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    首页 分子通 按分子结构分类 有机化合物 苯丙烷和聚酮 大环内酰胺类

    大环内酰胺类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 1-[(1S,4R,7Z,14R,18R)-4-(cyclopropylsulfonylcarbamoyl)-2,15-dioxo-14-(2-oxo-2-piperidin-1-ylethyl)-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-18-yl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid —— C38H51N5O8S
    1-[(1S,4R,7Z,14R,18R)-4-(cyclopropylsulfonylcarbamoyl)-2,15-dioxo-14-(2-oxo-2-piperidin-1-ylethyl)-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-18-yl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid
    —— 2-[(1S,4R,7E,14R,18R)-18-(8-chloro-7-methoxy-2-pyridin-2-ylquinolin-4-yl)oxy-4-(cyclopropylsulfonylcarbamoyl)-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-14-yl]-3,3-dimethylbutanoic acid —— C42H50ClN5O9S
    2-[(1S,4R,7E,14R,18R)-18-(8-chloro-7-methoxy-2-pyridin-2-ylquinolin-4-yl)oxy-4-(cyclopropylsulfonylcarbamoyl)-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-14-yl]-3,3-dimethylbutanoic acid
    —— (1S,4R,7E,14R,18R)-N-cyclopropylsulfonyl-14-[2-(3,3-difluorocyclohexyl)-2-oxoethyl]-18-[7-methoxy-8-methyl-2-[2-(propan-2-ylamino)-1,3-thiazol-4-yl]quinolin-4-yl]oxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxamide —— C46H58F2N6O8S2
    (1S,4R,7E,14R,18R)-N-cyclopropylsulfonyl-14-[2-(3,3-difluorocyclohexyl)-2-oxoethyl]-18-[7-methoxy-8-methyl-2-[2-(propan-2-ylamino)-1,3-thiazol-4-yl]quinolin-4-yl]oxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxamide
    —— (4E,6Z,10E)-9-[amino(hydroxy)methoxy]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10-tetraene-3,20,22-trione —— C31H47N3O8
    (4E,6Z,10E)-9-[amino(hydroxy)methoxy]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10-tetraene-3,20,22-trione
    —— 9,10,29,30-Tetrabutoxy-3,6,13,17,22,26-hexazatricyclo[26.2.2.28,11]tetratriaconta-1(30),8,10,28,31,33-hexaene-2,7,12,27-tetrone —— C44H70N6O8
    9,10,29,30-Tetrabutoxy-3,6,13,17,22,26-hexazatricyclo[26.2.2.28,11]tetratriaconta-1(30),8,10,28,31,33-hexaene-2,7,12,27-tetrone
    —— 1-N-[3-[22-[3-[[2,3-dihydroxy-4-(2-methoxyethylcarbamoyl)benzoyl]amino]propyl]-14,15,29,30-tetrahydroxy-2,12,17,27-tetraoxo-3,7,11,18,22,26-hexazatricyclo[26.2.2.213,16]tetratriaconta-1(30),13,15,28,31,33-hexaen-7-yl]propyl]-2,3-dihydroxy-4-N-(2-methoxyethyl)benzene-1,4-dicarboxamide —— C56H74N10O18
    1-N-[3-[22-[3-[[2,3-dihydroxy-4-(2-methoxyethylcarbamoyl)benzoyl]amino]propyl]-14,15,29,30-tetrahydroxy-2,12,17,27-tetraoxo-3,7,11,18,22,26-hexazatricyclo[26.2.2.213,16]tetratriaconta-1(30),13,15,28,31,33-hexaen-7-yl]propyl]-2,3-dihydroxy-4-N-(2-methoxyethyl)benzene-1,4-dicarboxamide
    —— 2,3-dibutoxy-4-N-(2-methoxyethyl)-1-N-[3-[14,15,29,30-tetrabutoxy-22-[5-[2,3-dibutoxy-4-(2-methoxyethylcarbamoyl)phenyl]-5-oxopentyl]-2,12,17,27-tetraoxo-3,7,11,18,22,26-hexazatricyclo[26.2.2.213,16]tetratriaconta-1(30),13,15,28,31,33-hexaen-7-yl]propyl]benzene-1,4-dicarboxamide —— C89H139N9O18
    2,3-dibutoxy-4-N-(2-methoxyethyl)-1-N-[3-[14,15,29,30-tetrabutoxy-22-[5-[2,3-dibutoxy-4-(2-methoxyethylcarbamoyl)phenyl]-5-oxopentyl]-2,12,17,27-tetraoxo-3,7,11,18,22,26-hexazatricyclo[26.2.2.213,16]tetratriaconta-1(30),13,15,28,31,33-hexaen-7-yl]propyl]benzene-1,4-dicarboxamide
    —— 2,3-dibutoxy-4-N-(2-methoxyethyl)-1-N-[2-[12,13,25,26-tetrabutoxy-19-[2-[[2,3-dibutoxy-4-(2-methoxyethylcarbamoyl)benzoyl]amino]ethyl]-2,10,15,23-tetraoxo-3,6,9,16,19,22-hexazatricyclo[22.2.2.211,14]triaconta-1(26),11,13,24,27,29-hexaen-6-yl]ethyl]benzene-1,4-dicarboxamide —— C82H126N10O18
