11-benzyl-6,11-dihydro-5H-benzo[a]carbazole | 53018-67-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 11-benzyl-6,11-dihydro-5H-benzo[a]carbazole
• CAS: 53018-67-0
• 化学式: C₂₃H₁₉N
• 分子量: 309.411
• InChiKey: QBDHTECEYNFBII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.46
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  4.93
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  11-benzyl-6,11-dihydro-5H-benzo[a]carbazole 在 copper(II) choride dihydrate 、 氧气 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 以93%的产率得到11-Benzyl-11H-benzo[a]carbazole
  参考文献：
  名称：

  Copper-mediated rapid and facile oxidative dehydrogenation of dihydrobenzocarbazoles

  摘要：

  Rapid method for the oxidative dehydrogenation of dihydrobenzocarbazoles has been introduced by using bench scale and commercially available reagent; copper chloride, in excellent yield with easy workup. The scope of the reaction has been studied with broad range of substitutes

  DOI：

  10.1080/00397911.2020.1731757

文献信息

• A one-pot direct regioselective iodination of Fischer-Borsche product using periodic acid in PEG-400
  作者：Monica H. Ghom、Mahavir S. Naykode、Vivek T. Humne、Pradeep D. Lokhande

  DOI：10.1016/j.tetlet.2019.03.022

  日期：2019.4

  A metal-free and greener approach for the one-pot direct iodination and dehydrogenation of dihydrobenzo[a]carbazoles has been developed using periodic acid in polyethylene glycol-400 (PEG-400) under mild condition. This method has been proven to be tolerate to a broad range of functional groups, with good to excellent yields include metal-free inexpensive catalyst, easy work-up, benign reaction condition and high regioselectivity. The solvent has been successfully recycled up to 5 times without any loss of activity in an aqueous medium. (C) 2019 Elsevier Ltd. All rights reserved.
• CN116478083
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