| 1262279-13-9

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• CAS: 1262279-13-9
• 化学式: C₈H₇BFNO₄
• 分子量: 210.957
• InChiKey: TXAOGUJKSQGBEQ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 一水合肼 作用下， 以 甲醇 为溶剂， 生成 6-amino-5-fluoro-3-methylbenzo[c][1,2]oxaborol-1(3H)-ol
  参考文献：
  名称：

  Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease

  摘要：

  We disclose here a series of P4-benzoxaborole-substituted macrocyclic HCV protease inhibitors. These inhibitors are potent against HCV NS3 protease, their anti-HCV replicon potencies are largely impacted by substitutions on benzoxaborole ring system and P2* groups. P2* 2-thiazole-isoquinoline provides best replicon potency. The in vitro SAR studies and in vivo PK evaluations of selected compounds are described herein. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.10.071
• 作为产物：
  描述：

  1,3-Dihydro-5-fluoro-1-hydroxy-3-methyl-2,1-benzoxaborolane 在 硝酸 作用下， 生成
  参考文献：
  名称：

  Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease

  摘要：

  We disclose here a series of P4-benzoxaborole-substituted macrocyclic HCV protease inhibitors. These inhibitors are potent against HCV NS3 protease, their anti-HCV replicon potencies are largely impacted by substitutions on benzoxaborole ring system and P2* groups. P2* 2-thiazole-isoquinoline provides best replicon potency. The in vitro SAR studies and in vivo PK evaluations of selected compounds are described herein. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.10.071