{5-Benzyloxycarbonylaminocarbonyl-3-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-3H-imidazol-4-yl}-carbamic acid benzyl ester | 170871-04-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物
• 英文名称: {5-Benzyloxycarbonylaminocarbonyl-3-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-3H-imidazol-4-yl}-carbamic acid benzyl ester
• 英文别名: benzyl N-[1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]-5-(phenylmethoxycarbonylamino)imidazole-4-carbonyl]carbamate
• CAS: 170871-04-2
• 化学式: C₃₇H₅₄N₄O₈Si₂
• 分子量: 739.029
• InChiKey: JKVIFNDWQWWSIF-FRXPANAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  51
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  {5-Benzyloxycarbonylaminocarbonyl-3-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-3H-imidazol-4-yl}-carbamic acid benzyl ester 在 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 、 吡啶 、 水 为溶剂， 反应 7.91h， 生成 (5-Benzyloxycarbonylaminocarbonyl-3-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-tetrahydro-furan-2-yl}-3H-imidazol-4-yl)-carbamic acid benzyl ester
  参考文献：
  名称：

  Oligodeoxynucleotides Embodying the Ambiguous Base Z, 5-Amino-imidazole-4-carboxamide

  摘要：

  Short oligomers containing 5-amino-1-(2-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide (dZ) were synthesized in solution using the phosphotriester methodology. Usual acyl groups were used for the canonical bases. For the exocyclic amino function of Z residue, the hydrogenolyzable benzyloxycarbonyl group was introduced

  DOI：

  10.1080/15257779508010683
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 吡啶 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 {5-Benzyloxycarbonylaminocarbonyl-3-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-3H-imidazol-4-yl}-carbamic acid benzyl ester
  参考文献：
  名称：

  Oligodeoxynucleotides Embodying the Ambiguous Base Z, 5-Amino-imidazole-4-carboxamide

  摘要：

  Short oligomers containing 5-amino-1-(2-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide (dZ) were synthesized in solution using the phosphotriester methodology. Usual acyl groups were used for the canonical bases. For the exocyclic amino function of Z residue, the hydrogenolyzable benzyloxycarbonyl group was introduced

  DOI：

  10.1080/15257779508010683