(2R,3R,4S,6S,2'R)-4-Acetoxy-3-acetylamino-6-methoxy-octahydro-[2,2']bipyranyl-6-carboxylic acid methyl ester | 548759-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: (2R,3R,4S,6S,2'R)-4-Acetoxy-3-acetylamino-6-methoxy-octahydro-[2,2']bipyranyl-6-carboxylic acid methyl ester
• CAS: 548759-54-2
• 化学式: C₁₇H₂₇NO₈
• 分子量: 373.403
• InChiKey: XVLHKMHCULXJBH-NMNMXBMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  109.39
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  (2R,3R,4S,6S,2'R)-4-Acetoxy-3-acetylamino-6-methoxy-octahydro-[2,2']bipyranyl-6-carboxylic acid methyl ester 在 Lindlar's catalyst sodium azide 、 Dowex 50W (H⁺) 、 硫酸 、 氢气 、 乙酸酐 、 溶剂黄146 作用下， 以 乙醇 、 叔丁醇 为溶剂， 生成 (2R,3R,4R,2'R)-3-Acetylamino-4-amino-3,4,3',4',5',6'-hexahydro-2H,2'H-[2,2']bipyranyl-6-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir

  摘要：

  We synthesized bicyclic ether sialidase inhibitors Such as tetrahydro-furan-2-yl. tetrahydro-pyran-2-yL and oxepan-2-yl derivatives related to zanamivir. These compounds substituted by diol at the C-3' and C-4' positions resulted in the retention of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. Compound I la in particular showed comparable efficacy in vivo relative to that of oseltamivir phosphate. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01039-9
• 作为产物：
  描述：

  (2S,4S,5S,6R)-5-Acetylamino-4-(tert-butyl-dimethyl-silanyloxy)-6-[(S)-[2-(2,2-diethyl-[1,3]dioxolan-4-yl)-ethoxy]-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-2-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 在 palladium on activated charcoal 吡啶 、 4-二甲氨基吡啶 、 Grubbs catalyst first generation 、 四丁基氟化铵 、 氢气 、 溶剂黄146 、 三甲氧基磷 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 生成 (2R,3R,4S,6S,2'R)-4-Acetoxy-3-acetylamino-6-methoxy-octahydro-[2,2']bipyranyl-6-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir

  摘要：

  We synthesized bicyclic ether sialidase inhibitors Such as tetrahydro-furan-2-yl. tetrahydro-pyran-2-yL and oxepan-2-yl derivatives related to zanamivir. These compounds substituted by diol at the C-3' and C-4' positions resulted in the retention of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. Compound I la in particular showed comparable efficacy in vivo relative to that of oseltamivir phosphate. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01039-9