaspiro[5.5]undecane | 180-94-9 | C8H15NO2 |
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1,5,7-三氮杂双环[4.4.0]癸-5-烯 | 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine | 5807-14-7 | C7H13N3 |
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1,4-二叠氮烷-1-基(2-噻吩)甲酮 | (1,4-diazepan-1-yl)(thiophen-2-yl)methanone | 683274-51-3 | C10H14N2OS |
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1,4-二叠氮双环[2.2.2]辛烷 | N,N'-diphenylethylenediamine | 150-61-8 | C14H16N2 |
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1,3,5-三乙基六氢-S-三叠氮 | 1,3,5-triethyl-1,3,5-triazacyclohexane | 7779-27-3 | C9H21N3 |
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(S)-2-叠氮-3-苯基丙酸 二环己基铵盐 | (S)-2-azido-3-phenylpropionic acid (dicyclohexylammonium) salt | 79410-36-9 | C9H9N3O2*C12H23N |
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(R)-2-(叠氮甲基)-1-叔丁氧羰基-吡咯烷 | (2R)-2-azidomethyl-N-Boc-pyrrolidine | 259537-91-2 | C10H18N4O2 |
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(5R)-5-(叠氮甲基)-3-(3-氟苯基)-2-恶唑烷酮 | (R)-[3-(3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl azide | 149524-44-7 | C10H9FN4O2 |
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(4S)-4-[(1R)-2-叠氮-1-(苄氧基)乙基]-2,2-二甲基-1,3-二氧戊环 | (4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane | 1228077-93-7 | C14H19N3O3 |
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(3S,5S)-5-[(1S,3S)-1-叠氮基-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-苄基]二氢-3-异丙基-2(3H)-呋喃酮 | (3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one | 324763-46-4 | C25H39N3O5 |
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(3S,5S)-5-((1S,3S)-1-叠氮-3-羟甲基-4-甲基戊基)-3-异丙基二氢呋喃-2(3H)-酮 | (3S,5S)-5-[(1S,3S)-1-azido-3-(hydroxymethyl)-4-methylpentyl]-3-isopropyldihydrofuran-2(3H)-one | 173154-03-5 | C14H25N3O3 |
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—— | Phthalocyanatodichlorosilane | 19333-10-9 | C32H16Cl2N8Si |
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—— | [4-(2,3,4-trihydroxybenzoyl)phenyl] 6-(diazenyldiazenyl)-5-oxo-8H-naphthalene-1-sulfonate | 68510-93-0 | C23H16N4O8S |
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—— | 4,4\'-Diazidostilbene-2,2\'-disulfonic acid disodium salt | 2718-90-3 | C14H8N6Na2O6S2 |
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—— | 2-[2-azido-2-(4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-3-methyl-butyraldehyde | 173154-02-4 | C14H23N3O3 |
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—— | 2-acetamido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-β-D-glucopyranosyl azide | 80887-27-0 | C22H24N4O5 |
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—— | 4-amino-1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one | 84472-89-9 | C9H12N6O3 |
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—— | 2,6-Bis-p-azidobenzyliden-cyclohexanon | 20237-98-3 | C20H16N6O |
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—— | 2,6-bis(4-azidobenzylidene)-4-methylcyclohexanone | 5284-79-7 | C21H18N6O |
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—— | 2,6-bis-(4'-Azidobenzal)-4-methylcyclohexanon | 5284-79-7 | C21H18N6O |
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—— | p-Diazo-n,n-diethylaniline ZINC chloride | 6217-19-2 | C10H14Cl3N3Zn |
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—— | 2-Azidoethyl 2-acetamido-2-deoxy-alpha-L-gulopyranoside | 142072-12-6 | C10H18N4O6 |
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—— | 4-Azido-cinnamaldehyd | 22736-78-3 | C9H7N3O |
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—— | 2,6-bis(4-azidobenzylidene)cyclohexanone | 20237-98-3 | C20H16N6O |
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—— | (S)-2-azido-4-tert-butoxy-4-oxobutanoic acid | 333366-23-7 | C8H13N3O4 |
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—— | 5-(Azidomethyl)-3-(3-fluorophenyl)-1,3-oxazolidin-2-one | 149524-44-7 | C10H9FN4O2 |
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—— | 4-azidosalicylic acid | 66761-27-1 | C7H5N3O3 |
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—— | (2R,3R,4S,5S,6R)-2-(2-Azido-ethoxy)-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol | 165331-08-8 | C8H15N3O6 |
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—— | 5-(phenylazo)salicylic acid | 3147-53-3 | C13H10N2O3 |
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—— | 11-azido-3,6,9-trioxa-undecanyl p-toluenesulfonate | 168640-82-2 | C15H23N3O6S |
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—— | (2S,4S)-4-azido-2-isopropyl-4-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]butanal | 173154-02-4 | C14H23N3O3 |
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—— | 6-azido-6-deoxy-D-glucose | 20847-05-6 | C6H11N3O5 |
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