trans-nonachlor | 39765-80-5

• 物质功能分类: 分析化学 - 标准品 - 挥发性有机化合物(VOCs)
• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: trans-nonachlor
• CAS: 39765-80-5
• 化学式: C₁₀H₅Cl₉
• 分子量: 444.227
• InChiKey: OCHOKXCPKDPNQU-DFACZZRHSA-N

物化性质

• 熔点：
  148℃
• 沸点：
  522.25°C (rough estimate)
• 密度：
  1.7470 (rough estimate)
• 闪点：
  -26 °C

安全信息

• 危险品标志：
  F,N,Xn
• 安全说明：
  S16,S26,S29,S33,S36,S36/37,S61,S62,S9
• 危险类别码：
  R11,R67,R22,R51/53,R48/20,R62,R65,R50,R36,R38,R20/21/22
• WGK Germany：
  3
• 危险品运输编号：
  UN 1208 3/PG 2

制备方法与用途

用途

反式九氯是一种有机氯杀虫剂，主要应用于农业生产中防治农作物病虫害。

类别

农药

毒性分级

中毒

急性毒性

口服- 大鼠 LD50: 500 毫克/ 公斤

可燃性危险特性

燃烧产生有毒氯化物气体

储运特性

库房通风低温干燥; 与食品原料分开储运

灭火剂

干粉、泡沫、砂土

反应信息

• 作为反应物：
  描述：

  trans-nonachlor 以 1,4-二氧六环 、 水 为溶剂， 生成 MC5
  参考文献：
  名称：

  北化学实验室—XXXI：氯丹化学反应

  摘要：

  工业用氯丹的纯净成分以固体膜的形式在空气，溶剂，水和空气存在下以及在240-578 mu范围内的气相中以固体膜的形式被辐照。除了已知的桥接化合物以外，还通过光谱方法分离和鉴定了光化学反应的其他主要产物。这些产品主要是脱氯产品及其桥连化合物。

  DOI：

  10.1016/s0040-4020(01)90719-7

文献信息

• [EN] PFKFB3 INHIBITORS AND THEIR USES<br/>[FR] INHIBITEURS DE PFKFB3 ET LEURS UTILISATIONS
  申请人：GERO DISCOVERY LLC

  公开号：WO2020080979A1

  公开（公告）日：2020-04-23

  This disclosure relates to new phthalimide and isoindolinone derivatives and other PFKFB3 inhibitors for use in the treatment of diseases. The invention further relates to pharmaceutical compositions containing such PFKFB3 inhibitors, methods of preparation thereof, methods for their use as therapeutic agents, and methods of preparation of a medicament for use in therapy, as well as kits and other inventiions comprising such PFKFB3 inhibitors. These PFKFB3 inhibitors are useful for the treatment and prophylaxis of cancer, neurodegenerative diseases, autoimmune diseases, inflammatory disorders, multiple sclerosis, metabolic diseases, inhibition of angiogenesis and other diseases and conditions, where the modulation of PFKFB3 and/or PFKFB4 has beneficial effect as well as neuroprotection.

  这项披露涉及新的邻苯二甲酰亚胺和异吲哚酮衍生物以及其他PFKFB3抑制剂，用于治疗疾病。该发明还涉及含有此类PFKFB3抑制剂的药物组合物，其制备方法，作为治疗剂的使用方法，以及用于治疗的药物的制备方法，以及包含此类PFKFB3抑制剂的工具包和其他发明。这些PFKFB3抑制剂对于治疗和预防癌症、神经退行性疾病、自身免疫疾病、炎症性疾病、多发性硬化症、代谢性疾病、抑制血管生成以及其他疾病和情况具有用途，在这些情况下，PFKFB3和/或PFKFB4的调节具有益处，以及神经保护作用。
• Instruments for detecting low-molecular weight substance
  申请人：Mizukami Haruki

  公开号：US20050148097A1

  公开（公告）日：2005-07-07

  To provide the following instruments 1 and 2 as a low-molecular-weight substance detection instrument employing immunochromatography capable of detecting conveniently and sensitively detecting a low-molecular weight substance such as an environmental pollutant (e.g., a dioxin), as a target substance contained in a test sample: 1. an instrument, which comprises 1) a test sample application section with which a test sample is brought into contact; 2) a label product reaction section containing a label product containing, as a portion thereof, an antibody capable of binding to a target substance contained in the test sample, the label product being not bound to the reaction section; 3) an unbound label product capturing section containing an element capable of capturing the label product which is not bound to the target substance, the element being bound to the capturing section; and 4) a detection section containing a detection element which, when coming into contact with the target substance bound to the label product, causes a visually observable change, and 2. an instrument wherein a test sample is reacted with a labeled antibody containing, as a portion thereof, an antibody capable of binding to a target substance contained in the test sample, and the resultant reaction product is employed for detecting the target substance contained in the test sample.

