4-methyl-3-phenylpyridazine | 68206-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-methyl-3-phenylpyridazine
• 英文别名: 4-Methyl-3-phenyl-piperazin；Methylphenylpyridazin
• CAS: 68206-21-3
• 化学式: C₁₁H₁₀N₂
• 分子量: 170.214
• InChiKey: OOOZDVOOTJDGQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methyl-3-phenylpyridazine 在 间氯过氧苯甲酸 、 硫酸二甲酯 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Pyridazine N-Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles

  摘要：

  Pyridazine N-oxides are used for the first time as precursors of metallocarbenes. These nitrogen-rich heterocycles led to the discovery of a novel acceptor and donor-acceptor enalcarbenoids. The synthetic utility of these metallocarbenes was demonstrated in the rhodium-catalyzed denitrogenative transannulation of pyridazine N-oxides with pyrroles to the valuable alkyl, 7-aryl, and 7-styryl indoles. The transannulation strategy was applied to the synthesis of a potent anticancer agent.

  DOI：

  10.1021/acs.orglett.5b03064
• 作为产物：
  描述：

  6-氯-4-甲基-3-苯基-吡嗪 在 palladium 10% on activated carbon 、 氢气 、 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以70%的产率得到4-methyl-3-phenylpyridazine
  参考文献：
  名称：

  Pyridazine N-Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles

  摘要：

  Pyridazine N-oxides are used for the first time as precursors of metallocarbenes. These nitrogen-rich heterocycles led to the discovery of a novel acceptor and donor-acceptor enalcarbenoids. The synthetic utility of these metallocarbenes was demonstrated in the rhodium-catalyzed denitrogenative transannulation of pyridazine N-oxides with pyrroles to the valuable alkyl, 7-aryl, and 7-styryl indoles. The transannulation strategy was applied to the synthesis of a potent anticancer agent.

  DOI：

  10.1021/acs.orglett.5b03064

文献信息

• [EN] ANTI-INFLAMMATORY AND PROTEIN KINASE INHIBITOR COMPOSITION AND METHOD OF USE<br/>[FR] COMPOSITION ANTI-INFLAMMATOIRE ET INHIBITRICE DE LA PROTEINE KINASE ET METHODE D'UTILISATION
  申请人：UNIV NORTHWESTERN

  公开号：WO2003018563A1

  公开（公告）日：2003-03-06

  A novel class of pyridazine compositions and related methods of use.

  一种新型的吡啶嗪组合物及其相关使用方法。
• Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors
  申请人：Université Louis Pasteur

  公开号：EP2264014A1

  公开（公告）日：2010-12-22

  This invention relates to a novel class of pyridazine compounds and related methods of use.

  本发明涉及一类新型哒嗪化合物及相关使用方法。
• Organic electroluminescence device
  申请人：UDC Ireland

  公开号：US10454042B2

  公开（公告）日：2019-10-22

  An object of the present invention is to provide an organic electroluminescence device having excellent light emission efficiency and durability, in particular, durability when driving at a high temperature. Provided is an organic electroluminescence device including on a substrate a pair of electrodes, and at least one layer of an organic layer including a light emitting layer containing a light emitting material disposed between the electrodes, wherein the light emitting layer includes at least each one of specific indolocarbazole derivatives and specific condensed ring metal complexes.

  本发明的目的是提供一种有机电致发光器件，该器件具有优异的发光效率和耐用性，特别是在高温驱动时的耐用性。本发明提供了一种有机电致发光器件，包括在基底上的一对电极，以及至少一层有机层，该有机层包括设置在电极之间的包含发光材料的发光层，其中发光层包括特定吲哚咔唑衍生物和特定缩合环金属配合物中的至少一种。
• Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
  申请人：——

  公开号：US20030176437A1

  公开（公告）日：2003-09-18

  A novel class of pyridazine compositions and related methods of use.

  一类新型哒嗪组合物及相关使用方法。
• ANTI-INFLAMMATORY AND PROTEIN KINASE INHIBITOR COMPOSITION AND METHOD OF USE
  申请人：NORTHWESTERN UNIVERSITY

  公开号：EP1430033A1

  公开（公告）日：2004-06-23