α-BROMO-4-DIMETHYLAMINO-2',3',4'-TRIMETHOXYCHALCONE | 127034-32-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: α-BROMO-4-DIMETHYLAMINO-2',3',4'-TRIMETHOXYCHALCONE
• 英文别名: 1-(2,3,4-trimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-bromoprop-2-en-1-one；(Z)-2-bromo-3-[4-(dimethylamino)phenyl]-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
• CAS: 127034-32-6
• 化学式: C₂₀H₂₂BrNO₄
• 分子量: 420.303
• InChiKey: ZTXFXMUEHWPLAM-VBKFSLOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (E)-4-(dimethylamino)-2′,3′,4′-trimethoxychalcone 在 溴 作用下， 以 四氯化碳 为溶剂， 生成 α-BROMO-4-DIMETHYLAMINO-2',3',4'-TRIMETHOXYCHALCONE
  参考文献：
  名称：

  Chalcones: a new class of antimitotic agents

  摘要：

  A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-pr open- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa cell test system. When evaluated in experimental tumor models in vivo, this compound exhibited antitumor activity against L1210 leukemia and B16 melanoma.

  DOI：

  10.1021/jm00169a021

文献信息

• Controlling the growth of certain tumor tissue with chalcone derivatives
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US04904697A1

  公开（公告）日：1990-02-27

  Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are therefore antimitotic agents which can be used to control the growth of tumor tissue and can be used as antigout agents.

  某些查尔酮衍生物据报道能够抑制微管蛋白聚合形成微管，因此是抗有丝分裂剂，可用于控制肿瘤组织的生长，也可用作抗痛风剂。
• Method of treating multiple sclerosis with chalcone derivatives
  申请人：Merrell Dow Pharmaceuticals, Inc.

  公开号：US04753965A1

  公开（公告）日：1988-06-28

  Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are therefore antimitotic agents which can be used to control the growth of tumor tissue and can be used as antigout agents.

  某些查尔酮衍生物据报道能够抑制微管蛋白聚合形成微管，因此是抗有丝分裂剂，可用于控制肿瘤组织的生长并可用作抗痛风剂。
• Novel use of compounds of the chalcones class
  申请人：——

  公开号：US20020143064A1

  公开（公告）日：2002-10-03

  Process for inhibiting vascularization of a tumor mass comprising administering, in an amount effective to inhibit vascularization, at least one chalcone of formula (I): 1 wherein: R is chosen from a hydrogen atom, a methyl group, an ethyl group, a chlorine atom, and a bromine atom, A is an NR 1 R 2 group, wherein R 1 and R 2 , which may be identical or different, are each chosen from a methyl group and an ethyl group, and n is an integer equal to 2 or 3.

  一种抑制肿瘤组织血管生成的处理过程，包括给予至少一种化合物，其有效抑制血管生成，该化合物为式（I）至少一种香豆素：1其中：R选自氢原子，甲基基团，乙基基团，氯原子和溴原子，A是NR1R2基团，其中R1和R2，可以相同也可以不同，分别选自甲基基团和乙基基团，n是等于2或3的整数。
• Methods of treating gout with chalcone derivatives
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US04863968A1

  公开（公告）日：1989-09-05

  Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are therefore antimitotic agents which can be used as antigout agents. The chalcone derivatives are also reported to inhibit the destruction of the myelin sheath in the central nervous system of multiple sclerosis patients and are thus useful in controlling the progressive nature of the disease.

  某些染料前体衍生物据报道能够抑制微管聚合形成微管，因此是抗有丝分裂剂，可用作抗痛风药物。这些染料前体衍生物据报道还能够抑制多发性硬化患者中枢神经系统髓鞘的破坏，因此对控制疾病的进展具有用处。
• STEMERICK, D. M.;SUNKARA, SAI P.;EDWARDS, M. L.
  作者：STEMERICK, D. M.、SUNKARA, SAI P.、EDWARDS, M. L.

  DOI：——

  日期：——