3-Hydroxy-9-phenoxynonanoic acid | 155638-21-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-Hydroxy-9-phenoxynonanoic acid
• CAS: 155638-21-4
• 化学式: C₁₅H₂₂O₄
• 分子量: 266.33
• InChiKey: AAPYQLZXVZEIAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Hydroxy-5-phenoxypentanoic acid 、 3-Hydroxy-7-phenoxyheptanoic acid 、 3-Hydroxy-9-phenoxynonanoic acid 在 YN2 作用下， 以can be produced by the strain YN2 with a substrate 11-phenoxyundecanoic acid的产率得到11-苯氧基十一烷酸
  参考文献：
  名称：

  Polyhydroxyalkanoate, method for production thereof and microorganisms for use in the same

  摘要：

  一种聚羟基烷酸酯，其单体单元组成式由通式（1）表示：AmB（1-m）（1），其中A由通式（2）表示，B是由通式（3）或（4）表示的单体单元组成的群体中至少选择一种，m的值大于或等于0.01且小于1:1，其中n的值为0到10，k的值为3或5，R是至少选择由通式（5）到（7）表示的群体中的一个群体：2在式（5）中，R1是从氢原子（H），卤素原子，—CN，—NO2，—CF3，—C2F5和—C3F7组成的群体中选择的一个群体；q是从1到8选择的整数；在式（6）中，R2是从氢原子（H），卤素原子，—CN，—NO2，—CF3，—C2F5和—C3F7组成的群体中选择的一个群体；r是从1到8选择的整数；在式（7）中，R3是从氢原子（H），卤素原子，—CN，—NO2，—CF3，—C2F5和—C3F7组成的群体中选择的一个群体；s是从1到8选择的整数。同时提供了高效生产方法。

  公开号：

  US20030208029A1

文献信息

• Polyhydroxyalkanoates and method of producing them by utilizing mircroorganisms
  申请人：——

  公开号：US20010029039A1

  公开（公告）日：2001-10-11

  A microbial polyhydroxyalkanoate which comprises one or more of monomer units represented by Formula (1), 1 where R is at least one selected from the group represented by any one of Formulas (2), (3) and (4); 2 in Formula (2), R1 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and q is an integer of 1 to 8; in Formula (3), R2 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and r is an integer of 1 to 8; in Formula (4), R3 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and s is an integer of 1 to 8. The production method is also disclosed.

  一种微生物聚羟基烷酸酯，包括由式（1）表示的单体单元中的一个或多个，其中R至少选自式（2）、（3）和（4）所表示的任一组中的一种；在式（2）中，R1选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的一组中，q是1到8的整数；在式（3）中，R2选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的一组中，r是1到8的整数；在式（4）中，R3选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的一组中，s是1到8的整数。同时公开了生产方法。
• Process for producing polyhydroxyalkanoates by utilizing microorganisms
  申请人：——

  公开号：US20030180899A1

  公开（公告）日：2003-09-25

  A microbial polyhydroxyalkanoate which comprises one or more of monomer units represented by Formula (1), 1 where R is at least one selected from the group represented by any one of Formulas (2), (3) and (4); 2 in Formula (2), R1 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and q is an integer of 1 to 8; in Formula (3), R2 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and r is an integer of 1 to 8; in Formula (4), R3 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and s is an integer of 1 to 8. The production method is also disclosed.

  一种微生物聚羟基脂肪酸酯，包括由公式（1）表示的单体单元中的一个或多个，其中R至少选自任一公式（2）、（3）和（4）所表示的组中之一；在公式（2）中，R1从氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的组中选择，q为1至8的整数；在公式（3）中，R2从氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的组中选择，r为1至8的整数；在公式（4）中，R3从氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的组中选择，s为1至8的整数。还公开了生产方法。
• Particulate construct comprising polyhydroxyalkanoate and method for producing it
  申请人：——

  公开号：US20030194443A1

  公开（公告）日：2003-10-16

  The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.

