13,14,15,16-tetrahydroxestroquinol | 113830-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 13,14,15,16-tetrahydroxestroquinol
• 英文别名: 5,8-Dihydroxy-1-methyl-14-oxapentacyclo[11.6.1.02,11.04,9.016,20]icosa-2(11),3,9,13(20),15-pentaen-12-one
• CAS: 113830-95-8
• 化学式: C₂₀H₂₀O₄
• 分子量: 324.376
• InChiKey: YEQHKVXERJLAFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 13,14,15,16-tetrahydroxestroquinol 在 吡啶 作用下， 反应 3.0h， 生成 Acetic acid 8-acetoxy-12b-methyl-6-oxo-2,3,6,8,9,10,11,12b-octahydro-1H-5-oxa-benzo[k]acephenanthrylen-11-yl ester
  参考文献：
  名称：

  Xesto- and halenaquinone derivatives from a sponge, Adocia sp., from Truk lagoon

  摘要：

  DOI：

  10.1021/jo00252a007

文献信息

• Indoleamine 2,3-Dioxygenase (IDO) Inhibitors
  申请人：ANDERSEN Raymond J.

  公开号：US20090042868A1

  公开（公告）日：2009-02-12

  Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of the IDO-mediated tryptophan metabolic pathway. Such conditions may involve suppression of T-cell mediated immune response or may directly result from depletion of tryptophan or accumulation of a product of tryptophan degradation. Specific disease conditions include cataracts, age-related yellowing in the eye, neurodegenerative disorders, mood disorders, cancer and various bacterial/viral infections. IDO inhibitors of this invention are substituted naphthalene and anthracene diones. Novel compounds of this invention include the following taurine-substituted naphthaquinone structure.
• US7799776B2
  申请人：——

  公开号：US7799776B2

  公开（公告）日：2010-09-21
• Xesto- and halenaquinone derivatives from a sponge, Adocia sp., from Truk lagoon
  作者：Francis J. Schmitz、Stephen J. Bloor

  DOI：10.1021/jo00252a007

  日期：1988.8