5,6-Dihydroxy-skatol | 4813-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5,6-Dihydroxy-skatol
• 英文别名: 5,6-dihydroxy-3-methyl indole；3-methyl-indole-5,6-diol；3-Methyl-indol-5,6-diol；3-methyl,5,6-dihydroxyindole；3-Methyl-1H-indole-5,6-diol
• CAS: 4813-45-0
• 化学式: C₉H₉NO₂
• 分子量: 163.176
• InChiKey: ZUTZCXDHPIACCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  56.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,6-Dihydroxy-skatol 在 N,O-双三甲硅基乙酰胺 作用下， 以78%的产率得到5,6-bis(trimethylsilyloxy)-3-methylindole
  参考文献：
  名称：

  Dyeing compositions for keratinous fibres based on indole derivatives,

  摘要：

  基于吲哚衍生物的角蛋白纤维染料组合物及新化合物。用于角蛋白纤维，尤其是人类头发的染料组合物，其特征在于它含有至少一种符合以下公式的染料，其中R.sub.1表示氢原子或较低的烷基基团或基团--SiR.sub.9 R.sub.10 R.sub.11；R.sub.2和R.sub.3，可以相同也可以不同，表示氢原子，较低的烷基基团，羧基，较低的烷氧羰基团或基团-COOSiR.sub.9 - R.sub.10 R.sub.11；而R.sub.5，可以相同也可以不同，表示至少一个线性或支链的C.sub.1 -C.sub.20烷基基团，甲酰基，线性或支链的C.sub.2 -C.sub.20酰基团，线性或支链的C.sub.3 -C.sub.20烯酰基团，基团--SiR.sub.9 R.sub.10 R.sub.11，基团--P(O)(OR.sub.6).sub.2或基团R.sub.6 OSO.sub.2 --，另一基团R.sub.4或R.sub.5可以是氢原子，R.sub.4和R.sub.5不同时为乙酰基，或者R.sub.4和R.sub.5，连同它们连接的氧原子，形成一个环，该环可以含有一个羰基团，一个硫代羰基团，一个基团>P(O)OR.sub.6或>CR.sub.7 R.sub.8；R.sub.6表示氢原子或较低的烷基基团，R.sub.7表示氢原子或较低的烷基基团，R.sub.8表示较低的烷氧基团或单烷基或二烷基氨基团，R.sub.9，R.sub.10和R.sub.11，可以相同也可以不同，表示线性或支链的较低烷基基团，以及碱金属、碱土金属、氨或胺的化妆上可接受的盐。

  公开号：

  US04822375A1
• 作为产物：
  描述：

  5,6-dimethoxy-3-methyl-indole-2-carboxylic acid 在 aluminum tri-bromide 、 苯 作用下， 生成 5,6-Dihydroxy-skatol
  参考文献：
  名称：

  Beer et al., Journal of the Chemical Society, 1949, p. 2061,2064

  摘要：

  DOI：

文献信息

• THIOL DYES
  申请人：Eliu Victor Paul

  公开号：US20090113639A1

  公开（公告）日：2009-05-07

  Disclosed are thiol dyes of formula (1), wherein R 1 is hydrogen; C 1 -C 12 alkyl; or phenyl-C 1 -C 4 alkyl; X is C 1 -C 12 alkylene; C 2 -C 12 alkenylene; C 5 -C 10 cycloalkylene; C 5 -C 10 arylene; or C 5 -C 10 arylene-C 1 -C 10 alkylene; Y is the residue of an organic dye which corresponds to the formula (1a), wherein R 2 is hydrogen; or C 1 -C 5 alkyl; R 3 is a radical of formula (1a 1 ): (1a 2 ); or (1a 3 ); or R 2 and R 3 together with the linking carbon atom 1 C form a 6 to 10 membered carbocyclic ring which may optionally be a condensated aromatic system and may contain one or more than one hetero atom; and R 4 , R 5 and R 6 independently form each other are hydrogen, or C 1 -C 5 alkyl; Z is H; or a thio ester group of formula (1b), wherein A is O; S; or N—R9; B is —OR7; —NR7R8, or —SR7; and A is O; S; or N—R 9 ; B is —OR 7 ; —NR 7 R 8 , or —SR 7 ; and R 7 , R 8 and R 9 , independently from each other are hydrogen; C 1 -C 12 alkyl C 6 -C 12 aryl; or C 6 -C 12 aryl-C 1 -C 12 alkyl. The compounds are useful for the dyeing of organic materials, such as keratin fibers, preferably human hair.

  揭示了式（1）的硫醇染料，其中R1为氢；C1-C12烷基；或苯基-C1-C4烷基；X为C1-C12亚烷基；C2-C12烯亚烷基；C5-C10环烷基；C5-C10芳基；或C5-C10芳基-C1-C10亚烷基；Y为与式（1a）对应的有机染料的残基，其中R2为氢；或C1-C5烷基；R3为式（1a1）的基团：（1a2）；或（1a3）；或R2和R3与连接碳原子1C形成6至10成员的碳环，该碳环可以选择性地是一个缩合芳香系统，并且可以含有一个或多个杂原子；以及R4，R5和R6独立地形成彼此为氢，或C1-C5烷基；Z为H；或式（1b）的硫酯基团，其中A为O；S；或N—R9；B为—OR7；—NR7R8，或—SR7；而A为O；S；或N—R9；B为—OR7；—NR7R8，或—SR7；且R7，R8和R9，彼此独立地为氢；C1-C12烷基；C6-C12芳基；或C6-C12芳基-C1-C12烷基。这些化合物适用于有机材料的染色，例如角蛋白纤维，最好是人类头发。
• Sun protection compositions comprising semi-crystalline polymers and hollow latex particles
  申请人：Candau Didier

  公开号：US20090041691A1

  公开（公告）日：2009-02-12

  Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30° C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.

