Dimethyl 2-methylidene-3-[8-[2-[(2-methylpropan-2-yl)oxycarbonyl]hydrazinyl]-8-oxooctyl]butanedioate | 1046480-11-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Dimethyl 2-methylidene-3-[8-[2-[(2-methylpropan-2-yl)oxycarbonyl]hydrazinyl]-8-oxooctyl]butanedioate
• CAS: 1046480-11-8
• 化学式: C₂₀H₃₄N₂O₇
• 分子量: 414.499
• InChiKey: AWTOLBHOOIPCLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Dimethyl 2-methylidene-3-[8-[2-[(2-methylpropan-2-yl)oxycarbonyl]hydrazinyl]-8-oxooctyl]butanedioate 在 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 2-Methylidene-3-[8-[2-[(2-methylpropan-2-yl)oxycarbonyl]hydrazinyl]-8-oxooctyl]butanedioic acid
  参考文献：
  名称：

  Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B

  摘要：

  The first, concise total synthesis of (+/-)-tensyuic acids B, C, and E, using chemoselective formal S(N)2' type Grignard reactions and selective esterification, is described. In addition, the optical purity of natural (+/-)tensyuic acid B was determined using Chirabite-AR. Synthetic tensyuic acids, together with their intermediate compounds, were found to possess useful bioactive properties, with some of them showing potent activity against Trypanosorna brucei brucei strain GUTat 3.1. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.035
• 作为产物：
  描述：

  肼基甲酸叔丁酯 、 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以315 mg的产率得到Dimethyl 2-methylidene-3-[8-[2-[(2-methylpropan-2-yl)oxycarbonyl]hydrazinyl]-8-oxooctyl]butanedioate
  参考文献：
  名称：

  Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B

  摘要：

  The first, concise total synthesis of (+/-)-tensyuic acids B, C, and E, using chemoselective formal S(N)2' type Grignard reactions and selective esterification, is described. In addition, the optical purity of natural (+/-)tensyuic acid B was determined using Chirabite-AR. Synthetic tensyuic acids, together with their intermediate compounds, were found to possess useful bioactive properties, with some of them showing potent activity against Trypanosorna brucei brucei strain GUTat 3.1. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.035