N-tert-butoxycarbonyl-propargylglycine ethyl ester | 245061-00-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tert-butoxycarbonyl-propargylglycine ethyl ester
• 英文别名: ethyl 2-[(tert-butoxycarbonyl)amino]pent-4-ynoate；4-Pentynoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester；ethyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]pent-4-ynoate
• CAS: 245061-00-1
• 化学式: C₁₂H₁₉NO₄
• 分子量: 241.287
• InChiKey: HMMGSHTTWMZUPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-tert-butoxycarbonyl-propargylglycine ethyl ester 在 sodium hydroxide 作用下， 以 水 为溶剂， 以90%的产率得到2-(叔丁氧基羰基)-4-戊炔酸
  参考文献：
  名称：

  An uncatalyzed cyclo-elimination process for the release ofN3-alkylated hydantoins from solid-phase: synthesis of novel isoxazoloimidazolidinediones

  摘要：

  Solid-phase regioselective nitrile oxide 1,3-dipolar cycloaddition to an omega-alkynyl ester followed by reductive alpha-N-alkylation and isocyanate alpha-N-acylation delivers I and sets the stage for the uncatalyzed carbanilide cycloelimination of isoxazoloimidazolidinedione heterocycles (I --> II). This traceless release step is induced by simply warming the urea ester intermediate, but requires that the N3 of the nascent hydantoin be fully substituted (I --> II; R(c)not equal H). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01145-4
• 作为产物：
  描述：

  ethyl 2-[(diphenylmethylidene)amino]pent-4-ynoate 在 盐酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.08h， 生成 N-tert-butoxycarbonyl-propargylglycine ethyl ester
  参考文献：
  名称：

  Solid-Phase Synthesis of Novel Heterocycles Containing Thiohydantoin and Isoxazole Rings

  摘要：

  DOI：

  10.1021/jo991166p

文献信息

• Diaryl Ethers Using Fischer Chromium Carbene Mediated Benzannulation
  作者：Shon R. Pulley、Subhabrata Sen、Andrei Vorogushin、Erika Swanson

  DOI：10.1021/ol990949u

  日期：1999.12.1

  synthetic challenge of compounds containing the diaryl ether linkage encourages the development of new methodologies targeted toward this structural subunit. The syntheses of diaryl ethers 2 using a benzannulation strategy that formally involves a [3 + 2 + 1] cycloaddition between aryloxy-substituted Fischer carbenes 1 and alkynes are described. This methodology provides a neutral near ambient temperature formation

  含二芳基醚键的化合物的生物学相关性和不可抗拒的合成挑战鼓励开发针对该结构亚基的新方法。描述了使用苯环化策略合成二芳基醚2的方法，该策略正式涉及芳氧基取代的Fischer卡宾1与炔烃之间的[3 + 2 + 1]环加成。该方法提供了在环境温度附近形成中性的二芳基醚的方法。
• A Very Simple Synthesis of 1-(Ethyl 6-<i>O</i>-Acetyl-2,3,4-trideoxy-α-d-<i>erythro</i>-hex-2-enopyranos-4-yl)-1,2,3-triazole Derivatives
  作者：Denis Sinou、Rajendra M. Srivastava、Ronaldo N. de Oliveira

  DOI：10.1055/s-2006-926280

  日期：——

  The copper-catalyzed reaction of ethyl 4-azido-6-O-acetoxy-2,3,4-trideoxy-α-d-erythro-hex-2-enopyranoside with various functionalized alkynes gave the corresponding 1-(ethyl 6-O-acetyl-2,3,4-trideoxy-α-d-erythro-hex-2-enopyranos-4-yl)-1,2,3-triazole derivatives in quite good yields, which could be transformed into (ethyl 2,3,6-tri-O-acetyl-4-deoxy-α-d-mannopyranosyl)-1H-1,2,3-triazole by a simple bis-hydroxylation.

  在铜催化下，4-叠氮-6-O-乙酰氧基-2,3,4-三脱氧-δ±-d-赤式-己-2-烯吡喃糖苷乙酯与各种官能化炔类化合物发生反应，得到了相应的 1-（6-O-乙酰基-2,3,4-三脱氧-δ±-d-赤式-己-2-烯吡喃糖苷-4-基）-1,2,3-三唑衍生物、这些衍生物可通过简单的双羟基化反应转化为（乙基 2,3,6-O-三乙酰基-4-脱氧δ±-d-吡喃甘露糖基）-1H-1,2,3-三唑。
• Polynitrogen compounds and uses thereof as fluorescent chromophores
  申请人：UNIVERSITE D'ORLEANS

  公开号：US10954436B2

  公开（公告）日：2021-03-23

  The present invention relates to the use, as a fluorescent chromophore, of a compound with formula (I) wherein: A1 is —N— or —C(Y1)—; A2 is —N— or —C(Y2)—; A3 is —N— or —C(Y3)—; A4 is —N— or —C(Y4)—; at least one of A1, A2, A3 and A4 representing —N—; X1 is —N— or —C(Y5)—; X2 is —N— or —C(Y6)—; X3 is —N— or —C(Y7)—; and Y1, Y2, Y3, Y4, Y5, Y6 and Y7 are in particular chosen independently of one another from the group made up of: H, electron-donor groups and electron-attracting groups.

  本发明涉及一种式（I）化合物作为荧光发色团的用途，其中：A1 是-N-或-C(Y1)-； A2 是-N-或-C(Y2)-； A3 是-N-或-C(Y3)-； A4 是-N-或-C(Y4)-； A1、A2、A3 和 A4 中至少有一个代表-N-；X1 是-N-或-C(Y5)-； X2 是-N-或-C(Y6)-； X3 是-N-或-C(Y7)-； Y1、Y2、Y3、Y4、Y5、Y6 和 Y7 尤其可以彼此独立地从由以下各项组成的组中选择：H、电子供体基团和电子吸引基团。
• COMPOSES POLYAZOTES ET LEURS UTILISATIONS COMME CHROMOPHORES FLUORESCENTS
  申请人：Universite D'Orleans

  公开号：EP3325486A1

  公开（公告）日：2018-05-30
• POLYNITROGEN COMPOUNDS AND USES THEREOF AS FLUORESCENT CHROMOPHORES
  申请人：UNIVERSITE D'ORLEANS

  公开号：US20180194997A1

  公开（公告）日：2018-07-12

  The present invention relates to the use, as a fluorescent chromophore, of a compound with formula (I) wherein: A 1 is —N— or —C(Y 1 )—; A 2 is —N— or —C(Y 2 )—; A 3 is —N— or —C(Y 3 )—; A 4 is —N— or —C(Y 4 )—; at least one of A 1 , A 2 , A 3 and A 4 representing —N—; X 1 is —N— or —C(Y 5 )—; X 2 is —N— or —C(Y 6 )—; X 3 is —N— or —C(Y 7 )—; and Y 1 , Y 2 , Y 3 , Y 4 , Y 5 , Y 6 and Y 7 are in particular chosen independently of one another from the group made up of: H, electron-donor groups and electron-attracting groups.