  具有增强SPF的适用于化妆品/皮肤科的防紫外线保护组合物至少包含一种有机紫外线过滤剂和/或至少一种无机过滤剂，此类组合物还至少包含以下成分（A）和（B）： A）半结晶聚合物，室温下为固体，熔点大于或等于30°C，包含a）聚合骨架和b）至少一种可结晶有机侧链和/或作为该聚合物骨架一部分的可结晶有机块，该聚合物具有大于或等于1,000的数均分子质量Mn，以及 B）中空乳胶颗粒，粒径范围为150至380纳米，配制成适用于局部使用的、生理上可接受的介质。
• COSMETIC TREATMENT METHOD USING A COMPOUND THAT CAN BE CONDENSED IN SITU AND A UV-RADIATION-FILTERING AGENT
  申请人：Samain Henri

  公开号：US20120328542A1

  公开（公告）日：2012-12-27

  The present invention relates to a method for the cosmetic treatment of the skin, comprising the application, to the skin: of a compound or group of compounds A capable of condensing in situ and exhibiting at least one reactive functional group F A which is free after condensation; and of a screening agent C which screens out UV radiation, comprising a reactive functional group F C capable of forming a covalent bond or a physical (ionic, hydrogen) bond by reaction with the functional group F A .

  本发明涉及一种用于皮肤美容治疗的方法，包括将以下物质应用于皮肤： 一种或一组化合物A，能够在原位缩合并具有至少一个反应性功能基团F A ，在缩合后是自由的；以及 一种用于屏蔽紫外线辐射的筛选剂C，包括一个具有反应性功能基团F C 的物质，能够通过与功能基团F A 的反应形成共价键或物理（离子、氢）键。
• COMPOSITION COMPRISING A DIBENZOYLMETHANE SCREENING AGENT AND A MEROCYANINE DICYANO OR CYANOACETATE DERIVATIVE; METHOD FOR THE PHOTOSTABILIZATION OF THE DIBENZOYLMETHANE SCREENING AGENT
  申请人：L'OREAL

  公开号：US20150284330A1

  公开（公告）日：2015-10-08

  The present invention relates to a cosmetic composition comprising the combination i) of at least one screening agent of the dibenzoylmethane derivative type and ii) of at least one specific merocyanine dicyano or cyanoacetate derivative. It also relates to a method for the photostabilization, with regard to radiation, of at least one screening agent of the dibenzoylmethane derivative type by an effective amount of at least one specific merocyanine dicyano or cyanoacetate derivative.

  本发明涉及一种化妆品组合物，包括i)至少一种二苯甲酮衍生物型筛选剂的组合和ii)至少一种特定的梅洛氰二氰或氰乙酸酯衍生物。它还涉及一种方法，通过有效量的至少一种特定的梅洛氰二氰或氰乙酸酯衍生物，对至少一种二苯甲酮衍生物型筛选剂进行光稳定化处理，以抵御辐射。
• [EN] STYRYL SULFIDE DYES<br/>[FR] COLORANTS DE SULFURE DE STYRYLE
  申请人：BASF SE

  公开号：WO2015028543A1

  公开（公告）日：2015-03-05

  Disclosed are styryl dyes of formula (1) wherein R1, R2, R3, R'1, R'2 and R'3 independently of each other are hydrogen; -NH(CO)-C1-C5alkyl; -N(C1-C5alkyl)(C1-C5alkyl-CN); C1-C6alkoxy; a heterocyclic radical; or R1 and R2 or R'1 and R'2 together form a 5- to 10-membered, monocyclic, carbocyclic or heterocyclic ring; wherein at least one of R1, R2, R3, R'1, R'2 and R'3 is different from hydrogen; Q and Q' independently from each other are the direct bond; *-C(O)-*; *-C(O)O-*; *-OCO-*; *-N(R4)-*; (AA); *-C(O)N(R6)-*; or *-(R6)NC(O)-*; and R4, R5 and R6 independently from each other are hydrogen; C1-C14alkyl; C2-C14alkenyl; C6- C12aryl; C6-C12aryl-C1-C10alkyl; or C1-C10alkyl(C5-C12aryl); X and X' are *-(CH2)m-*; Y1 and Y2 independently from each other are C1-C10alkylene; C5-C10cycloalkylene; C5-C12arylene; or C5-C12arylene-(C1-C10alkylene); An- is an anion; m is a number from 1 to 8; n is 0, or 1; and p is 0, or 1.

  揭示了式（1）的苯基染料，其中R1、R2、R3、R'1、R'2和R'3彼此独立地为氢；-NH（CO）-C1-C5烷基；-N（C1-C5烷基）（C1-C5烷基-CN）；C1-C6烷氧基；一个杂环基；或者R1和R2或R'1和R'2一起形成一个5到10个成员的、单环的、碳环的或杂环的环；其中R1、R2、R3、R'1、R'2和R'3中至少有一个不同于氢；Q和Q'彼此独立地为直接键；*-C（O）-*；*-C（O）O-*；*-OCO-*；*-N（R4）-*；（AA）；*-C（O）N（R6）-*；或者*-(R6)NC（O）-*；而R4、R5和R6彼此独立地为氢；C1-C14烷基；C2-C14烯基；C6-C12芳基；C6-C12芳基-C1-C10烷基；或者C1-C10烷基（C5-C12芳基）；X和X'为*-(CH2)m-*；Y1和Y2彼此独立地为C1-C10烷基；C5-C10环烷基；C5-C12芳基；或者C5-C12芳基-(C1-C10烷基)；An-为阴离子；m为1至8的数字；n为0或1；p为0或1。