4-Pentenoic acid, 4-[(dimethylphenylsilyl)methyl]-3-(hydroxymethyl)-,methyl ester | 144602-79-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Pentenoic acid, 4-[(dimethylphenylsilyl)methyl]-3-(hydroxymethyl)-,methyl ester
• 英文别名: Methyl-3-hydroxymethyl-4-dimethylphenylsilylmethylpent-4-enoate
• CAS: 144602-79-9
• 化学式: C₁₆H₂₄O₃Si
• 分子量: 292.45
• InChiKey: MZIUEOJIQHOODI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.33
• 重原子数：
  20.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-Pentenoic acid, 4-[(dimethylphenylsilyl)methyl]-3-(hydroxymethyl)-,methyl ester 在 草酰氯 、 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 以90%的产率得到3-Pentenoic acid, 5-(dimethylphenylsilyl)-3-formyl-4-methyl-, methylester
  参考文献：
  名称：

  Preparation of a highly functionalized allylsilane for use in three-bond cascade reactions

  摘要：

  Preparation of the novel allylsilane, methyl 3-formyl-4-(phenyldimethylsilylmethyl)pent-4-enoate (2) was accomplished in 7 steps from 2,3-dibromopropene. (2) has great potential as an annulating reagent.

  DOI：

  10.1016/s0040-4039(00)61154-1
• 作为产物：
  描述：

  phenyldimethyl(2-bromo-2-propenyl)-silane 在 copper(l) iodide 氢氧化钾 、 magnesium 作用下， 生成 4-Pentenoic acid, 4-[(dimethylphenylsilyl)methyl]-3-(hydroxymethyl)-,methyl ester
  参考文献：
  名称：

  Preparation of a highly functionalized allylsilane for use in three-bond cascade reactions

  摘要：

  Preparation of the novel allylsilane, methyl 3-formyl-4-(phenyldimethylsilylmethyl)pent-4-enoate (2) was accomplished in 7 steps from 2,3-dibromopropene. (2) has great potential as an annulating reagent.

  DOI：

  10.1016/s0040-4039(00)61154-1

文献信息

• Preparation of A Trifunctional Allylsilane for Use in Three-Bond Cascade Reactions
  作者：Gregory J. Hollingworth、late Thomas V. Lee、J. B. Sweeney

  DOI：10.1080/00397919608003719

  日期：1996.3

  The synthesis of trifunctional allylsilane (2b) is described.
• Preparation of a highly functionalized allylsilane for use in three-bond cascade reactions
  作者：Gregory J. Hollingworth、Thomas V. Lee、J.B. Sweeney

  DOI：10.1016/s0040-4039(00)61154-1

  日期：1992.9

  Preparation of the novel allylsilane, methyl 3-formyl-4-(phenyldimethylsilylmethyl)pent-4-enoate (2) was accomplished in 7 steps from 2,3-dibromopropene. (2) has great potential as an annulating reagent.