2-(1H-imidazol-1-ylmethyl)-1H-imidazole | 1227404-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(1H-imidazol-1-ylmethyl)-1H-imidazole
• 英文别名: 1-(1H-imidazol-2-ylmethyl)imidazole
• CAS: 1227404-44-5
• 化学式: C₇H₈N₄
• 分子量: 148.17
• InChiKey: PQTBEPACVMYXCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4-二氯-5-硝基吡啶 、 2-(1H-imidazol-1-ylmethyl)-1H-imidazole 、 4-(phenylamino)butan-1-ol 、 N,N'-羰基二咪唑 在 钯 作用下， 生成 1-(1H-Imidazol-1-yl)methyl-8-(N-phenyl-(4-hydroxybutyl)amino)imidazo[1,5-a]pyrido[3,4-e]pyrazin-4(5H)-one
  参考文献：
  名称：

  Process for the preparation of imidazoquinoxalinones

  摘要：

  本发明涉及新型咪唑喹喔啉酮及其氮杂环类似物，以及它们的制备方法。本发明的化合物已被发现具有内皮舒张、血管扩张、静脉扩张和其他药理作用。

  公开号：

  US05166344A1

文献信息

• Tricyclic pteridinones and a process for their preparation
  申请人：Berlex Laboratories, Inc.

  公开号：US05602252A1

  公开（公告）日：1997-02-11

  This invention relates to novel tricyclic pteridinones, their aza analogs and their pharmaceutically acceptable salts. Further encompassed by the invention is a novel process for the production of the tricyclic pteridinones and their aza analogs. The compounds of the invention exhibit cardiovascular properties, particularly mixed vasodilation and selective venous and arterial dilation. Pharmaceutical compositions are proposed for the compounds.

  本发明涉及新型三环喜树碱酮、其氮杂环衍生物及其药学上可接受的盐。本发明还涵盖了一种新的生产三环喜树碱酮及其氮杂环衍生物的方法。本发明的化合物表现出心血管特性，特别是混合血管扩张和选择性静脉和动脉扩张。本发明提出了这些化合物的药物组合物。
• Imidazoquinoxalinones, their aza analogs and process for their
  申请人：Berlex Laboratories, Inc.

  公开号：US05055465A1

  公开（公告）日：1991-10-08

  This invention relates to novel imidazoquinoxalinones and their aza analogs and to a process for their preparation. The compounds of this invention have been found to have inodilatory, vasodilatory, venodilatory and other pharmacologic effects.

  本发明涉及新型咪唑喹喔啉酮及其氮杂环衍生物以及它们的制备方法。本发明的化合物被发现具有无嗅性、血管扩张、静脉扩张和其他药理作用。
• Imidazoquinoxalinones, their aza analogs and process for their preparation
  申请人：BERLEX LABORATORIES, INC.

  公开号：EP0400583A1

  公开（公告）日：1990-12-05

  This invention relates to novel imidazoquinoxalinones and their aza analogs and to a process for their preparation. The compounds of this invention have been found to have inodilatory, vasodilatory, venodilatory and other pharmacologic effects.

  本发明涉及新型咪唑喹喔啉酮及其氮杂类似物，以及其制备工艺。已发现本发明的化合物具有扩张血管、扩张静脉和其他药理作用。
• AZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0721943A1

  公开（公告）日：1996-07-17

  An azole derivative represented by the following general formula (I) a salt thereof, a hydrate thereof or a solvate thereof. This compound has a function to inhibit steroid 17-20 lyase and is useful as preventive and treating agents for prostatic cancer, prostatic hypertrophy, virilism, breast cancer, mastopathy, histeromyoma, and endometriosis.

  由以下通式（I）代表的唑衍生物 其盐、水合物或溶液。 该化合物具有抑制类固醇 17-20 裂解酶的功能，可作为前列腺癌、前列腺肥大症、男性化 症、乳腺癌、乳腺增生症、子宫内膜异位症的预防和治疗药物。
• EP0429149A1
  申请人：——

  公开号：EP0429149A1

  公开（公告）日：1991-05-29