    2,3-dibutoxy-4-N-(2-methoxyethyl)-1-N-[2-[12,13,25,26-tetrabutoxy-19-[2-[[2,3-dibutoxy-4-(2-methoxyethylcarbamoyl)benzoyl]amino]ethyl]-2,10,15,23-tetraoxo-3,6,9,16,19,22-hexazatricyclo[22.2.2.211,14]triaconta-1(26),11,13,24,27,29-hexaen-6-yl]ethyl]benzene-1,4-dicarboxamide
    —— 1-N-[2-[19-[2-[[2,3-dihydroxy-4-(2-methoxyethylcarbamoyl)benzoyl]amino]ethyl]-12,13,25,26-tetrahydroxy-2,10,15,23-tetraoxo-3,6,9,16,19,22-hexazatricyclo[22.2.2.211,14]triaconta-1(26),11,13,24,27,29-hexaen-6-yl]ethyl]-2,3-dihydroxy-4-N-(2-methoxyethyl)benzene-1,4-dicarboxamide —— C50H62N10O18
    1-N-[2-[19-[2-[[2,3-dihydroxy-4-(2-methoxyethylcarbamoyl)benzoyl]amino]ethyl]-12,13,25,26-tetrahydroxy-2,10,15,23-tetraoxo-3,6,9,16,19,22-hexazatricyclo[22.2.2.211,14]triaconta-1(26),11,13,24,27,29-hexaen-6-yl]ethyl]-2,3-dihydroxy-4-N-(2-methoxyethyl)benzene-1,4-dicarboxamide
    —— tert-butyl N-[2-[12,13,25,26-tetrabutoxy-19-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]-2,10,15,23-tetraoxo-3,6,9,16,19,22-hexazatricyclo[22.2.2.211,14]triaconta-1(26),11,13,24,27,29-hexaen-6-yl]ethyl]carbamate —— C54H88N8O12
    tert-butyl N-[2-[12,13,25,26-tetrabutoxy-19-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]-2,10,15,23-tetraoxo-3,6,9,16,19,22-hexazatricyclo[22.2.2.211,14]triaconta-1(26),11,13,24,27,29-hexaen-6-yl]ethyl]carbamate
    —— tert-butyl N-[3-[14,15,29,30-tetrabutoxy-22-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-2,12,17,27-tetraoxo-3,7,11,18,22,26-hexazatricyclo[26.2.2.213,16]tetratriaconta-1(30),13,15,28,31,33-hexaen-7-yl]propyl]carbamate —— C60H100N8O12
    tert-butyl N-[3-[14,15,29,30-tetrabutoxy-22-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-2,12,17,27-tetraoxo-3,7,11,18,22,26-hexazatricyclo[26.2.2.213,16]tetratriaconta-1(30),13,15,28,31,33-hexaen-7-yl]propyl]carbamate
    —— 4-[22-[2,3-dihydroxy-4-(2-methoxyethylcarbamoyl)benzoyl]-9,10,29,30-tetrahydroxy-2,7,12,27-tetraoxo-3,6,13,17,22,26-hexazatricyclo[26.2.2.28,11]tetratriaconta-1(30),8,10,28,31,33-hexaene-17-carbonyl]-2,3-dihydroxy-N-(2-methoxyethyl)benzamide —— C50H60N8O18
    4-[22-[2,3-dihydroxy-4-(2-methoxyethylcarbamoyl)benzoyl]-9,10,29,30-tetrahydroxy-2,7,12,27-tetraoxo-3,6,13,17,22,26-hexazatricyclo[26.2.2.28,11]tetratriaconta-1(30),8,10,28,31,33-hexaene-17-carbonyl]-2,3-dihydroxy-N-(2-methoxyethyl)benzamide
    —— 1-hydroxy-6-oxo-N-[2-[12,13,25,26-tetrahydroxy-19-[2-[(1-hydroxy-6-oxopyridine-2-carbonyl)amino]ethyl]-2,10,15,23-tetraoxo-3,6,9,16,19,22-hexazatricyclo[22.2.2.211,14]triaconta-1(26),11,13,24,27,29-hexaen-6-yl]ethyl]pyridine-2-carboxamide —— C40H46N10O14
    1-hydroxy-6-oxo-N-[2-[12,13,25,26-tetrahydroxy-19-[2-[(1-hydroxy-6-oxopyridine-2-carbonyl)amino]ethyl]-2,10,15,23-tetraoxo-3,6,9,16,19,22-hexazatricyclo[22.2.2.211,14]triaconta-1(26),11,13,24,27,29-hexaen-6-yl]ethyl]pyridine-2-carboxamide
    —— 1-N-[3-[22-[3-[[2,3-dihydroxy-4-[(2-methoxyethylamino)methyl]benzoyl]amino]propyl]-14,15,29,30-tetrahydroxy-2,12,17,27-tetraoxo-3,7,11,18,22,26-hexazatricyclo[26.2.2.213,16]tetratriaconta-1(30),13,15,28,31,33-hexaen-7-yl]propyl]-2,3-dihydroxy-4-N-(2-methoxyethyl)benzene-1,4-dicarboxamide —— C56H76N10O17
    1-N-[3-[22-[3-[[2,3-dihydroxy-4-[(2-methoxyethylamino)methyl]benzoyl]amino]propyl]-14,15,29,30-tetrahydroxy-2,12,17,27-tetraoxo-3,7,11,18,22,26-hexazatricyclo[26.2.2.213,16]tetratriaconta-1(30),13,15,28,31,33-hexaen-7-yl]propyl]-2,3-dihydroxy-4-N-(2-methoxyethyl)benzene-1,4-dicarboxamide
