2,3-dihydrofuro[2,3-c]pyridin-3-amine | 1211539-44-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-dihydrofuro[2,3-c]pyridin-3-amine
• CAS: 1211539-44-4
• 化学式: C₇H₈N₂O
• 分子量: 136.153
• InChiKey: UZXIEVGCIZTZIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-[(3E)-2H-furo[2,3-c]pyridin-3-ylidene]hydroxylamine 在 ammonium acetate 、 氨 、 锌 作用下， 以 乙醇 为溶剂， 以55.1 %的产率得到2,3-dihydrofuro[2,3-c]pyridin-3-amine
  参考文献：
  名称：

  [EN] GRK2 INHIBITORS AND USES THEREOF
  [FR] INHIBITEURS DE GRK2 ET LEURS UTILISATIONS

  摘要：

  Provided herein are compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, stereoisomers, tautomers, isotopically labeled derivatives, solvates, hydrates, polymorphs, co-crystals, and prodrugs thereof, pharmaceutical compositions thereof, and kits comprising the same. The compounds provided herein are G protein-coupled receptor kinase (e.g., GRK2, GRK3) inhibitors and are therefore useful for, e.g., treating and/or preventing diseases (e.g., cancer) in a subject, for inhibiting tumor growth in a subject, for inhibiting GRK2 and/or GRK3 activity in vitro or in vivo, etc. In certain embodiments, the compounds provided herein are selective for GRK2 and/or GRK3. Also provided herein are methods and synthetic intermediates useful in the preparation of compounds described herein.

  公开号：

  WO2023049438A1

文献信息

• HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
  申请人：Hilpert Kurt

  公开号：US20140163035A1

  公开（公告）日：2014-06-12

  The invention relates to heterocyclic amide derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  本发明涉及公式（I）的杂环酰胺衍生物，其中R1、R2、R3、R4、R5、X、Y和n如描述中所定义，其制备及其作为药用活性化合物的用途。
• [EN] HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS D'AMIDES HÉTÉROCYCLIQUES UTILISÉS COMME ANTAGONISTES DU RÉCEPTEUR P2X7
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2013014587A1

  公开（公告）日：2013-01-31

  The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  该发明涉及公式（I）的杂环酰胺衍生物，其中R1、R2、R3、R4、R5、X、Y和n如描述中所定义，它们的制备以及它们作为药用活性化合物的用途。
• Heterocyclic amide derivatives as P2X7 receptor antagonists
  申请人：Hilpert Kurt

  公开号：US09221832B2

  公开（公告）日：2015-12-29

  The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  本发明涉及公式（I）的杂环酰胺衍生物，其中R1、R2、R3、R4、R5、X、Y和n如描述中所定义，它们的制备和用作药物活性化合物。
• US9221832B2
  申请人：——

  公开号：US9221832B2

  公开（公告）日：2015-12-29