2,6-Dimethyl-thieno<3,2-b>thiophen | 31486-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并噻吩类
• 英文名称: 2,6-Dimethyl-thieno<3,2-b>thiophen
• 英文别名: 3,5-Dimethylthieno[3,2-b]thiophene
• CAS: 31486-84-7
• 化学式: C₈H₈S₂
• 分子量: 168.284
• InChiKey: NFQYPIYXZHAHKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-Dimethyl-thieno<3,2-b>thiophen 、 N-溴代丁二酰亚胺(NBS) 生成 5-Bromo-2,6-dimethylthieno[3,2-b]thiophene
  参考文献：
  名称：

  MARTELLI G.; TESTAFERRI L.; TIECCO M.; ZANIRATO P., J. ORG. CHEM. , 1975, 40, NO 23, 3384-3391

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(5-methylthiophen-3-yl)sulfanylpropan-2-one 、 三氯化铝 生成 2,6-Dimethyl-thieno<3,2-b>thiophen
  参考文献：
  名称：

  MARTELLI G.; TESTAFERRI L.; TIECCO M.; ZANIRATO P., J. ORG. CHEM. , 1975, 40, NO 23, 3384-3391

  摘要：

  DOI：

文献信息

• 5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS
  申请人：Dousson Cyril B.

  公开号：US20110150827A1

  公开（公告）日：2011-06-23

  Provided herein are 5,5-fused heteroarylene hepatitis C virus inhibitor compounds, for example, of Formula I, IA, or IB, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

  本文提供了5,5-融合的杂芳基丙型肝炎病毒抑制剂化合物，例如，化合物的结构式I、IA或IB，包含这些化合物的药物组合物，以及其制备方法。还提供了它们用于治疗宿主体内HCV感染的方法。
• METHODS FOR TREATING DRUG-RESISTANT HEPATITIS C VIRUS INFECTION WITH A 5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITOR
  申请人：Dousson Cyril B.

  公开号：US20120252721A1

  公开（公告）日：2012-10-04

  Provided herein are methods for treating or preventing drug-resistant hepatitis C virus infection in a subject, which comprises administering to the subject a 5,5-fused heteroarylene hepatitis C virus inhibitor compound, for example, of Formula I, IA, or IB.

  本文提供了一种治疗或预防受体内药物耐药性丙型肝炎病毒感染的方法，包括向受体内注射一种5,5-融合杂芳烃丙型肝炎病毒抑制剂化合物，例如，公式I、IA或IB中的化合物。
• FUSED THIOPHENES AND METHODS FOR MAKING AND USING SAME
  申请人：Corning Incorporated

  公开号：US20130281707A1

  公开（公告）日：2013-10-24

  Disclosed are compounds having one of the following formulae: wherein X is an aromatic nucleophilic substitution leaving group; R 1 is hydrogen, an alkyl group, or an aryl group; and Q 1 is a carboxyl protecting group or an aldehyde protecting group. Also disclosed are fused thiophenes that can be prepared using these compounds, as well as stannylthio-containing thiophene, thienothiophene, and dithienothiophene compounds that can be used to prepare fused thiophenes. Methods for making and using the aforementioned compounds, fused thiophenes, and stannylthio-containing thiophene, thienothiophene, and dithienothiophene compounds are also disclosed.

  本发明涉及具有以下公式之一的化合物：其中，X是芳香族亲核取代离子；R1是氢、烷基或芳基；Q1是羧酸保护基或醛保护基。本发明还涉及可使用这些化合物制备的融合噻吩，以及可用于制备融合噻吩的含锡硫基噻吩、噻吩噻吩和二噻吩噻吩化合物。本发明还涉及制备和使用上述化合物、融合噻吩和含锡硫基噻吩、噻吩噻吩和二噻吩噻吩化合物的方法。
• HEPATITIS C VIRUS INHIBITORS
  申请人：IDENIX PHARMACEUTICALS INC.

  公开号：US20160229866A1

  公开（公告）日：2016-08-11

  Provided herein are hepatitis C virus inhibitor compounds, for example, of any of Formulae I to XIV, Ilia to XlVa, Illb to XlVb, IIIc to XIVc, Hid to XlVd, Ille to XlVe, IA to IAe, IIA to IIAe, IB, IIB to IIBd, IIIB to IIIBd, IC to ICc, ID to IDd, and IE to lEc.pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for treating an HCV infection.

  本文提供了丙型肝炎病毒抑制剂化合物，例如，任何公式I至XIV，Ilia至XlVa，Illb至XlVb，IIIc至XIVc，Hid至XlVd，Ille至XlVe，IA至IAe，IIA至IIAe，IB，IIB至IIBd，IIIB至IIIBd，IC至ICc，ID至IDd和IE至IEc的化合物，以及包含这些化合物的制药组合物和其制备方法。还提供了使用这些化合物治疗HCV感染的方法。
• Organic semiconductor material and organic transistor using the same
  申请人：Li Jian

  公开号：US20080230776A1

  公开（公告）日：2008-09-25

  The invention relates to an organic semiconductor material with a high carrier mobility, which is capable of obtaining favorable semiconductor characteristics when used in an organic semiconductor device, and an organic transistor using the same. More specifically, the present invention has a following structure including an oligothiophene part and a connecting part G; where, R 1 and R 2 are a hydrogen, a alkyl group, an alkoxy group, an aryl group, or an alkenyl group, R 1 and R 2 may be identical or different from each other, and where n is an integer. In the organic semiconductor material, the structure of the connecting part G may be any of the following: where, R 3 and R 4 are a hydrogen, an alkyl group, an alkoxy group, an aryl group, or a alkenyl group, R 3 and R 4 may be identical or different from each other, and where n is an integer of 1 to 3.