cis-2-(N-BOC-aminomethyl)-cyclopropanemethanol | 1360603-30-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-2-(N-BOC-aminomethyl)-cyclopropanemethanol
• 英文别名: tert-butyl N-[[2-(hydroxymethyl)cyclopropyl]methyl]carbamate
• CAS: 1360603-30-0
• 化学式: C₁₀H₁₉NO₃
• 分子量: 201.266
• InChiKey: KXNPTSIIVCAMOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-2-(N-BOC-aminomethyl)-cyclopropanemethanol 在 4-二甲氨基吡啶 、 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.0h， 生成 tert-butyl ((2-((3-cyclopropyl-4-(5-fluoro-6-methylpyridin-2-yl)-1H-pyrazol-1-yl)methyl)cyclopropyl)methyl)carbamate
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF TREATING CANCERS
  [FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE CANCERS

  摘要：

  This disclosure relates to GSPT1 degrader compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds or salts, and methods of making and using the compounds or salts for the treatment of certain diseases. The disclosure also relates to methods for identifying such compounds.

  公开号：

  WO2023193760A1
• 作为产物：
  描述：

  ethyl 2-(((tert-butoxycarbonyl)amino)methyl)cyclopropane-1-carboxylate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 cis-2-(N-BOC-aminomethyl)-cyclopropanemethanol
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF TREATING CANCERS
  [FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE CANCERS

  摘要：

  This disclosure relates to GSPT1 degrader compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds or salts, and methods of making and using the compounds or salts for the treatment of certain diseases. The disclosure also relates to methods for identifying such compounds.

  公开号：

  WO2023193760A1

文献信息

• Ornithine decarboxylase inhibiting cyclic aminooxy compounds
  申请人：Ciba-Geigy Corporation

  公开号：US05516806A1

  公开（公告）日：1996-05-14

  Compounds of formula (I): H.sub.2 N--(CH.sub.2).sub.n --A--(CH.sub.2).sub.m --O--NH.sub.2 and salts thereof are described in which the radical A is C.sub.3 -C.sub.6 cycloalkylene; n is 0 or 1 and, independently thereof, m is 0 or 1; with the provisos that a) the distance between the aminooxy radical H.sub.2 N--O-- and the amino group --NH.sub.2 is at least 3 and not more than 4 carbon atoms and that b) the two radicals H.sub.2 N--(CH.sub.2).sub.n -- and --(CH.sub.2).sub.m --O--NH.sub.2 are not bonded to the same ring carbon of A. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.

  化合物的结构式（I）：H.sub.2 N--(CH.sub.2).sub.n --A--(CH.sub.2).sub.m --O--NH.sub.2及其盐被描述，其中基团A为C.sub.3 -C.sub.6环烷基；n为0或1，独立地，m为0或1；具体规定为a）氨氧基H.sub.2 N--O--与氨基--NH.sub.2之间的距离至少为3个碳原子，但不超过4个碳原子；b）两个基团H.sub.2 N--(CH.sub.2).sub.n --和--(CH.sub.2).sub.m --O--NH.sub.2不与A的同一环碳原子相结合。结构式（I）的化合物及其盐是鸟氨酸脱羧酶抑制剂。
• ORNITHINE DECARBOXYLASE INHIBITING CYCLIC AMINOOXY COMPOUNDS
  申请人：CIBA-GEIGY AG

  公开号：EP0644872A1

  公开（公告）日：1995-03-29
• DOPAMINE-B-HYDROXYLASE INHIBITORS
  申请人：BIAL - PORTELA & Cª, S.A.

  公开号：US20210171528A1

  公开（公告）日：2021-06-10

  This invention relates to: (a) compounds of formula Ia (with R1, R4 to R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions (comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
• US5516806A
  申请人：——

  公开号：US5516806A

  公开（公告）日：1996-05-14
• [EN] ORNITHINE DECARBOXYLASE INHIBITING CYCLIC AMINOOXY COMPOUNDS<br/>[FR] COMPOSES AMINOOXY CYCLIQUES INHIBITEURS DE LA DECARBOXYLASE D'ORNITHINE
  申请人：CIBA-GEIGY AG

  公开号：WO1994024093A1

  公开（公告）日：1994-10-27

  (EN) Compounds of the formula (I): H2N-(CH2)n-A-(CH2)m-O-NH2 and salts thereof are described in which the radical A is C3-C6cycloalkylene; n is 0 or 1 and, independently thereof, m is 0 or 1; with the provisos that a) the distance between the aminooxy radical H2N-O- and the amino group -NH2 is at least 3 and not more than 4 carbon atoms and that b) the two radicals H2N-(CH2)n- and -(CH2)m-O-NH2 are not bonded to the same ring carbon atom of A. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.(FR) L'invention concerne des composés de la formule (I) et leurs sels. Dans ladite formule le radical A représente cycloalkylène C3-C6; n vaut 0 ou 1 et indépendamment de n, m vaut 0 ou 1, avec les conditions que a) la distance entre le radical aminooxy H2N-O- et le groupe amino-NH2- soit au moins de 3 mais pas supérieure à 4 atomes de carbone et que b) les deux radicaux H2N-(CH2)n et -(CH2)m -O-NH2 ne soient pas liés au même atome de carbone de A. Les composés de formule (I) et leurs sels sont des inhibiteurs de la décarboxylase d'ornithine.