1-O-Hexadecyl-3-O-methylglycerol | 93177-66-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-O-Hexadecyl-3-O-methylglycerol
• 英文别名: 1-Hexadecyloxy-3-methoxy-2-propanol；1-Hexadecoxy-3-methoxypropan-2-ol
• CAS: 93177-66-3
• 化学式: C₂₀H₄₂O₃
• 分子量: 330.552
• InChiKey: JDRWKGMBGLGSRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  23
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Bromethyl-phosphorsaeuredichlorid 、 1-O-Hexadecyl-3-O-methylglycerol 、 三甲胺 生成 1-O-Hexadecyl-3-O-methylglycero-2-phosphocholin
  参考文献：
  名称：

  Kertscher, Heinz-Peter; Gawrisch, Klaus; Ostermann, Gunter, Zeitschrift für Chemie, 1986, vol. 26, # 5, p. 167

  摘要：

  DOI：
• 作为产物：
  描述：

  2-benzyloxy-3-hexadecyloxy-1-propanol 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 1-O-Hexadecyl-3-O-methylglycerol
  参考文献：
  名称：

  Kertscher, Heinz-Peter; Gawrisch, Klaus; Ostermann, Gunter, Zeitschrift für Chemie, 1986, vol. 26, # 5, p. 167

  摘要：

  DOI：

文献信息

• Hair growers
  申请人：——

  公开号：US20030198614A1

  公开（公告）日：2003-10-23

  The present invention provides a hair growth promoting composition having an excellent hair growth promoting effect. The hair promoting composition comprises, as an effective ingredient, a composition expressed by following Formula (I): 1 wherein one of R 1 to R 4 is selected from a group of C 14-22 alkyl, C 14-22 alkoxy and C 14-22 acyloxy groups, and the others are selected from a group of H, OH, C 1-3 alkyl and C 1-3 alkoxy groups; and when R 1 is C 14-22 alkoxy group and one of R 2 and R 4 is C 1-3 alkoxy group, R 3 is H, C 1-3 alkyl or C 1-3 alkoxy group; and when R 1 is C 14-22 acyloxy group, at least one of R 2 to R 4 is C 1-3 alkoxy group.

  本发明提供了一种具有优异的促进头发生长效果的促进头发生长的组合物。该促进头发生长的组合物包括以下式（I）所表示的组合物作为有效成分：其中R1至R4中的一个选择自C14-22烷基，C14-22烷氧基和C14-22酰氧基的一组，而其他的选择自H，OH，C1-3烷基和C1-3烷氧基的一组；当R1为C14-22烷氧基且R2和R4中的一个为C1-3烷氧基时，R3为H，C1-3烷基或C1-3烷氧基；当R1为C14-22酰氧基时，R2至R4中至少有一个为C1-3烷氧基。
• PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS
  申请人：Halperin Gideon

  公开号：US20120130108A1

  公开（公告）日：2012-05-24

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

  本发明揭示了一种新型合成路线，适用于工业制备治疗有益的氧化磷脂。特别是，揭示了一种高效制备具有甘油骨架和一个或多个氧化物附着在甘油骨架上的化合物的新方法，这些方法不需要柱层析。此外，还揭示了一种引入含磷基团（如磷酸盐基团）到具有甘油骨架的化合物和由此形成的中间体的新方法。
• Process for the Preparation of Oxidized Phospholipids
  申请人：Vascular Biogenics Ltd.

  公开号：US20130158283A1

  公开（公告）日：2013-06-20

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

  揭示了一种新的合成路线，适用于工业制备具有治疗效果的氧化磷脂类化合物。特别是，揭示了一种高效制备具有甘油骨架和一个或多个氧化基团附着在甘油骨架上的化合物的新方法，这些方法不需要使用柱层析法。此外，还揭示了一种引入含磷基团（如磷酸盐基团）到具有甘油骨架的化合物和由此形成的中间体的新方法。
• High-Purity Phospholipids
  申请人：HALPERIN Gideon

  公开号：US20130079540A1

  公开（公告）日：2013-03-28

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4′-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).

  本发明揭示了一种新的合成路线，非常适用于工业制备治疗上有益的氧化磷脂。特别地，本发明揭示了一种高效制备具有甘油骨架和一个或多个氧化基团附着在甘油骨架上的化合物的新方法，这些方法不需要柱层析。进一步揭示了一种引入含磷基团（如磷酸盐基团）到具有甘油骨架和由此形成的中间体的新方法。进一步揭示了几乎纯的1-十六烷基-2-(4'-羧基)丁基-sn-甘油-3-磷酸胆碱（CI-201）。
• HAIR GROWERS
  申请人：Shiseido Co., Ltd.

  公开号：EP1314417A1

  公开（公告）日：2003-05-28

  The present invention provides a hair growth promoting composition having an excellent hair growth promoting effect. The hair promoting composition comprises, as an effective ingredient, a composition expressed by following Formula (I): wherein one of R1 to R4 is selected from a group of C14-22 alkyl, C14-22 alkoxy and C14-22 acyloxy groups, and the others are selected from a group of H, OH, C1-3 alkyl and C1-3 alkoxy groups; and when R1 is C14-22 alkoxy group and one of R2 and R4 is C1-3 alkoxy group, R3 is H, C1-3 alkyl or C1-3 alkoxy group; and when R1 is C14-22 acyloxy group, at least one of R2 to R4 is C1-3 alkoxy group.

  本发明提供了一种具有极佳生发效果的生发组合物。该生发组合物包括作为有效成分的由下式（I）表示的组合物： 其中 R1 至 R4 中的一个选自 C14-22 烷基、C14-22 烷氧基和 C14-22 乙酰氧基，其它选自 H、OH、C1-3 烷基和 C1-3 烷氧基；当 R1 为 C14-22 烷氧基且 R2 和 R4 中的一个为 C1-3 烷氧基时，R3 为 H、C1-3 烷基或 C1-3 烷氧基；当 R1 为 C14-22 乙酰氧基时，R2 至 R4 中至少有一个为 C1-3 烷氧基。