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    首页 分子通 按分子结构分类 有机化合物 苯丙烷和聚酮 大环内酰胺类

    大环内酰胺类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-2-oxo-1,2,3,4-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C31H29ClF2N4O4
    methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-2-oxo-1,2,3,4-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— (14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carboxylic acid —— C30H26ClF2N3O4
    (14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carboxylic acid
    —— (10R,14S)-5-amino-14-[4-(3-chloro-2,6-difluorophenyl)-2-oxopyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C29H25ClF2N4O2
    (10R,14S)-5-amino-14-[4-(3-chloro-2,6-difluorophenyl)-2-oxopyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— methyl N-[(12E,15S)-15-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-8-oxo-9,17-diazatricyclo[14.3.1.02,7]icosa-1(20),2(7),3,5,12,16,18-heptaen-5-yl]carbamate —— C31H27ClF2N4O4
    methyl N-[(12E,15S)-15-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-8-oxo-9,17-diazatricyclo[14.3.1.02,7]icosa-1(20),2(7),3,5,12,16,18-heptaen-5-yl]carbamate
    —— (10R,14S)-14-[4-[3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one —— C30H27ClFN7O2
    (10R,14S)-14-[4-[3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one
    —— methyl N-[(10R,14S)-14-[4-(6-chloropyridin-2-yl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C30H30ClN5O4
    methyl N-[(10R,14S)-14-[4-(6-chloropyridin-2-yl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— N-(4-chloro-3-fluoro-2-{1-[(10R,14S)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-1,2,3,6-tetrahydropyridin-4-yl}phenyl)acetamide —— C31H30ClFN4O3
    N-(4-chloro-3-fluoro-2-{1-[(10R,14S)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-1,2,3,6-tetrahydropyridin-4-yl}phenyl)acetamide
    —— methyl N-[(10R,14S)-14-[4-(6-acetyl-3-chloro-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-17-fluoro-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaen-5-yl]carbamate —— C34H32ClF2N3O5
    methyl N-[(10R,14S)-14-[4-(6-acetyl-3-chloro-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-17-fluoro-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaen-5-yl]carbamate
    —— methyl N-[(10R,14S)-14-[4-(2-methoxyphenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(18),2,4,6,15(19),16-hexaen-5-yl]carbamate —— C32H34N4O5
    methyl N-[(10R,14S)-14-[4-(2-methoxyphenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(18),2,4,6,15(19),16-hexaen-5-yl]carbamate
    —— 4-chloro-3-fluoro-2-[1-[(10R,14S)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]benzonitrile —— C30H26ClFN4O2
    4-chloro-3-fluoro-2-[1-[(10R,14S)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]benzonitrile
    —— (10R,14S)-14-[4-(3-chloro-2-fluoro-6-pyridin-4-ylphenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one —— C34H30ClFN4O2
    (10R,14S)-14-[4-(3-chloro-2-fluoro-6-pyridin-4-ylphenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one
    —— (10R,14S)-14-{4-[3-chloro-2-fluoro-6-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-6-oxo-1,2,3,6-tetrahydropyridin-1-yl}-4-fluoro-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C30H26ClF2N7O2
    (10R,14S)-14-{4-[3-chloro-2-fluoro-6-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-6-oxo-1,2,3,6-tetrahydropyridin-1-yl}-4-fluoro-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— methyl N-[(10R,14S)-14-[4-(5-chloro-2-methoxyphenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C32H33ClN4O5
    methyl N-[(10R,14S)-14-[4-(5-chloro-2-methoxyphenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— methyl N-[(10R,14S)-14-amino-17-methoxy-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C21H26N4O4
    methyl N-[(10R,14S)-14-amino-17-methoxy-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— methyl (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaene-4-carboxylate —— C31H28ClF2N3O4
    methyl (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaene-4-carboxylate
    —— (10R,14S)-14-[4-(3-chloro-2-fluorophenyl)-2-oxopyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one —— C29H25ClFN3O2
    (10R,14S)-14-[4-(3-chloro-2-fluorophenyl)-2-oxopyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one
