7-氧代十一烷酸 | 71173-33-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 7-氧代十一烷酸
• 英文名称: 7-oxo-undecanoic acid
• 英文别名: 7-Oxo-undecansaeure；7-Oxoundecanoic acid
• CAS: 71173-33-6
• 化学式: C₁₁H₂₀O₃
• 分子量: 200.278
• InChiKey: HZIZHWOQKWVNFR-UHFFFAOYSA-N

物化性质

• 沸点：
  350.5±25.0 °C(Predicted)
• 密度：
  0.992±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918300090

反应信息

• 作为反应物：
  描述：

  7-氧代十一烷酸 在 palladium on activated charcoal 二苯基膦叠氮化物 、 氢气 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 49.67h， 生成 (R)-4-Carbamoyl-4-[(S)-2-(7-oxo-undecanoylamino)-propionylamino]-butyric acid
  参考文献：
  名称：

  The influence of the lipophilicity of 7-oxoacyl-l-alanyl-d-isoglutamines on their immunorestoration activity in vivo

  摘要：

  In search for immunologically active dipeptides, a series of new N-(7-oxoacyl)-L-alanyl-D-isoglutamines has been synthesized where lipophilicity was varied by changing the 7-oxoacyl residue from 7-oxooctanoyl to 7-oxotetradecanoyl. The immunological properties of the compounds were examined in an in vivo immunorestoration test. It was found that lipophilicity had a significant influence on the potency of the compounds tested. Compounds between N-(7-oxodecanoyl)-L-alanyl-D-isoglutamine and N-(7-oxotetradecanoyl)-L-alanyl-D-isoglutamine showed biphasic influence on efficacy. The most active compound found was 7-oxododecanoyl-L-alanyl-D-isoglutamine, which also has an activity comparable to that of azimexone.

  DOI：

  10.1016/s0223-5234(97)89858-3
• 作为产物：
  描述：

  1-n-butylcyclohept-1-ene 在 甲酸 、 臭氧 作用下， 生成 7-氧代十一烷酸
  参考文献：
  名称：

  OZONOLYSIS OF 1-SUBSTITUTED CYCLOOLEFINS

  摘要：

  通过向脂肪链中添加一个5、6或7个碳原子的环烯烃环，然后断开双键，可以扩展脂肪链。环的添加是通过烷基镁溴化物和环状酮之间的Grignard反应实现的，然后通过臭氧氧解打开产生的1-烷基环烯烃。最终产物是5、6或7-酮酸。

  DOI：

  10.1139/v55-211

文献信息

• SPIROCYCLIC COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
  申请人：Dhar T.G. Murali

  公开号：US20120202802A1

  公开（公告）日：2012-08-09

  The present application describes modulators of chemokine receptor activity of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.

  本申请描述了化学式(I)的趋化因子受体活性调节剂，或其立体异构体或药学上可接受的盐。此外，还公开了使用化学式(I)的调节剂治疗和预防炎症性疾病，如哮喘和过敏性疾病，以及自身免疫病理学，如类风湿性关节炎和移植排斥等的方法。
• The influence of the lipophilicity of 7-oxoacyl-l-alanyl-d-isoglutamines on their immunorestoration activity in vivo
  作者：M Sollner、S Pečar、A Štalc

  DOI：10.1016/s0223-5234(97)89858-3

  日期：1996.1

  In search for immunologically active dipeptides, a series of new N-(7-oxoacyl)-L-alanyl-D-isoglutamines has been synthesized where lipophilicity was varied by changing the 7-oxoacyl residue from 7-oxooctanoyl to 7-oxotetradecanoyl. The immunological properties of the compounds were examined in an in vivo immunorestoration test. It was found that lipophilicity had a significant influence on the potency of the compounds tested. Compounds between N-(7-oxodecanoyl)-L-alanyl-D-isoglutamine and N-(7-oxotetradecanoyl)-L-alanyl-D-isoglutamine showed biphasic influence on efficacy. The most active compound found was 7-oxododecanoyl-L-alanyl-D-isoglutamine, which also has an activity comparable to that of azimexone.
• OZONOLYSIS OF 1-SUBSTITUTED CYCLOOLEFINS
  作者：D. G. M. Diaper

  DOI：10.1139/v55-211

  日期：1955.11.1

  Extension of an aliphatic chain by five, six, or seven carbon atoms may be achieved by adding to it a 5-, 6-, or 7-membered olefmic alicycle and subsequently breaking the double bond. Addition of the ring is achieved by a Grignard reaction between an alkylmagnesium bromide and a cyclic ketone, and the resulting 1-alkylcycloolefin is opened by ozonolysis. The end product is a 5-, 6-, or 7-keto acid.

  通过向脂肪链中添加一个5、6或7个碳原子的环烯烃环，然后断开双键，可以扩展脂肪链。环的添加是通过烷基镁溴化物和环状酮之间的Grignard反应实现的，然后通过臭氧氧解打开产生的1-烷基环烯烃。最终产物是5、6或7-酮酸。