3-(6-bromo-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione | 1178894-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(6-bromo-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
• CAS: 1178894-40-0
• 化学式: C₃₁H₁₉BrN₄O₄S
• 分子量: 623.486
• InChiKey: RVPHOEBYJCNLHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.93
• 重原子数：
  41.0
• 可旋转键数：
  5.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.27
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  3-(6-bromo-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以76.6%的产率得到3-(6-bromo-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors

  摘要：

  A series of novel 4-azaindolyl-indolyl-maleimides were synthesized and evaluated for their GSK-3 beta inhibitory activity. Most compounds exhibited high potency to GSK-3 beta. Among them, compound 7c was the most promising GSK-3 beta inhibitor. Preliminary structure-activity relationships were discussed based on the experimental data obtained and showed that different substituents on the indole ring and side chains at 1-position of indole had varying degrees of influence on the GSK-3 beta inhibitory potency. In a cell-based functional assay, compounds 7c and 15a significantly reduced A beta-induced Tau hyperphosphorylation by inhibiting GSK-3 beta. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.031
• 作为产物：
  描述：

  4-氮杂吲哚 、 3-(6-bromo-1-benzenesulfonyl-1H-indol-3-yl)-4-chloro-1-phenyl-1H-pyrrole-2,5-dione 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以34.8%的产率得到3-(6-bromo-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors

  摘要：

  A series of novel 4-azaindolyl-indolyl-maleimides were synthesized and evaluated for their GSK-3 beta inhibitory activity. Most compounds exhibited high potency to GSK-3 beta. Among them, compound 7c was the most promising GSK-3 beta inhibitor. Preliminary structure-activity relationships were discussed based on the experimental data obtained and showed that different substituents on the indole ring and side chains at 1-position of indole had varying degrees of influence on the GSK-3 beta inhibitory potency. In a cell-based functional assay, compounds 7c and 15a significantly reduced A beta-induced Tau hyperphosphorylation by inhibiting GSK-3 beta. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.031