    —— methyl (10R,14S)-14-[4-(6-bromo-3-chloro-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate —— C32H29BrClFN2O4
    methyl (10R,14S)-14-[4-(6-bromo-3-chloro-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate
    —— methyl N-[(10R,14S)-14-[4-(3-chloro-6-cyano-2-fluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,18-diazatricyclo[13.3.1.02,7]nonadeca-1(18),2(7),3,5,15(19),16-hexaen-5-yl]carbamate —— C32H29ClFN5O4
    methyl N-[(10R,14S)-14-[4-(3-chloro-6-cyano-2-fluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,18-diazatricyclo[13.3.1.02,7]nonadeca-1(18),2(7),3,5,15(19),16-hexaen-5-yl]carbamate
    —— (10R,14S)-5-amino-4-bromo-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one —— C29H26BrClF2N4O2
    (10R,14S)-5-amino-4-bromo-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one
    —— methyl N-[(10R,14S)-14-[4-[5-chloro-2-(trifluoromethyl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C32H30ClF3N4O4
    methyl N-[(10R,14S)-14-[4-[5-chloro-2-(trifluoromethyl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— (14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carbonitrile —— C30H25ClF2N4O2
    (14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carbonitrile
    —— (10R,14S)-5-amino-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-4-fluoro-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C29H26ClF3N4O2
    (10R,14S)-5-amino-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-4-fluoro-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-5-[[(4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C35H37ClF2N4O6
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-5-[[(4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— 4-chloro-2-[1-[(10R,14S)-3,5-difluoro-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]-3-fluorobenzonitrile —— C30H24ClF3N4O2
    4-chloro-2-[1-[(10R,14S)-3,5-difluoro-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]-3-fluorobenzonitrile
    —— methyl N-[(15S)-15-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-9-oxo-8,17-diazatricyclo[14.3.1.02,7]icosa-1(20),2(7),3,5,16,18-hexaen-5-yl]carbamate —— C31H29ClF2N4O4
    methyl N-[(15S)-15-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-9-oxo-8,17-diazatricyclo[14.3.1.02,7]icosa-1(20),2(7),3,5,16,18-hexaen-5-yl]carbamate
    —— methyl N-[(10S,14S)-14-amino-17-methoxy-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C21H26N4O4
    methyl N-[(10S,14S)-14-amino-17-methoxy-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— N-(4-chloro-3-fluoro-2-{1-[(10R,14S)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-1,2,3,6-tetrahydropyridin-4-yl}phenyl)-2,2,2-trifluoroacetamide —— C31H27ClF4N4O3
    N-(4-chloro-3-fluoro-2-{1-[(10R,14S)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-1,2,3,6-tetrahydropyridin-4-yl}phenyl)-2,2,2-trifluoroacetamide
    —— US9951071, Example 226 —— C32H40N4O4
    US9951071, Example 226
    —— (14S)-14-[4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carboxamide —— C31H27ClF4N4O3
    (14S)-14-[4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carboxamide
    —— 2-[1-[(10R,14S)-3,4-difluoro-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]-3-fluorobenzene-1,4-dicarbonitrile —— C31H24F3N5O2
    2-[1-[(10R,14S)-3,4-difluoro-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]-3-fluorobenzene-1,4-dicarbonitrile
    —— (9R,13S)-13-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-4-cyclopropyl-9-methyl-2,3,7,15-tetrazatricyclo[12.3.1.02,6]octadeca-1(18),4,6,14,16-pentaen-8-one —— C29H28ClF2N5O2
    (9R,13S)-13-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-4-cyclopropyl-9-methyl-2,3,7,15-tetrazatricyclo[12.3.1.02,6]octadeca-1(18),4,6,14,16-pentaen-8-one
    —— 2-fluoro-3-[1-[(10R,14S)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]benzene-1,4-dicarbonitrile —— C31H26FN5O2
    2-fluoro-3-[1-[(10R,14S)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]benzene-1,4-dicarbonitrile
    —— tert-butyl N-[(10R,11E,14S)-17-methoxy-5-(methoxycarbonylamino)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,11,15,17-heptaen-14-yl]carbamate —— C26H32N4O6