  本发明提供了一种微粒构造物，例如包含药物的微胶囊，用作缓释制剂，不会出现实际上不可接受的初始爆发释放，但在一定时间内显示实际上可接受的零级释放，并提供了这种微粒构造物的制备方法，以及能够稳定地将药物纳入微粒构造物中，例如微胶囊的高药物含量的缓释制剂，以及这种制备方法。本发明还提供了一种利用高功能聚合物化合物并将油相和/或水相纳入固相的微粒构造物，以及其制备方法。此外，本发明还提供了一种具有单一聚合物膜的空心结构的微粒构造物，能够在细小的颗粒中包含许多气泡，并提供了一种能够高度重复制备这种构造物的制备方法。根据本发明，可使用具有特定结构的聚羟基烷酸酯和药物制备微粒构造物，该构造物中包含油相和/或水相或气态相。
• Electrostatic charge image developing toner, producing method therefor, image forming method and image forming apparatus utilizing the toner, construct and method for making the construct
  申请人：Canon Kabushiki Kaisha

  公开号：US20040259026A1

  公开（公告）日：2004-12-23

  A construct that comprises a base material and a polyhydroxyalkanoate, wherein at least a part of the base material is coated with the polyhydroxyalkanoate, and the polyhydroxyalkanoate comprises a 3-hydroxyalkanoic acid unit other than 3-hydroxypropionic acid unit, 3-hydroxy-n-butyric acid unit, and 3-hydroxy-n-valeric acid unit. In addition, an electrostatic charge image developing toner allows to design the toner characteristics such as chargeability, flowability, stability in time and environmental stability uniform among the toners of different colors. The toner has a small particle size enough for enabling uniform dispersion and being excellent in color saturation and transparency. The toner also shows higher contribution to the environmental security. The toner includes a coloring agent of which at least a part of the surface is covered with polyhydroxyalkanoate (PHA). The toner is produced by dispersing the coloring agent in aqueous medium, then fixing PHA synthesizing enzyme to the coloring agent dispersed in the aqueous medium, then adding 3-hydroxyacyl CoA, and executing a PHA synthesizing reaction to cover at least a part of the surface of the coloring agent with PHA. The toner thus obtained is used for an image forming method.

  一种构造物，包括基材料和聚羟基脂肪酸酯，其中至少一部分基材料被聚羟基脂肪酸酯涂覆，而聚羟基脂肪酸酯包括除了3-羟基丙酸单元、3-羟基-n-丁酸单元和3-羟基-n-戊酸单元之外的3-羟基脂肪酸单元。 此外，静电荷图像开发调色剂可以使调色剂的特性如电荷性、流动性、时间稳定性和环境稳定性在不同颜色的调色剂之间保持一致。调色剂具有足够小的粒径，足以实现均匀分散，并具有优异的色彩饱和度和透明度。调色剂还显示出更高的环境安全贡献。调色剂包括至少部分表面覆盖聚羟基脂肪酸酯（PHA）的着色剂。调色剂通过将着色剂分散在水性介质中，然后将PHA合成酶固定在分散在水性介质中的着色剂上，然后添加3-羟基酰基辅酶A，并执行PHA合成反应，以覆盖至少着色剂表面的一部分与PHA。因此获得的调色剂用于图像形成方法。
• Polyhydroxyalkanoate containing 3-hydroxythienylalkanoic acid as monomer unit and method for producing the same
  申请人：——

  公开号：US20020065389A1

  公开（公告）日：2002-05-30

  Microorganisms capable of synthesizing novel polyhydroxyalkanoate having 3-hydroxythienylalkanoic acid as monomer unit, using thienylalkanoic acid as a stock are cultured on a culture medium containing thienylalkanoic acid, and the polyhydroxyalkanoate produced in the cultured cell is extracted and

  具有合成新型3-羟基噻吩烷基酸单体聚羟基脂肪酸能力的微生物，使用噻吩烷基酸作为原料，在含有噻吩烷基酸的培养基上培养，提取培养细胞中产生的聚羟基脂肪酸。