3-<2-(3-Methoxy-benzylidenamino)-ethyl>-indol | 95020-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-<2-(3-Methoxy-benzylidenamino)-ethyl>-indol
• 英文别名: (2-indol-3-yl-ethyl)-(3-methoxy-benzylidene)-amine
• CAS: 95020-97-6
• 化学式: C₁₈H₁₈N₂O
• 分子量: 278.354
• InChiKey: DSUWWAMQHYWXHH-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  3-<2-(3-Methoxy-benzylidenamino)-ethyl>-indol 在 sodium tetrahydroborate 作用下， 以1.1 g的产率得到3-(3-methoxybenzylaminoethyl)-1H-indole
  参考文献：
  名称：

  [EN] NOVEL BENZYLTRYPTAMINE COMPOUNDS
  [FR] NOUVEAUX COMPOSÉS DE BENZYLTRYPTAMINE

  摘要：

  There is disclosed a compound of Formula (I): and any pharmaceutically acceptable salt or zwitterion thereof; wherein: R is hydrogen, methyl or ethyl; R1is hydrogen or C1-C2alkoxy; R2is methyl or a C2-C4group which may be saturated or unsaturated, branched or linear; and R3, R4, R5and R6each are independently selected from hydrogen, hydroxyl, halogen, methyl optionally substituted with hydroxy, methoxy, ethoxy, and a saturated or unsaturated C2-C3that may be optionally substituted with hydroxyl, with the provisos that: (i) at least two of R4, R5, R6and R7must be hydrogen, and (ii) R3, R4, R5and R6may be selected such that an adjacent pair thereof join to form a ring having at least 5 members. The compound of Formula (I) is believed useful in treating a disease or disorder in a subject which may be alleviated by a 5HT2A agonist (e.g., CNS disorders and one or more symptoms of any one of depression, alcoholism, tobacco addiction, cocaine addiction, inflammation, cluster headache and PTSD in a subject).

  公开号：

  WO2023070228A1
• 作为产物：
  描述：

  色胺 、 3-甲氧基苯甲酸酸酐 以 乙醇 为溶剂， 生成 3-<2-(3-Methoxy-benzylidenamino)-ethyl>-indol
  参考文献：
  名称：

  [EN] NOVEL BENZYLTRYPTAMINE COMPOUNDS
  [FR] NOUVEAUX COMPOSÉS DE BENZYLTRYPTAMINE

  摘要：

  There is disclosed a compound of Formula (I): and any pharmaceutically acceptable salt or zwitterion thereof; wherein: R is hydrogen, methyl or ethyl; R1is hydrogen or C1-C2alkoxy; R2is methyl or a C2-C4group which may be saturated or unsaturated, branched or linear; and R3, R4, R5and R6each are independently selected from hydrogen, hydroxyl, halogen, methyl optionally substituted with hydroxy, methoxy, ethoxy, and a saturated or unsaturated C2-C3that may be optionally substituted with hydroxyl, with the provisos that: (i) at least two of R4, R5, R6and R7must be hydrogen, and (ii) R3, R4, R5and R6may be selected such that an adjacent pair thereof join to form a ring having at least 5 members. The compound of Formula (I) is believed useful in treating a disease or disorder in a subject which may be alleviated by a 5HT2A agonist (e.g., CNS disorders and one or more symptoms of any one of depression, alcoholism, tobacco addiction, cocaine addiction, inflammation, cluster headache and PTSD in a subject).

  公开号：

  WO2023070228A1