    —— 2,3-dibutoxy-N-(2-methoxyethyl)-4-[9,10,29,30-tetrabutoxy-22-[2,3-dibutoxy-4-(2-methoxyethylcarbamoyl)benzoyl]-2,7,12,27-tetraoxo-3,6,13,17,22,26-hexazatricyclo[26.2.2.28,11]tetratriaconta-1(30),8,10,28,31,33-hexaene-17-carbonyl]benzamide —— C82H124N8O18
    2,3-dibutoxy-N-(2-methoxyethyl)-4-[9,10,29,30-tetrabutoxy-22-[2,3-dibutoxy-4-(2-methoxyethylcarbamoyl)benzoyl]-2,7,12,27-tetraoxo-3,6,13,17,22,26-hexazatricyclo[26.2.2.28,11]tetratriaconta-1(30),8,10,28,31,33-hexaene-17-carbonyl]benzamide
    —— 20-Fluoro-8,8-dimethyl-7,14-dioxo-15-oxa-21-thia-2,3,6,22-tetrazatetracyclo[14.3.1.12,4.110,13]docosa-1(19),3,10,12,16(20),17-hexaene-19-carboximidamide —— C19H19FN6O3S
    20-Fluoro-8,8-dimethyl-7,14-dioxo-15-oxa-21-thia-2,3,6,22-tetrazatetracyclo[14.3.1.12,4.110,13]docosa-1(19),3,10,12,16(20),17-hexaene-19-carboximidamide
    —— (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-(1-aminoethenoxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaene-3,20,22-trione —— C32H45N3O7
    (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-(1-aminoethenoxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaene-3,20,22-trione
    —— 4-Amino-18,20-dimethyl-10-methylidene-7-thia-3,5,11,15-tetrazatricyclo[15.3.1.12,6]docosa-1(21),2(22),3,5,17,19-hexaen-16-one —— C20H25N5OS
    4-Amino-18,20-dimethyl-10-methylidene-7-thia-3,5,11,15-tetrazatricyclo[15.3.1.12,6]docosa-1(21),2(22),3,5,17,19-hexaen-16-one
    —— [(4E,6Z,8S,9R,10E,12S,13R,14S,16S,17R)-9-carbamoyloxy-22-hydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-20-yl] N-methyl-N-[2-(methylamino)ethyl]carbamate —— C35H54N4O9
    [(4E,6Z,8S,9R,10E,12S,13R,14S,16S,17R)-9-carbamoyloxy-22-hydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-20-yl] N-methyl-N-[2-(methylamino)ethyl]carbamate
    —— (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-amino-9-(1-aminoethenoxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaene-3,20,22-trione —— C29H41N3O7
    (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-amino-9-(1-aminoethenoxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaene-3,20,22-trione
    —— [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] formate —— C32H47N3O8
    [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] formate
    —— 10-Fluoro-8-(methylamino)-2-oxa-23-thia-4,6,15,20,25,28,29-heptazapentacyclo[22.2.2.13,14.05,13.07,12]nonacosa-1(27),3,5(13),7(12),8,10,14(29),24(28),25-nonaen-21-one —— C21H21FN8O2S
    10-Fluoro-8-(methylamino)-2-oxa-23-thia-4,6,15,20,25,28,29-heptazapentacyclo[22.2.2.13,14.05,13.07,12]nonacosa-1(27),3,5(13),7(12),8,10,14(29),24(28),25-nonaen-21-one
    —— (16R)-16-(aminomethyl)-10-fluoro-19-methyl-8-(methylamino)-2,18-dioxa-24-thia-4,6,15,21,26,29,30-heptazapentacyclo[23.2.2.13,14.05,13.07,12]triaconta-1(28),3,5(13),7(12),8,10,14(30),25(29),26-nonaen-22-one —— C23H26FN9O3S
    (16R)-16-(aminomethyl)-10-fluoro-19-methyl-8-(methylamino)-2,18-dioxa-24-thia-4,6,15,21,26,29,30-heptazapentacyclo[23.2.2.13,14.05,13.07,12]triaconta-1(28),3,5(13),7(12),8,10,14(30),25(29),26-nonaen-22-one
    —— (5R)-24-fluoro-22-(methylamino)-8-oxo-10,16-dioxa-2,7,18,20,28-pentazahexacyclo[15.10.1.12,5.111,15.019,27.021,26]triaconta-1(28),11(29),12,14,17,19(27),21(26),22,24-nonaene-13-carbonitrile —— C25H22FN7O3
