9-(4-butylphenyl)-N,N-dimethyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxamide | 920302-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-(4-butylphenyl)-N,N-dimethyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxamide
• CAS: 920302-36-9
• 化学式: C₂₉H₃₀N₂O
• 分子量: 422.57
• InChiKey: BSHFYZVXSDGEMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  36.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (4'-Butyl-biphenyl-3-yl)-hydrazine hydrochloride 、 N,N-dimethyl-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxamide 在 溶剂黄146 、 zinc(II) chloride 作用下， 生成 9-(4-butylphenyl)-N,N-dimethyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxamide
  参考文献：
  名称：

  Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor

  摘要：

  A novel series of benzo[a] carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. Starting from a 3.4 mu M high throughput screen hit, members of this series have been identified which are full agonists with functional potency < 50 nM and oral bioavailability in mice. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.068

文献信息

• HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS
  申请人：Alper Phillip B.

  公开号：US20090075996A1

  公开（公告）日：2009-03-19

  The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.

  该发明提供了一类新颖的化合物，包括含有这些化合物的药物组合物，以及使用这些化合物来治疗或预防与TPO活性异常或失调相关的疾病或障碍的方法，尤其是涉及血小板减少症的疾病或障碍。
• US8153671B2
  申请人：——

  公开号：US8153671B2

  公开（公告）日：2012-04-10