valinomycin | 14295-14-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: valinomycin
• 英文别名: cyclo[OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-Val]；(3S,6S,9R,12R,15S,18S,21R,24R,27S,30S,33S,36R)-6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
• CAS: 14295-14-8
• 化学式: C₅₄H₉₀N₆O₁₈
• 分子量: 1111.34
• InChiKey: FCFNRCROJUBPLU-RPUZOQEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  78
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  332
• 氢给体数：
  6
• 氢受体数：
  18

ADMET

毒理性

• 相互作用

果糖-1,6-二磷酸盐在体外对抗了氯化钾诱导的兔心肌收缩力抑制和瓦利诺霉素诱导的膜去极化。

Fructose-1,6-disphosphate counteracts the inhibition of contractile strength of rabbit cardiac muscle induced by potassium chloride in vitro and valinomycin induced depolarization. ...

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为产物：
  描述：

  L-valyl->L-2-hydroxy-propionyl->L-valyl->D-2-hydroxy-3-methyl-butyryl->D-valyl->L-2-hydroxy-propionyl->L-valyl->D-2-hydroxy-3-methyl-butyryl->D-valyl->L-2-hydroxy-propionyl->L-valyl->D-2-hydroxy-3-methyl-butyric acid; hydrobromide 生成 valinomycin
  参考文献：
  名称：

  Shemyakin,M.M. et al., Journal of general chemistry of the USSR, 1966, vol. 36, p. 1401 - 1412

  摘要：

  DOI：

文献信息

• Voltammetric Ion Sensor
  申请人：Zhang Jie

  公开号：US20080011606A1

  公开（公告）日：2008-01-17

  A method for the quantitative determination of an ion in a fluid which comprises subjecting the fluid to voltammetry using a sensing electrode which comprises an electrically conducting support having a surface which is coated with a support matrix, the support matrix containing an electroactive species capable of being oxidised or reduced to form a charged species, and an ionophore.
• Carbon Nanostructure Electrode Based Sensors: Devices, Processes and Uses Thereof
  申请人：Man Piu Francis

  公开号：US20090278556A1

  公开（公告）日：2009-11-12

  Disclosed herein are methods of preparing and using doped MWNT electrodes, sensors and field-effect transistors. Devices incorporating doped MWNT electrodes, sensors and field-effect transistors are also disclosed. Also disclosed are devices comprising nanostructured electrodes and methods for measuring free chlorine in an aqueous environment. Also disclosed are diamond coated electrodes for use in electrochemical applications.
• CNT-BASED SENSORS: DEVICES, PROCESSES AND USES THEREOF
  申请人：Pace Salvatore J.

  公开号：US20110163296A1

  公开（公告）日：2011-07-07

  Disclosed herein are methods of preparing and using doped MWNT electrodes, sensors and field-effect transistors. Devices incorporating doped MWNT electrodes, sensors and field-effect transistors are also disclosed.
• US7799204B2
  申请人：——

  公开号：US7799204B2

  公开（公告）日：2010-09-21
• US8907384B2
  申请人：——

  公开号：US8907384B2

  公开（公告）日：2014-12-09