    (5R)-24-fluoro-22-(methylamino)-8-oxo-10,16-dioxa-2,7,18,20,28-pentazahexacyclo[15.10.1.12,5.111,15.019,27.021,26]triaconta-1(28),11(29),12,14,17,19(27),21(26),22,24-nonaene-13-carbonitrile
    —— methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-17-fluoro-10-methyl-9-oxo-8-azatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C32H29ClF3N3O4
    methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-17-fluoro-10-methyl-9-oxo-8-azatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— US9951071, Example 194 —— C31H29ClF2N4O4
    US9951071, Example 194
    —— 2-[1-[(10R,14S)-4,5-difluoro-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]-3-fluorobenzene-1,4-dicarbonitrile —— C31H24F3N5O2
    2-[1-[(10R,14S)-4,5-difluoro-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]-3-fluorobenzene-1,4-dicarbonitrile
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-4,5-difluoro-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one —— C29H24ClF4N3O2
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-4,5-difluoro-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one
    —— methyl (10R,14R)-14-[4-(6-bromo-3-chloro-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate —— C32H29BrClFN2O4
    methyl (10R,14R)-14-[4-(6-bromo-3-chloro-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-3,5-difluoro-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C29H24ClF4N3O2
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-3,5-difluoro-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-3-methyl-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C32H31ClF2N4O4
    methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-3-methyl-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— (9R,13S)-13-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-9-methyl-4,5,7,15-tetrazatricyclo[12.3.1.02,6]octadeca-1(18),2(6),3,14,16-pentaen-8-one —— C26H24ClF2N5O2
    (9R,13S)-13-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-9-methyl-4,5,7,15-tetrazatricyclo[12.3.1.02,6]octadeca-1(18),2(6),3,14,16-pentaen-8-one
    —— methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9,11-dioxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C31H27ClF2N4O5
    methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9,11-dioxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— 4-chloro-2-[1-[(10R,14S)-3,4-difluoro-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]-3-fluorobenzonitrile —— C30H24ClF3N4O2
    4-chloro-2-[1-[(10R,14S)-3,4-difluoro-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-14-yl]-6-oxo-2,3-dihydropyridin-4-yl]-3-fluorobenzonitrile
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-5-(pyridin-3-ylamino)-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C34H30ClF2N5O2
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-5-(pyridin-3-ylamino)-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-3-fluoro-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C29H25ClF3N3O2
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-3-fluoro-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— methyl N-[(10R,14S)-14-[4-(6-bromo-2-fluoro-3-methylphenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C32H32BrFN4O4
    methyl N-[(10R,14S)-14-[4-(6-bromo-2-fluoro-3-methylphenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— (10R,14S)-14-{4-[5-chloro-2-(1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1,2,3,6-tetrahydropyridin-1-yl} - 10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C31H29ClN6O2
