7-Chloro-2,4-dimethyl-1,4-dihydro-2H-isoquinoline-3-thione | 167384-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-Chloro-2,4-dimethyl-1,4-dihydro-2H-isoquinoline-3-thione
• CAS: 167384-15-8
• 化学式: C₁₁H₁₂ClNS
• 分子量: 225.742
• InChiKey: NYMAEFVAVIWHHP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  1-戊烯-3-酮 、 7-Chloro-2,4-dimethyl-1,4-dihydro-2H-isoquinoline-3-thione 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以95%的产率得到1-(7-Chloro-2,4-dimethyl-3-thioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl)-pentan-3-one
  参考文献：
  名称：

  Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

  摘要：

  A short and efficient six-step synthesis of novel phenanthridin-3-one derivatives is described. The synthesis of these derivatives is highlighted by the cyclization of a suitably placed ketone side chain with a thioiminium ion. The derivatives prepared were found to be inhibitors of human steroid 5-alpha reductase.

  DOI：

  10.1016/0040-4039(95)00690-e
• 作为产物：
  描述：

  7-Chloro-2,4-dimethyl-1,4-dihydro-2H-isoquinolin-3-one 在 劳森试剂 、 吡啶 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以83%的产率得到7-Chloro-2,4-dimethyl-1,4-dihydro-2H-isoquinoline-3-thione
  参考文献：
  名称：

  Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

  摘要：

  A short and efficient six-step synthesis of novel phenanthridin-3-one derivatives is described. The synthesis of these derivatives is highlighted by the cyclization of a suitably placed ketone side chain with a thioiminium ion. The derivatives prepared were found to be inhibitors of human steroid 5-alpha reductase.

  DOI：

  10.1016/0040-4039(95)00690-e