Azido-substituted fatty acid analogs which are useful in the fatty acid acylation of peptides and proteins and as antiviral agents are disclosed having the following chemical structure:
Z - (CH₂)xCOOR
wherein
Z = azido, tetrazolyl or triazolyl
R = H or C₁-C₈ alkyl, and
x = 8-12
or structure (I) as defined above and wherein a methylene group from carbon position 3 to within 2 carbons of Z is replaced with oxygen or sulfur.
已公开的
叠氮取代
脂肪酸类似物具有以下
化学结构,可用于肽和蛋白质的
脂肪酸酰化,也可用作抗病毒剂:
Z - (CH₂)xCOOR
其中
Z =
叠氮基、
四唑基或三唑基
R = H 或 C₁-C₈ 烷基,以及
x = 8-12
或如上定义的结构(I),其中 Z 的第 3 碳位至 2 碳位内的亚甲基被氧或
硫取代。