| 1206910-93-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• CAS: 1206910-93-1
• 化学式: C₁₀H₁₀F₃NOS
• 分子量: 249.257
• InChiKey: YFCNINMEAVKMLI-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.71
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.1
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  、 三苯基氯甲烷 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以5.64 g的产率得到(S)-N-{1-[4-(tritylthio)phenyl]ethyl}trifluoroacetamide
  参考文献：
  名称：

  Novel Peptoid Building Blocks: Synthesis of Functionalized Aromatic Helix-Inducing Submonomers

  摘要：

  Peptoids, oligo-N-substituted glycines, can fold into well-defined helical secondary structures. The design and synthesis of new peptoid building blocks that are capable of both (a) inducing a helical secondary structure and (b) decorating the helices with chemical functionalities are reported. Peptoid heptamers containing carboxamide, carboxylic acid or thiol functionalities were synthesized, and the resulting peptoids were shown to form stable helices. A thiol-containing peptoid readily formed the homodisulfide. providing a convenient route to prepare peptoid helix homodimers.

  DOI：

  10.1021/ol902660p
• 作为产物：
  描述：

  (S)-N-{1-[4-(methylsulfinyl)phenyl]ethyl}trifluoroacetamide 在 2,6-二甲基吡啶 、 三氟乙酸酐 、 甲醇 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  Novel Peptoid Building Blocks: Synthesis of Functionalized Aromatic Helix-Inducing Submonomers

  摘要：

  Peptoids, oligo-N-substituted glycines, can fold into well-defined helical secondary structures. The design and synthesis of new peptoid building blocks that are capable of both (a) inducing a helical secondary structure and (b) decorating the helices with chemical functionalities are reported. Peptoid heptamers containing carboxamide, carboxylic acid or thiol functionalities were synthesized, and the resulting peptoids were shown to form stable helices. A thiol-containing peptoid readily formed the homodisulfide. providing a convenient route to prepare peptoid helix homodimers.

  DOI：

  10.1021/ol902660p