    tert-butyl N-[(10R,11E,14S)-17-methoxy-5-(methoxycarbonylamino)-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,11,15,17-heptaen-14-yl]carbamate
    —— US9951071, Example 29 —— C30H27BrClFN4O3
    US9951071, Example 29
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-4-(hydroxymethyl)-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C30H28ClF2N3O3
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-4-(hydroxymethyl)-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-5-(pyridin-2-ylamino)-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C34H30ClF2N5O2
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-5-(pyridin-2-ylamino)-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— (13R,17S)-17-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-6,13-dimethyl-12-oxo-7,11,19-triazatetracyclo[16.3.1.02,10.04,8]docosa-1(22),2(10),3,5,8,18,20-heptaene-5-carboxylic acid —— C33H29ClF2N4O4
    (13R,17S)-17-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-6,13-dimethyl-12-oxo-7,11,19-triazatetracyclo[16.3.1.02,10.04,8]docosa-1(22),2(10),3,5,8,18,20-heptaene-5-carboxylic acid
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylic acid —— C31H27ClF2N2O4
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylic acid
    —— methyl (10R,14S)-14-[4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-4-carboxylate —— C32H28ClF4N3O4
    methyl (10R,14S)-14-[4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-4-carboxylate
    —— methyl N-[(10R,14S)-14-[4-(3-chloro-6-cyano-2-fluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9,17-dioxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(18),2(7),3,5,15(19)-pentaen-5-yl]carbamate —— C32H29ClFN5O5
    methyl N-[(10R,14S)-14-[4-(3-chloro-6-cyano-2-fluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9,17-dioxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(18),2(7),3,5,15(19)-pentaen-5-yl]carbamate
    —— methyl N-[(10R,14S)-14-[4-(2-aminopyridin-4-yl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C30H32N6O4
    methyl N-[(10R,14S)-14-[4-(2-aminopyridin-4-yl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— (10R,14S)-14-[4-[3-chloro-6-(1,3-dimethylpyrazol-4-yl)-2-fluorophenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one —— C34H33ClFN5O2
    (10R,14S)-14-[4-[3-chloro-6-(1,3-dimethylpyrazol-4-yl)-2-fluorophenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one
    —— (13R,17S)-17-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-6,13-dimethyl-7,11,19-triazatetracyclo[16.3.1.02,10.04,8]docosa-1(22),2(10),3,5,8,18,20-heptaen-12-one —— C32H29ClF2N4O2
    (13R,17S)-17-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-6,13-dimethyl-7,11,19-triazatetracyclo[16.3.1.02,10.04,8]docosa-1(22),2(10),3,5,8,18,20-heptaen-12-one
    —— methyl N-[(14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-hydroxy-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C31H29ClF2N4O5
    methyl N-[(14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-hydroxy-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— (14S)-14-[4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carboxylic acid —— C31H26ClF4N3O4
    (14S)-14-[4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carboxylic acid
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-12,3,6-tetrahydropyridin-1-yl]-5-(hydroxymethyl)-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C30H28ClF2N3O3
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-12,3,6-tetrahydropyridin-1-yl]-5-(hydroxymethyl)-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— methyl (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate —— C32H29ClF2N2O4
    methyl (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaen-9-one —— C30H27ClF2N2O2
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaen-9-one
    —— methyl N-[(10R,14S)-14-[4-(6-bromo-3-chloro-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaen-5-yl]carbamate —— C32H30BrClFN3O4
    methyl N-[(10R,14S)-14-[4-(6-bromo-3-chloro-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaen-5-yl]carbamate
    —— 2-[5-[[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]amino]-1,3,4-oxadiazol-2-yl]acetonitrile —— C33H28ClF2N7O3
    2-[5-[[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]amino]-1,3,4-oxadiazol-2-yl]acetonitrile