·4-amino-1-(4-sulfophenyl)-2,3-dimethyl-5-pyrazolone | 1061212-74-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ·4-amino-1-(4-sulfophenyl)-2,3-dimethyl-5-pyrazolone
• 英文别名: 4-amino-1-(4-sulfophenyl)-2,3-dimethyl-5-pyrazolone；4-(4-Amino-2,3-dimethyl-5-oxopyrazol-1-yl)benzenesulfonic acid
• CAS: 1061212-74-5
• 化学式: C₁₁H₁₃N₃O₄S
• 分子量: 283.308
• InChiKey: SLNZRCHBLKKXOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(2,3-dimethyl-5-oxo-2,5-dihydro-pyrazol-1-yl)-benzenesulfonic acid 在 盐酸 、 sodium nitrite 、 锌 作用下， 以 水 为溶剂， 反应 0.19h， 生成 ·4-amino-1-(4-sulfophenyl)-2,3-dimethyl-5-pyrazolone
  参考文献：
  名称：

  OXIDATIVE COLOR-DEVELOPING COMPOUNDS, SALTS THEREOF, PROCESS FOR PRODUCTION OF THE SAME, REAGENT COMPOSITIONS AND TEST TOOLS MADE BY USING THE SAME

  摘要：

  公开号：

  EP2138483B1

文献信息

• OXIDATIVE CHROMOGENIC COMPOUND OR SALT THEREOF AND PRODUCTION METHOD THEREOF, AND REAGENT COMPOSITION AND TEST INSTRUMENT USING THE SAME
  申请人：Kawanishi Tetsuro

  公开号：US20100062464A1

  公开（公告）日：2010-03-11

  It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the following chemical formula (1): wherein R 1 and R 2 are each independently a linear or branched alkyl group having 1 to 5 carbon atoms; R 3 , R 4 , R 5 , R 6 and R 7 are each independently a hydrogen atom, a carboxyl group or a sulfonic acid group, or salt thereof, provided that at least one of R 3 to R 7 is a carboxyl group or a sulfonic acid group, or salt thereof, and the others are hydrogen atoms, and the production method thereof, and the reagent composition and test instrument using the same.

  本发明的目的是提供一种快速、高精度和高灵敏度测量各种成分浓度的手段。本发明提供了一种氧化性显色化合物或其盐，其化学式如下（1）：其中R1和R2分别是具有1至5个碳原子的线性或支链烷基；R3、R4、R5、R6和R7分别是氢原子、羧基或磺酸基，或其盐，但至少其中之一是羧基或磺酸基，或其盐，其余为氢原子，以及其生产方法、试剂组成和使用该试剂组成的测试仪器。
• COMPONENT MEASUREMENT DEVICE, COMPONENT MEASUREMENT METHOD, AND COMPONENT MEASUREMENT PROGRAM
  申请人：Terumo Kabushiki Kaisha

  公开号：EP3428623A1

  公开（公告）日：2019-01-16

  A component measurement device according to the present invention is for measuring a component of interest in blood based on an optical property of a mixture containing a pigmentary component colored by a color reaction between the component of interest in the blood and a reagent, and the component measurement device is configured to correct a measured value of absorbance of the mixture at a measuring wavelength based on information on scattered light and a ratio between reduced hemoglobin and oxygenated hemoglobin in erythrocytes.

  根据本发明，一种成分测量装置用于根据含有色素成分的混合物的光学特性测量血液中的相关成分，该色素成分是通过血液中的相关成分与试剂之间的颜色反应而着色的，成分测量装置被配置为根据散射光信息和红细胞中还原血红蛋白与氧合血红蛋白之间的比率，修正混合物在测量波长处的吸光度测量值。
• COMPONENT MEASUREMENT DEVICE AND COMPONENT MEASUREMENT DEVICE SET
  申请人：Terumo Kabushiki Kaisha

  公开号：EP3605069A1

  公开（公告）日：2020-02-05

  Provided is a component measurement device and a component measurement device set, which are so configured that measurement accuracy is unlikely reduced even if a plurality of light sources is used. A component measurement device according to the present disclosure is a component measurement device for measuring a component of interest in blood on the basis of optical characteristics of a mixture containing a color component produced by a color reaction between the component of interest in the blood and a reagent, the component measurement device including: a first light source configured to emit irradiation light of a first predetermined wavelength to be emitted to the mixture; and a second light source configured to emit irradiation light of a second predetermined wavelength to be emitted to the mixture and to be used for estimation of a noise amount contained in a measured value of absorbance of the mixture measured by using the irradiation light of the first light source, the noise amount being derived other than from the color component, in which the first light source and the second light source are aligned in a flow path width direction perpendicular to a flow direction of the blood at a position where the mixture is present in a flow path of the blood.

  本发明提供了一种成分测量装置和一套成分测量装置，即使使用多个光源也不会降低测量精度。根据本公开的成分测量装置是一种成分测量装置，用于根据混合物的光学特性测量血液中的相关成分，混合物中含有由血液中的相关成分和试剂之间的颜色反应产生的颜色成分，成分测量装置包括：第一光源，配置为向混合物发射第一预定波长的照射光；第二光源，配置为发射第二预定波长的辐照光到混合物中，并用于估计通过使用第一光源的辐照光测量的混合物吸光度测量值中包含的噪声量，噪声量不是来自颜色成分，其中第一光源和第二光源在混合物存在于血液流路中的位置，在垂直于血液流路方向的流路宽度方向上排列。
• Component measurement device, component measurement method, and component measurement program
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：US11320382B2

  公开（公告）日：2022-05-03

  A component measurement device for measuring a component of interest in blood based on an optical property of a mixture containing a pigmentary component colored by a color reaction between the component of interest in the blood and a reagent, the component measurement device including: an absorbance obtaining unit configured to obtain a measured value of absorbance of the mixture at a measuring wavelength; and an absorbance correction unit configured to correct the measured value of absorbance of the mixture at the measuring wavelength based on information on scattered light and a ratio between reduced hemoglobin and oxygenated hemoglobin in erythrocytes.

  一种成分测量装置，用于根据含有色素成分的混合物的光学特性测量血液中的相关成分，该色素成分是通过血液中的相关成分与试剂之间的颜色反应而着色的，该成分测量装置包括：吸光度获取单元，配置用于获取混合物在测量波长处的吸光度测量值；以及吸光度校正单元，配置用于根据散射光信息和红细胞中还原血红蛋白与氧合血红蛋白之间的比率校正混合物在测量波长处的吸光度测量值。
• COMPONENT MEASUREMENT APPARATUS, COMPONENT MEASUREMENT APPARATUS SET, AND INFORMATION PROCESSING METHOD
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：US20220390380A1

  公开（公告）日：2022-12-08

  A component measurement apparatus includes: a chip insertion space for inserting a component measurement chip provided with a reagent that reacts with a component to be measured in a sample; a light emitting unit configured to emit radiation light to the component measurement chip in a state in which the component measurement chip is inserted into the chip insertion space; a light receiving unit configured to receive light transmitted through or reflected from the component measurement chip; and a control unit configured to determine whether there is a possibility that an incorrect processing mode has been selected for execution.