    (10R,14S)-14-{4-[5-chloro-2-(1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1,2,3,6-tetrahydropyridin-1-yl} - 10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-3,4-difluoro-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C29H24ClF4N3O2
    (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-3,4-difluoro-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— (10R,14S)-5-bromo-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C29H25BrClF2N3O2
    (10R,14S)-5-bromo-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— US9951071, Example 94 —— C30H27BrClFN4O4
    US9951071, Example 94
    —— (10R,14S)-14-{4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo-1,2,3,6-tetrahydropyridin-1-yl}-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaene-4-carboxylic acid —— C31H26ClF4N3O4
    (10R,14S)-14-{4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo-1,2,3,6-tetrahydropyridin-1-yl}-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaene-4-carboxylic acid
    —— methyl N-[(10R,14S)-14-[4-(3-methoxyphenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate —— C32H34N4O5
    methyl N-[(10R,14S)-14-[4-(3-methoxyphenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate
    —— (14S)-14-[4-(6-acetyl-3-chloro-2-fluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carboxamide —— C32H30ClFN4O4
    (14S)-14-[4-(6-acetyl-3-chloro-2-fluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-5-carboxamide
    —— methyl (10R,14S)-14-[4-(6-bromo-3-chloro-2-fluorophenyl)-2-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate —— C32H29BrClFN2O4
    methyl (10R,14S)-14-[4-(6-bromo-3-chloro-2-fluorophenyl)-2-oxo-1,2,3,6-tetrahydropyridin-1-yl]-10-methyl-9-oxo-8-azatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate
    —— methyl (10R,14S)-5-amino-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate —— C31H29ClF2N4O4
    methyl (10R,14S)-5-amino-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaene-4-carboxylate
    —— (10R,14S)-14-{4-[5-chloro-2-(1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1,2,3,6-tetrahydropyridin-1-yl}-4-fluoro-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one —— C31H28ClFN6O2
    (10R,14S)-14-{4-[5-chloro-2-(1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1,2,3,6-tetrahydropyridin-1-yl}-4-fluoro-10-methyl-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one
    —— (10S,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-propan-2-yl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one —— C31H30ClF2N3O2
    (10S,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-propan-2-yl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaen-9-one
    —— methyl N-[(10R,14S)-14-[4-(3-chloro-6-cyano-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-17-methoxy-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(18),2,4,6,15(19),16-hexaen-5-yl]carbamate —— C33H31ClFN5O5
    methyl N-[(10R,14S)-14-[4-(3-chloro-6-cyano-2-fluorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-1-yl]-17-methoxy-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.0<sup>2</sup>'<sup>7</sup>]nonadeca-1(18),2,4,6,15(19),16-hexaen-5-yl]carbamate
    —— methyl (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaene-3-carboxylate —— C31H28ClF2N3O4
    methyl (10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-6-oxo-2,3-dihydropyridin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2,4,6,15,17-hexaene-3-carboxylate