(R)-3-[(R)-2-Allyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionic acid allyl ester | 247912-78-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-3-[(R)-2-Allyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionic acid allyl ester
• CAS: 247912-78-3
• 化学式: C₄₀H₅₄N₄O₁₀S₂
• 分子量: 815.022
• InChiKey: CKVZHYZWZGDMGE-YDPTYEFTSA-N

反应信息

• 作为反应物：
  描述：

  (R)-3-[(R)-2-Allyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionic acid allyl ester 在 吗啉 、 四(三苯基膦)钯 、 三乙胺 、 1,4-二巯基-2,3-丁二醇 作用下， 以 四氢呋喃 为溶剂， 生成 Boc-Phe-Cys(Pal)-OH
  参考文献：
  名称：

  Synthesis of characteristic palmitoylated lipopeptides from human Y1 receptor by a combination of enzyme-labile and Pd(0)-sensitive protecting groups

  摘要：

  Base-labile palmitoylated peptides representing the characteristic lipidated region of human Y-1 receptor were synthesizea via a chemoenzymatic protecting group strategy employing both the enzyme catalyzed cleavage of the choline ester and the Pd(0)mediated removal of the allyl ester as the key steps. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01388-x
• 作为产物：
  描述：

  BOC-L-苯丙氨酸 、 L-Cystine bisallyl ester bis(toluene-4-sulfonate) 在 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 、 三乙胺 作用下， 以87%的产率得到(R)-3-[(R)-2-Allyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionic acid allyl ester
  参考文献：
  名称：

  Synthesis of characteristic palmitoylated lipopeptides from human Y1 receptor by a combination of enzyme-labile and Pd(0)-sensitive protecting groups

  摘要：

  Base-labile palmitoylated peptides representing the characteristic lipidated region of human Y-1 receptor were synthesizea via a chemoenzymatic protecting group strategy employing both the enzyme catalyzed cleavage of the choline ester and the Pd(0)mediated removal of the allyl ester as the key steps. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01388-x