4-(3-Dimethylaminomethyl-4-oxo-chroman-2-yl)-benzonitrile; hydrochloride | 77038-34-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 4-(3-Dimethylaminomethyl-4-oxo-chroman-2-yl)-benzonitrile; hydrochloride
• CAS: 77038-34-7
• 化学式: C₁₉H₁₈N₂O₂*ClH
• 分子量: 342.825
• InChiKey: JWIZKEVZRKDJRG-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-(3-Dimethylaminomethyl-4-oxo-chroman-2-yl)-benzonitrile; hydrochloride 以 水 为溶剂， 反应 2.0h， 以4%的产率得到4'-cyano-3-methylene flavanone
  参考文献：
  名称：

  Antimicrobial 3-methylene flavanones

  摘要：

  The antimicrobial activity previously attributed to flavanone Mannich bases was found to be due to their breakdown products, 3-methyleneflavanones. Among the latter compounds, highest potency was observed when the flavanone phenyl ring contained bromine or chlorine substituents. 3-Methylene-2-phenylflavanone (8) was synthesized and shown to be equal to hexachlorophene in tests against representative Gram-positive microorganisms.

  DOI：

  10.1021/jm00141a011