(E)-4-{(4S,6R)-6-[(2S,5R,6R)-8-(2,2-Dimethyl-propionyloxy)-2,6-dihydroxy-5-methyl-octyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-but-2-enoic acid methyl ester | 672906-41-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-4-{(4S,6R)-6-[(2S,5R,6R)-8-(2,2-Dimethyl-propionyloxy)-2,6-dihydroxy-5-methyl-octyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-but-2-enoic acid methyl ester
• CAS: 672906-41-1
• 化学式: C₂₅H₄₄O₈
• 分子量: 472.62
• InChiKey: GPVPMEXBRLVJNY-FBWCSUTMSA-N

物化性质

• 沸点：
  566.7±45.0 °C(Predicted)
• 密度：
  1.058±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  (E)-4-{(4S,6R)-6-[(2S,5R,6R)-8-(2,2-Dimethyl-propionyloxy)-2,6-dihydroxy-5-methyl-octyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-but-2-enoic acid methyl ester 在 吡啶 、 4-二甲氨基吡啶 、 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 反应 10.0h， 生成 (E)-(5S,7S,9S,12R,13R)-15-(2,2-Dimethyl-propionyloxy)-5,7-dihydroxy-12-methyl-9,13-bis-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentadec-2-enoic acid methyl ester
  参考文献：
  名称：

  Absolute Stereochemistry of Immunosuppressive Macrolide Brasilinolide A and Its New Congener Brasilinolide C

  摘要：

  Brasilinolide A (2) is a 32-membered polyhydroxyl macrolide with immunosuppressive activity isolated from a pathogenic actinomycete, Nocardia brasiliensis IFM0406. The absolute configurations at 26 chiral centers of 2 and its new congener, brasilinolide C (1), were determined on the basis of the spectral data of 1 and degradation products derived from 1 and degration products derived from 1and 2.

  DOI：

  10.1021/jo035773v
• 作为产物：
  描述：

  2,2-二甲氧基丙烷 、 (E)-(5S,7R,9S,12R,13R)-15-(2,2-Dimethyl-propionyloxy)-5,7,9,13-tetrahydroxy-12-methyl-pentadec-2-enoic acid methyl ester 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 0.67h， 以0.4 mg的产率得到(E)-4-{(4S,6R)-6-[(2S,5R,6R)-8-(2,2-Dimethyl-propionyloxy)-2,6-dihydroxy-5-methyl-octyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-but-2-enoic acid methyl ester
  参考文献：
  名称：

  Absolute Stereochemistry of Immunosuppressive Macrolide Brasilinolide A and Its New Congener Brasilinolide C

  摘要：

  Brasilinolide A (2) is a 32-membered polyhydroxyl macrolide with immunosuppressive activity isolated from a pathogenic actinomycete, Nocardia brasiliensis IFM0406. The absolute configurations at 26 chiral centers of 2 and its new congener, brasilinolide C (1), were determined on the basis of the spectral data of 1 and degradation products derived from 1 and degration products derived from 1and 2.

  DOI：

  10.1021/jo035773v