4-Hydroxybenzene-1-sulfonic acid dihydrate | 2060026-75-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Hydroxybenzene-1-sulfonic acid dihydrate
• 英文别名: 4-hydroxybenzenesulfonic acid;dihydrate
• CAS: 2060026-75-5
• 化学式: C6H10O6S
• 分子量: 210.21
• InChiKey: FVULJAPNZJRJMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.01
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  钠 、 4-Hydroxybenzene-1-sulfonic acid dihydrate 、 草酰氯 、 在 乙酸乙酯 、 水 、 氯化钠 、 magnesium sulfate 作用下， 以 N,N-二甲基甲酰胺 、 二氯甲烷 为溶剂， 反应 18.0h， 以6.2 g (100%) of 4-hydroxybenzenesulfonyl chloride are obtained in the form of a colorless oil的产率得到4-羟基苯磺酰氯
  参考文献：
  名称：

  NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS

  摘要：

  本发明涉及一种具有公式（I）结构的苯磺酰胺化合物。本发明还涉及合成这些化合物的方法，以及在人类或兽医药物和化妆品组合物中使用它们的方法。

  公开号：

  US20140107129A1

文献信息

• LUMINESCENT COMPOUNDS
  申请人：Terpetschnig Ewald A.

  公开号：US20120035346A1

  公开（公告）日：2012-02-09

  Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkage are selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye, or a styryl dye.

  基于聚甲烯染料的染料和光致发光化合物，其中至少含有一个烷基膦酸酯或取代烷基膦酸酯基团，包括合成前体、合成方法及其应用。某些实施例包括选择杂环环系统和聚甲烯链结构，以使得所得的聚甲烯染料为青菁染料、美洛青菁染料或偶氮染料。
• Cyanine dyes
  申请人：——

  公开号：US20040014981A1

  公开（公告）日：2004-01-22

  A compound of the formula (I) is provided: (I), wherein Z is O, S, or NR 35 wherein R 35 is H or alkyl; R 1 -R 5 are each independently H, alkyl, halo, carboxyl, amino, or SO 3 31 Cat + , wherein Cat + is a cation and at least one of R 1 -R 5 is SO 3 − Cat + ; R 6 and R 7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR 19 R 20 , wherein R 19 and R 20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R 8 and R 13 are each independently alkyl, (CH 2 ) r R 25 or (CH 2 ) r R 18 ; wherein at least one of R 8 and R 13 (CH 2 ) r R 18 and wherein r is an integer from 1 to 50, and R 25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino or a thiol group, and R 18 is a functional group that can react with 1

  提供公式（I）的化合物：（I），其中Z为O，S或NR35，其中R35为H或烷基；R1-R5独立地为H，烷基，卤素，羧基，氨基或SO331Cat+，其中Cat+为阳离子，并且R1-R5中至少有一个为SO3−Cat+；R6和R7独立地为H，烷基或可选地与它们所连接的（a）基团一起形成环；m和n独立地为0到5的整数；X和Y独立地为O，S，Se或CR19R20，其中R19和R20独立地为烷基，或可选地与它们所连接的碳原子一起形成环；R8和R13独立地为烷基，（CH2）rR25或（ ）rR18；其中R8和R13中至少有一个为（ ）rR18，其中r为1到50的整数，且R25为不直接与羧基，羟基，氨基或巯基反应的功能基团，R18为可与1反应的功能基团。
• OPTICAL FLUORESCENT IMAGING
  申请人：Kovar Joy

  公开号：US20060280688A1

  公开（公告）日：2006-12-14

  Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.

  本发明公开了一种在近红外(NIR)光谱范围内进行非侵入性成像的化合物和方法。 NIR对于肿瘤检测和追踪非常敏感。本申请公开了一种利用配体结合的荧光探针靶向肿瘤富集的细胞表面受体，从而特异性地检测肿瘤相对于动物自发荧光的微不足道。
• Arylsulfonamido-substituted hydroxamic acid derivatives
  申请人：Breitenstein Werner

  公开号：US20080275127A1

  公开（公告）日：2008-11-06

  α-Amino hydroxamic acid derivative of the formula I, in which R is C 2 -C 7 -alkyl, which is mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C 3 -C 5 -cycloalkyl or unsubstituted or substituted C 3 -C 6 -heteroaryl comprising one or two heteroatoms selected from the group consisting of O, S and N; or C 3 -C 7 -alkenyl or C 3 -C 7 -alkynyl, which in each case is unsubstituted or mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C 3 -C 5 -cycloalkyl or unsubstituted or substituted C 3 -C 6 -heteroaryl comprising one or two heteroatoms selected from the group consisting of O, S and N; and the other symbols are as defined in claim 1, are described. These compounds are MMP and in particular MMP2 inhibitors and can be used for treatment of MMP dependent diseases, in particular inflammation conditions, rheumatoid arthritis, osteoarthritis, tumors (tumor growth, metastasis, progression or invasion) and pulmonary disorders (e.g. emphysema, COPD).

  本文描述了公式I的α-氨基羟肟酸衍生物，其中R是C2-C7烷基，可以是单取代、双取代或三取代的卤素、硝基、低酰氧基、三氟甲氧基、氰基、C3-C5环烷基或未取代或取代的C3-C6杂环芳基，其中所述杂环芳基包括一个或两个从O、S和N组成的杂原子；或者是C3-C7烯基或C3-C7炔基，每种情况下都未取代或单取代、双取代或三取代的卤素、硝基、低酰氧基、三氟甲氧基、氰基、C3-C5环烷基或未取代或取代的C3-C6杂环芳基，其中所述杂环芳基包括一个或两个从O、S和N组成的杂原子；其他符号如权利要求1中所定义。这些化合物是MMP，特别是MMP2的抑制剂，并可用于治疗MMP依赖性疾病，特别是炎症病症、类风湿性关节炎、骨关节炎、肿瘤（肿瘤生长、转移、进展或侵袭）和肺部疾病（例如肺气肿、COPD）。
• OPTICAL FLUORESCENT IMAGING IN HISTOLOGY
  申请人：Kovar Joy

  公开号：US20130052637A1

  公开（公告）日：2013-02-28

  Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.

  本发明揭示了在近红外（NIR）光谱范围内进行非侵入性成像所使用的化合物和方法。 NIR对于肿瘤检测和跟踪非常敏感。本申请揭示了使用配体结合的荧光探针靶向肿瘤富集的细胞表面受体，从而特异性地允许检测相对于动物自发荧光的可忽略的肿瘤。