4'-Amino-4-hydroxy-2'-methylbiphenyl | 925909-08-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-Amino-4-hydroxy-2'-methylbiphenyl
• 英文别名: 4-(4-amino-2-methylphenyl)phenol
• CAS: 925909-08-6
• 化学式: C₁₃H₁₃NO
• 分子量: 199.252
• InChiKey: QTEULXFWUJXYPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4'-Amino-4-hydroxy-2'-methylbiphenyl 在 水 、 sodium hydride 、 三乙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 2,2-Dimethyl-3-[4-[2-methyl-4-(naphthalene-2-carbonylamino)phenyl]phenoxy]propanoic acid
  参考文献：
  名称：

  Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability

  摘要：

  A series of potent carboxylic acid DGAT1 inhibitors with high permeability were developed from a virtual screening hit. Strategies were employed to reduce Pgp substrate recognition and increase passive permeability, resulting in the discovery of a series showing good inhibition of cellular triglyceride synthesis. The mutagenic potential of prospective metabolites was evaluated in the Ames assay, and one aniline was shown to be devoid of mutagenicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.050
• 作为产物：
  描述：

  4-amino-2-methylphenylboronic acid 、 4-溴苯酚 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 caesium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 17.0h， 生成 4'-Amino-4-hydroxy-2'-methylbiphenyl
  参考文献：
  名称：

  Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability

  摘要：

  A series of potent carboxylic acid DGAT1 inhibitors with high permeability were developed from a virtual screening hit. Strategies were employed to reduce Pgp substrate recognition and increase passive permeability, resulting in the discovery of a series showing good inhibition of cellular triglyceride synthesis. The mutagenic potential of prospective metabolites was evaluated in the Ames assay, and one aniline was shown to be devoid of mutagenicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.050

文献信息

• SILICONE RUBBER
  申请人：EMPIRE TECHNOLOGY DEVELOPMENT LLC

  公开号：US20150203635A1

  公开（公告）日：2015-07-23

  Copolymers, as well as compounds, compositions, articles of manufacture, and methods of making thereof, are disclosed. The copolymers may generally exhibit flexibility properties and may generally have a high refractive index. The copolymers may generally be made by providing a dihydrodisiloxane and an aliphatic vinyl alcohol and combining the dihydrodisiloxane and the aliphatic vinyl alcohol under conditions that allow for hydrogenation of the aliphatic vinyl alcohol and result in coupling of the aliphatic vinyl alcohol to the dihydrodisiloxane to produce a hydroxyl substituted siloxane.

  本文介绍了共聚物、化合物、组合物、制造品以及制造方法。这些共聚物通常具有柔性特性和高折射率。通常可以通过提供二氢二硅氧烷和脂肪族乙烯醇，并在允许脂肪族乙烯醇氢化的条件下将二氢二硅氧烷和脂肪族乙烯醇结合起来，从而使脂肪族乙烯醇与二氢二硅氧烷偶联，产生羟基取代的硅氧烷来制备这些共聚物。
• Liquid-crystal polyester resin
  申请人：Ueno Ryuzo

  公开号：US20050054811A1

  公开（公告）日：2005-03-10

  The present invention provides a liquid-crystalline polyester resin which comprises monomer units derived from 2-hydroxy-3-naphthoic acid and/or 2-hydroxynaphthalene-3,6-dicarboxylic acid in an amount of 1-5000 mmol % based on the total monomer components of the resin and an alkaline metal compound in an amount of 10-3000 ppm as alkaline metal based on the total monomer components of the resin. The liquid-crystalline polyester resin of the present invention has good colorability, improved heat resistance and good mechanical properties.

  本发明提供了一种液晶聚酯树脂，其包含从2-羟基-3-萘甲酸和/或2-羟基萘并[3,6-二羧酸]衍生的单体单位，其数量为树脂总单体组分的1-5000 mmol％，以及一种碱性金属化合物，其数量为树脂总单体组分的10-3000 ppm作为碱性金属。本发明的液晶聚酯树脂具有良好的着色性，改善的耐热性和良好的机械性能。
• THERMOSETTING COMPOSITION AND PRINTED CIRCUIT BOARD USING THE SAME
  申请人：JUNG Myung Sup

  公开号：US20100124037A1

  公开（公告）日：2010-05-20

  A thermosetting composition including an organic solvent, a liquid crystalline thermoset oligomer, and either a crosslinking agent or an epoxy resin or both is disclosed. A printed circuit board which includes the thermosetting composition is also disclosed. The printed circuit board is produced by impregnating the thermosetting composition into a reinforcing material.

  本发明公开了一种热固性组合物，包括有机溶剂、液晶热固性低聚物，以及交联剂或环氧树脂或两者都有。本发明还公开了一种包括该热固性组合物的印刷电路板。该印刷电路板是通过将该热固性组合物浸渍到增强材料中制造的。
• THERMOPLASTIC RESIN WITH HIGH THERMAL CONDUCTIVITY
  申请人：Yoshihara Shusuke

  公开号：US20130035468A1

  公开（公告）日：2013-02-07

  Provided is a thermoplastic resin having excellent thermal conductivity, in which thermoplastic resin a change in number average molecular mass caused by progress of polymerization occurring when the thermoplastic resin material is melted and a change in thermal conductivity caused by the change in number average molecular mass are low. The thermoplastic resin has (A) a specific structure and (B) ends of molecular chains sealed by a monofunctional low molecular weight compound. The resin itself has excellent thermal conductivity. The change in number average molecular mass becomes small during melting of the thermoplastic resin material, so that the change in thermal conductivity of the resin itself becomes small.

  提供的是一种具有优异热导率的热塑性树脂，其中该热塑性树脂具有（A）特定结构和（B）由单官能低分子量化合物密封的分子链末端。当热塑性树脂材料熔化时，由聚合进展引起的数量平均分子量变化以及由数量平均分子量变化引起的热导率变化都很小。该树脂本身具有优异的热导率。在热塑性树脂材料熔化过程中，数量平均分子量的变化变得很小，因此树脂本身的热导率变化也很小。
• LIQUID-CRYSTAL POLYMER
  申请人：KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO

  公开号：EP1103573A1

  公开（公告）日：2001-05-30

  Provided is a liquid crystalline polymer which is obtained by copolymerizing at least one polyfunctional aromatic monomer selected from the group consisting of the compounds represented by the formulae (I), (II) and (III) below with at least one polymerizable monomer. The liquid crystalline polymer of the present invention is excellent in heat resistance, molding properties, flow properties and mechanical properties, especially it provide molded article with improved weld strength.

  本发明提供了一种液态结晶聚合物，它是由至少一种多官能芳香族单体与至少一种可聚合单体共聚而得，该单体选自由下式（I）、（II）和（III）所代表的化合物组成的组。本发明的液晶聚合物具有优异的耐热性、成型性能、流动性能和机械性能，特别是它能提高成型制品的焊接强度。