  提供以下仪器1和2作为低分子量物质检测仪器，采用免疫层析技术，能够方便敏感地检测低分子量物质，例如环境污染物（例如二恶英），作为测试样品中包含的目标物质：1. 仪器，包括1）测试样品应用部分，用于将测试样品接触；2）标签产物反应部分，包含一种标签产物，其中包含一种能够结合到测试样品中的目标物质的抗体，标签产物未结合到反应部分；3）未结合标签产物捕获部分，包含一种能够捕获未结合到目标物质的标签产物的元素，该元素与捕获部分结合；以及4）检测部分，包含一种检测元素，当与结合到标签产物的目标物质接触时，会引起可视的变化；2. 仪器，其中测试样品与标记抗体反应，其中一部分包含能够结合到测试样品中的目标物质的抗体，产生的反应产物用于检测测试样品中包含的目标物质。
• METHOD AND BIOSENSOR FOR DETECTING ANTIGEN
  申请人：EBARA CORPORATION

  公开号：EP1143251A1

  公开（公告）日：2001-10-10

  A sensor chip for surface plasmon resonance which has a thin metal film, an antibody against a substance with the steroid skeleton such as a steroid hormone, a sex hormone or an environmental hormone (excluding triazine compounds), and a fixation layer for fixing the antibody to the thin metal film; and a method for detecting an environmental hormone which involves the step of exposing the antibody in the above-mentioned sensor chip to a sample, the step of irradiating the thin metal film with light and the step of determining the intensity of the light reflected by the thin metal film. This method achieves a high sensitivity and an excellent selectivity.

  一种用于表面等离子体共振的传感器芯片，它具有一层金属薄膜，一种针对类固醇激素、性激素或环境激素（不包括三嗪化合物）等具有类固醇骨架的物质的抗体，以及一层用于将抗体固定在金属薄膜上的固定层；以及一种检测环境激素的方法，它包括将上述传感器芯片中的抗体暴露在样品中的步骤、用光照射金属薄膜的步骤和测定金属薄膜反射光强度的步骤。这种方法灵敏度高，选择性好。
• Method of removing exogenous endocrine-disrupting chemical in water
  申请人：Hitachi Plant Engineering & Construction Co., Ltd.

  公开号：EP1227065A2

  公开（公告）日：2002-07-31

  Biological treatment for an environmental hormone in water can be efficiently performed by use of a microorganism-immobilized carrier is provided. To biologically remove an environmental hormonal substance in water by a microorganism-immobilized carrier having microorganism immobilized onto a carrier. The microorganism-immobilized carrier is formed of an immobilizing material prepared by mixing and polymerizing a hydrophilic prepolymer and a hydrophobic prepolymer or prepared by polymerizing a prepolymer having a hydrophilic group and a hydrophobic group in a molecule.

  通过使用微生物固定化载体，可以有效地对水中的环境激素进行生物处理。利用微生物固定载体对水中的环境激素物质进行生物去除，该载体上固定有微生物。微生物固定化载体由亲水性预聚物和疏水性预聚物混合聚合制备的固定化材料形成，或由分子中具有亲水基团和疏水基团的预聚物聚合制备的固定化材料形成。
• DRUGS, DRINKS OR FOODS
  申请人：Takara Shuzo Co, Ltd.

  公开号：EP1232756A1

  公开（公告）日：2002-08-21

  Remedies or preventives for diseases caused by the binding of agonists (endocrine disruptors, etc.) to the estrogen receptor, characterized by containing, as the active ingredient, antagonists such as catechins (for example, epigallocatechin gallate) having the antagonism to the estrogen receptor agonists.

  治疗或预防因激动剂（内分泌干扰素等）与雌激素受体结合而引起的疾病的药物，其特征是含有拮抗剂，如儿茶素（例如表没食子儿茶素没食子酸酯）作为活性成分，具有拮抗雌激素受体激动剂的作用。