| 1201685-73-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• CAS: 1201685-73-5
• 化学式: C₁₆H₂₅F₃O₉S₂
• 分子量: 482.496
• InChiKey: FRAPKYGYFPWUGG-HZSPNIEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.03
• 重原子数：
  30.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  122.27
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  在 sodium azide 作用下， 以 水 、 丙酮 为溶剂， 反应 4.0h， 以81 mg的产率得到ethyl (3R,4S,5S)-4-azido-5-(methanesulfonyloxy)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
  参考文献：
  名称：

  Efficient Formal Synthesis of Oseltamivir Phosphate (Tamiflu) with Inexpensive d-Ribose as the Starting Material

  摘要：

  An efficient formal synthesis of oseltamivir phosphate (Tamiflu) has been achieved in 12 steps with use of the inexpensive and highly abundant D-ribose as the starting material. This concise alternative route does not utilize protecting groups and features the Introduction of 3-pentylidene ketal as the latent 3-pentyl ether, the use of a highly efficient RCM reaction to form the Tamiflu skeleton, and selective functional group manipulations.

  DOI：

  10.1021/ol9024716
• 作为产物：
  描述：

  三氟甲磺酸酐 、 ethyl (3R,4R,5S)-4-hydroxy-5-(methanesulfonyloxy)-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Efficient Formal Synthesis of Oseltamivir Phosphate (Tamiflu) with Inexpensive d-Ribose as the Starting Material

  摘要：

  An efficient formal synthesis of oseltamivir phosphate (Tamiflu) has been achieved in 12 steps with use of the inexpensive and highly abundant D-ribose as the starting material. This concise alternative route does not utilize protecting groups and features the Introduction of 3-pentylidene ketal as the latent 3-pentyl ether, the use of a highly efficient RCM reaction to form the Tamiflu skeleton, and selective functional group manipulations.

  DOI：

  10.1021/ol9024716